The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Belova L.A.

Ul'ianovskiĭ gosudarstvennyĭ universitet

Mashin V.V.

Abramova V.V.

Proshin A.N.

Ulyanovsk State University, Ulyanovsk

Ovsjannikova A.N.

Ulyanovsk State University, Ulyanovsk, Russia

Efficacy of cortexin in acute and recovery periodes of hemispheric ischemic stroke

Authors:

Belova L.A., Mashin V.V., Abramova V.V., Proshin A.N., Ovsjannikova A.N.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(10): 38‑42

DOI: 10.17116/jnevro201611610138-42

Read: 2932 times

Download PDF (RU)
Contact the author
Table of contents

EFFICACY OF CORTEXIN IN ACUTE AND RECOVERY PERIODES OF HEMISPHERIC ISCHEMIC STROKE
EFFICACY OF CORTEXIN IN ACUTE AND RECOVERY PERIODES OF HEMISPHERIC ISCHEMIC STROKE

To cite this article:

Belova LA, Mashin VV, Abramova VV, Proshin AN, Ovsjannikova AN. Efficacy of cortexin in acute and recovery periodes of hemispheric ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(10):38‑42. (In Russ.)
https://doi.org/10.17116/jnevro201611610138-42

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Adju­vant pharmacological modu­lation with Cyto­flavin in reha­bilitation at stages 2—3 in patients with acute cere­bral insu­fficiency and post-intensive care syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):78-85
Pote­ntial of animal-derived neuropeptides in complex therapy of diabetic neuropathy in patients with type 2 diabetes mellitus. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4):83-87
The known and new ideas about the mechanism of action and the spectrum of effe­cts of Mexi­dol. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):22-33
Therapeutic pote­ntial of quercetin and its deri­vatives against COVID-19. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):44-50
The possibility of using neurotropic therapy in patients with persistent postural-perceptual dizziness. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):89-94
Proinflammatory cyto­kines — as a marker of the effe­ctiveness of neuroprotection in children with peri­natal nervous system damage. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):62-66
Anesthetic mana­gement of endo­vascular procedures in patients with ischemic stroke. Russian Journal of Anesthesiology and Reanimatology. 2025;(2):20-25
Comparison of fluoroscopy and intracardiac echo­cardiography for control of endo­vascular closure of patent fora­men ovale. Russian Cardiology Bulletin. 2025;(1):64-69
Mathematical mode­ling of outcomes in patients with clinical combination of ischemic stroke and COVID-19 complicated by multiple organ failure. Russian Journal of Anesthesiology and Reanimatology. 2025;(3):42-49
Socio-economic damage caused by elevated low-density lipo­protein cholesterol levels. Medi­cal Technologies. Asse­ssment and Choice. 2025;(2):88-98
Abstract:

Objective. To study the effectiveness and sustained effects of early appointment of a repeated course of low-dose drug cortexin neuroprotection in patients in acute and recovery period of hemispheric ischemic stroke. Material and methods. The study included 90 patients with hemispheric ischemic stroke. Patients of the first group received 20 mg cortexin (10+10) intramuscularly on basic therapy, the patients of the second group (n=30) was obtained cortexin 20 mg (10+10) in the two courses each for 10 days with an interval between them in 10 days, patients of the third group — only basic therapy. For objectification severity used NIH stroke scale, modified Rankin scale, the Barthel index, the Rivermead mobility index, MMSE. Results and conclusion. Appointment in acute hemispheric ischemic stroke drug cortexin repeated course leads to more complete regression of neurological deficit, compared to the comparison group and the group of patients who received one course of medication cortexin, for all acute and early recovery period of ischemic stroke from 11—13 days of illness.

Keywords:

cortexin
ischemic stroke
treatment of stroke
neuroprotection

Authors:

Belova L.A.

Ul'ianovskiĭ gosudarstvennyĭ universitet

Mashin V.V.

Abramova V.V.

Proshin A.N.

Ulyanovsk State University, Ulyanovsk

Ovsjannikova A.N.

Ulyanovsk State University, Ulyanovsk, Russia

Close metadata

References:

