Clinical characteristics of pain syndrome in patients with multiple myeloma

The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Search result: 0

Stamo А.P.

Nizhnegorodskay State Medical Academy, Nizhny Novgorod, Russia

Grigor'eva V.N.

Nizhegorodskaia gosudarstvennaia meditsinskaia akademiia, Nizhniĭ Novgorod

Clinical characteristics of pain syndrome in patients with multiple myeloma

Authors:

Stamo А.P., Grigor'eva V.N.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(10): 11‑15

DOI: 10.17116/jnevro201611610111-15

Read: 17315 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Stamo АP, Grigor'eva VN. Clinical characteristics of pain syndrome in patients with multiple myeloma. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(10):11‑15. (In Russ.)
https://doi.org/10.17116/jnevro201611610111-15

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

β-Adrenoreceptors types 1 and 2 in the diagnosis of pain syndrome in patientswith various forms of adenomyosis. Russian Journal of Human Reproduction. 2025;(1):35-43

Pharmacological pain management in pediatric intensive care. Russian Journal of Pain. 2025;(1):56-61

Deep endometriosis — a comparative study of pain syndrome and the prevalence of clinical symptoms according to the #ENZIAN classification. Russian Journal of Human Reproduction. 2025;(4):96-101

Rehabilitation of patients with vertebrogenic muscular-tonic and radicular syndromes. Problems of Balneology, Physiotherapy and Exercise Therapy. 2025;(6):13-18

Abstract:

Objective. To study pain syndrome characteristics in the trunk and extremities of patients with multiple myeloma (MM). Material and methods. The study involved 120 patients with MM, aged from 34 to 83 years. The duration of disease was 2—37 months. Results and conclusion. The pain syndrome of trunk and extremity localization was revealed in 94% patients, its intensity according to the VAS was 65.5±25.4 mm. At all stages of disease, moderate to severe pain, predominantly related to polyneuropathy (PNP), radiculopathy and osteodestruction, was more frequent. Radicular pain syndrome was revealed in 46% of all MM patients, and in the majority of cases (92%), there were bone destruction lesions. The character of pain in MM should be specified to optimize further management of the patient.

Keywords:

multiple myeloma

polyneuropathy

radiculopathy

pain syndrome

Authors:

Stamo А.P.

Nizhnegorodskay State Medical Academy, Nizhny Novgorod, Russia

Grigor'eva V.N.

Nizhegorodskaia gosudarstvennaia meditsinskaia akademiia, Nizhniĭ Novgorod

Close metadata

References:

