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Saroaynts L.V.

Astrakhan State Medical University;
Tatishchev Astrakhan State University

Bayrambekova M.R.

Astrakhan State Medical University

Naumov V.Z.

Astrakhan State Medical University

Naumov A.V.

Astrakhan State Medical University

Clinical and diagnostic investigation of neopterin level in complication of leprosy

Authors:

Saroaynts L.V., Bayrambekova M.R., Naumov V.Z., Naumov A.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2024;23(4): 392‑397

DOI: 10.17116/klinderma202423041392

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CLINICAL AND DIAGNOSTIC INVESTIGATION OF NEOPTERIN LEVEL IN COMPLICATION OF LEPROSY
CLINICAL AND DIAGNOSTIC INVESTIGATION OF NEOPTERIN LEVEL IN COMPLICATION OF LEPROSY

To cite this article:

Saroaynts LV, Bayrambekova MR, Naumov VZ, Naumov AV. Clinical and diagnostic investigation of neopterin level in complication of leprosy. Russian Journal of Clinical Dermatology and Venereology. 2024;23(4):392‑397. (In Russ.)
https://doi.org/10.17116/klinderma202423041392

 
Подписка 2025-2 (Russian Journal of Clinical Dermatology and Venereology)
 
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Leprosy is a chronic infectious granulomatous disease caused by M. leprae, affecting the skin with the development of complications in the form of polyneuropathies.

OBJECTIVE

To investigate neopterin concentration in leprosy patients depending on the severity of specific polyneuritis course.

MATERIAL AND METHODS

A number of persons equal 58 were examined: 15 patients with leprosy with slow progression of leprous polyneuropathy (I group), 16 patients with sensory processing disorders (II group), 12 patients without signs of specific polyneuropathy (III group) and 15 somatically healthy volunteers (control).

RESULTS

The highest values were observed in patients of I group compared to all other groups (p<0.01) on admission to the hospital. The indices were statistically significantly higher in II group patients than in III group and control group (p<0.05). After anti-inflammatory therapy, neopterin level decreased by the 2nd month, dropping to normal values by the 6th month after treatment completion. Nevertheless, neopterin concentration and IgM to M. leprae level remained high in 4 patients of I group after 6 months. They developed a repeated exacerbation after 3 months.

CONCLUSION

The use of named indices in leprosy can improve the predictive accuracy of leprous polyneuropathy exacerbation development, promote effective treatment strategy and reduce the disabling consequences of leprosy.

Keywords:

leprosy
neopterin
polyneuropathy
Schwann cells
M.leprae

Authors:

Saroaynts L.V.

Astrakhan State Medical University;
Tatishchev Astrakhan State University

Bayrambekova M.R.

Astrakhan State Medical University

Naumov V.Z.

Astrakhan State Medical University

Naumov A.V.

Astrakhan State Medical University

Received:

29.12.2023

Accepted:

21.05.2024

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