  1. Skvorcova VI. Stanovlenie sistemy okazanija medicinskoj pomoshhi bol'nym s cerebral'nym insul'tom v Rossijskoj Federacii. Materialy Vserossijskoj nauchno-prakticheskoj konferencii «Sovershenstvovanie okazanija medicinskoj pomoshhi bol'nym s sosudistymi zabolevanijami». M.: Real Tajm; 2011. (In Russ.).
  2. Mashin VV, Pinkova EA, Vinokurov LN, Gavrilov VN, Mashina TV, Belova LA. Faktory riska pri gipertonicheskoj jencefalopatii i vozmozhnye puti ih farmakologicheskoj korrekcii. Medicinskij al'manah. 2011;1(14):195-197. (In Russ.).
  3. Belova LA, Mashin VV. Venoznaja discirkuljacija pri hronicheskih formah cerebrovaskuljarnoj patologii. Ul'janovsk: UlGU; 2015. (In Russ.).
  4. Siegler JE, Martin-Schild S. Early Neurological Deterioration (END) after stroke: the END depends on the definition. International Journal of Stroke Organization. 2011;6:211-212. doi: 10.1111/j.1747-4949.2011.00596.x
  5. Mashin VV, Belova LA, Saprygina LV, Kravchenko MA, Varakin JuJa, Gnedovskaja EV, Suslina ZA. Faktory riska razvitija cerebrovaskuljarnyh zabolevanij po dannym skrininga populjacii srednego vozrasta Ul'janovska. Annaly klinicheskoj i jeksperimental'noj nevrologii. 2014;8(1):4-9. (In Russ.).
  6. Lindsay P, Furie KL, Davis SM, Dunnan GA, Norrvig D. World stroke organization global stroke services guidelines and action plan. Int J Stroke. 2014;9(100):4-13. doi: 10.1111/ijs.12371
  7. Belova L, Mashin V, Belova N. Hypertensive Encephalopathy: The Role Of Arteriovenous Interrelations In The Formation Of Its Clinical-Pathogenetic Subtypes. Experimental & Clinical Cardiology. 2014;20(7):892-898.
  8. Belova LA, Mashin VV, Saprygina LV, Kravchenko MA, Gnedovskaja EV, Oshhepkova EV, Varakin JuJa, Suslina ZA. Struktura cerebrovaskuljarnoj patologii v otkrytoj populjacii rabotosposobnogo naselenija Ul'janovska. Annaly klinicheskoj i jeksperimental'noj nevrologii. 2014;4(8):4-8. (In Russ.).
  9. Thrift AG, Cadilhac DA, Thayabaranathan T, Howard G, Howard VJ, Rothwell PM, Donnan GA. Global stroke statistics. J Stroke. 2014;9(1):6-18. doi: 10.1111/ijs.12245
  10. Nevrologija. Nacional'noe rukovodstvo. Pod red. Guseva EI, Konovalova AN, Skvorcovoj VI, Geht AB.. M.: GJeOTAR-Media; 2009. (In Russ.).
  11. Kotova EJu, Mashin VV. Osnovnye jepidemiologicheskie harakteristiki insul'ta i dopolnitel'nye metody obsledovanija bol'nyh insul'tom v Ul'janovske (po dannym Registra insul'ta). Bjulleten' sibirskoj mediciny. 2008;5(3):179. (In Russ.).
  12. Korteksin — pjatiletnij opyt otechestvennoj nevrologii. Pod red. Skoromca AA, D'jakonova MM. SPb.: Nauka; 2005. (In Russ.).
  13. Mashin VV, Belova LA, Chaplanova OI, Husnullina AF, Manasjan AM. Okrytoe klinicheskoe issledovanie preparata korteksin pri discirkuljatornoj jencefalopatii. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2014;114(9):49-52. (In Russ.). doi: 10.1007/s11055-016-0247-4 
  14. Nevrologicheskij deficit, sindrom poliorgannoj nedostatochnosti u bol'nyh s ishemicheskim insul'tom v ostrom i rannem vosstanovitel'nom periodah, vozmozhnosti preparata korteksina. Sbornik nauchnyh statej «Cerebrovaskuljarnaja patologija — novye vozmozhnosti nizkodozirovannoj nejroprotekcii». Pod red. Skoromca AA, Stahovskoj LV. SPb.: Izdatel'stvo Nauka; 2014. (In Russ.).
  15. Brott T, Adams HP Jr, Olinger CP, Marler JR, Barsan WG, Biller J, Spilker J, Holleran R, Eberle R, Hertzberg V. Measurements of acute cerebral infarktion — a clinical examination scale. Stroke. 1989;20:864-870. doi:10.1161/01.str.20.7.864
  16. Mnogokratnaja kursovaja nejroprotekcija v terapii postinsul'tnyh kognitivnyh narushenij. Cerebral'naja patologija — novye vozmozhnosti nizkodozirovannoj nejroprotekcii. Sbornik nauchnyh statej. Pod red. Skoromca AA, Stahovskoj LV. SPb.: Nauka; 2014. (In Russ.).
  17. Ashmarin IP, Obuhova MF. Reguljatornye peptidy, funkcional'no-nepreryvnaja sovokupnost'. Biohimija. 1986;51(4):531-545. (In Russ.).
  18. Koroleva SV, Nikolaeva AA, Ashmarin IP. Tipy bioinformacionnyh programm vnutri kontinuuma reguljatornyh peptidov i nepeptidnyh mediatorov. Osobennosti vzaimodejstvija dofaminovoj i serotoninovoj sistem. Nejrohimija. 2012;2:150-161. (In Russ.).
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.