Votjakova OM, Demina EA. Mnozhestvennaja mieloma. Klinicheskaja onkogematologija. Pod red. Volkovoj MA. M.: Medicina; 2001. (In Russ.).
Gertz MA, Greipp PR. Multiple Myeloma and Related Plasma Cell Disorders. Berlin: Springer-Verlag; 2004. doi: 10.1007/978-3-662-08885-2
Pollard JD, Young GAR. Neurology and the bone marrow. Journal of Neurology, Neurosurgery & Psychiatry. 1997;63(6):706-717. doi: 10.1136/jnnp.63.6.706
Oshima K, Kanda Y, Nannya Y, Kaneko M, Hamaki T, Suguro M et al. Clinical and pathologic findings in 52 consecutively autopsied cases with multiple myeloma. American Journal of Hematology. 2001;67(1):1-5. doi: 10.1002/ajh.1067
Talerman A. Clinico-pathological study of multiple myeloma in Jamaica. British Journal of Cancer. 1969;23(2):285-293. doi:10.1038/bjc.1969.38
Niscola P, Scaramucci L, Romani C, Giovannini M, Tendas A, Brunetti G et al. Pain management in multiple myeloma. Expert Review of Anticancer Therapy. 2010;10(3):415-425. doi: 10.1586/era.10.5
Joshi A, Jiang D, Singh P, Moffat D. Skull base presentation of multiple myeloma. Ear Nose Throat J. 2011;90(1):6-9.
Vermeiren P, Vantilborgh A, Offner F. Myeloma of the central nervous system: report of a single center case series. Acta Clin Belg. 2011;66(3):205-208.
Kapadia SB. Multiple myeloma: a clinicopathological study of 62 consecutively autopsied cases. Medicine. 1980;59(5):380-392. doi: 10.1097/00005792-198009000-00005
Desforges JF, Byrne TN. Spinal Cord Compression from Epidural Metastases. N Engl J Med. 1992;327(9):614-619. doi: 10.1056/nejm199208273270907
Hu KC, Lin J, Chuang YC et al. Multiple myeloma associated with extramedullary plasmacytoma causing nerve root compression: a case report. J Formos Med Assoc. 2001;100(4):277-280.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A et al. Review of 1027 Patients With Newly Diagnosed Multiple Myeloma. Mayo Clinic Proceedings. 2003;78(1):21-33. doi: 10.4065/78.1.21
Malpas JS, Bergsagel DE, Kyle RA, Anderson KC. Myeloma: Biology and Management. Philadelphia: Saunders; 2004.
Bosch EP, Smith BE. Peripheral neuropathies associated with monoclonal proteins. Med Clin North Am. 1993;77(1):125-139. doi: 10.1016/s0025-7125(16)30276-0
Rukovodstvo po gematologii. Pod red. Vorob'eva AI. Tver': OOO «Izdatel'stvo «Triada»; 2003. (In Russ.).
Sidorovich GI. Faktory prognoza i dopolnenija k klassifikacii mnozhestvennoj mielomy: Dis. ... d-ra med. nauk. M. 2003. (In Russ.).
Hájek R, Krejcí M, Pour L, Adam Z. Multiple myeloma. Klin Onkol. 2011;24:11-13.
Byval'cev VA, Belyh EG, Sorokovikov VA, Arsent'eva NI. Ispol'zovanie shkal i anket v vertebrologii. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2011;9:51-56. (In Russ.).
Howell DA, Smith AG, Jack A, Patmore R, Macleod U, Mironska E et al. Time-to-diagnosis and symptoms of myeloma, lymphomas and leukaemias: a report from the Haematological Malignancy Research Network. BMC Hematology. 2013;13(1):9. doi: 10.1186/2052-1839-13-9
Madu A, Ocheni S, Nwagha T, Ibegbulam O, Anike U. Multiple myeloma in Nigeria: An insight to the clinical, laboratory features, and outcomes. Niger J Clin Pract. 2014;17(2):212-217. doi: 10.4103/1119-3077.127561
Zhang J, Sun W, Huang Z, Chen S, Zhong Y, Hu Y et al. Light chain multiple myeloma, clinic features, responses to therapy and survival in a long-term study. World Journal of Surgical Oncology. 2014;12(1):234. doi: 10.1186/1477-7819-12-234
Sobol U, Stiff P. Neurologic aspects of plasma cell disorders. In: Handbook of Clinical Neurology. Elsevier BV; 2014;1083-1099. doi:10.1016/b978-0-7020-4087-0.00073-5
Dispenzieri A, Kyle RA. Neurological aspects of multiple myeloma and related disorders. Best Practice & Research Clinical Haematology. 2005;18(4):673-688. doi: 10.1016/j.beha.2005.01.024
Thawani SP, Tanji K, De Sousa EA, Weimer LH, Brannagan TH. Bortezomib-Associated Demyelinating Neuropathy — Clinical and Pathologic Features. Journal of Clinical Neuromuscular Disease. 2015;16(4):202-209. doi: 10.1097/cnd.0000000000000077
Koeppen S. Treatment of Multiple Myeloma: Thalidomide-, Bortezomib- and Lenalidomide-Induced Peripheral Neuropathy. Oncol Res Treat. 2014;37(9):506-513. doi: 10.1159/000365534
Shi Q, Wang XS, Li G, Shah ND, Orlowski RZ, Williams LA, et al. Racial/ethnic disparities in inflammatory gene single-nucleotide polymorphisms as predictors of a high risk for symptom burden in patients with multiple myeloma 1 year after diagnosis. Cancer. 2014;121(7):1138-1146. doi: 10.1002/cncr.29154
Jakovlev AA, Jakovleva MV. Klinicheskie osobennosti perifericheskoj nejropatii pri paraproinemicheskih gemoblastozah. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2014;114(10):5-8. (In Russ.).

Log in to the site using your account in one of the services

Registration

Last Name

Name

Middle Name

E-mail

Phone

Address

Country

Zip

City

Region

Street

Home

Apartmen

Legal entity name

ИНН

КПП

Password

Password

Repeat password

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.