The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Saroyants L.V.

Astrakhan State Medical University;
Astrakhan State University named after V.N. Tatishchev

Bayrambekova M.R.

Astrakhan State Medical University

Naumov V.Z.

Astrakhan State Medical University

Naumov A.V.

Astrakhan State Medical University

Clinical and diagnostic investigation of neopterin level in complication of leprosy

Authors:

Saroyants L.V., Bayrambekova M.R., Naumov V.Z., Naumov A.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2024;23(4): 392‑397

DOI: 10.17116/klinderma202423041392

Read: 707 times

Download PDF (RU)
Contact the author
Table of contents

CLINICAL AND DIAGNOSTIC INVESTIGATION OF NEOPTERIN LEVEL IN COMPLICATION OF LEPROSY
CLINICAL AND DIAGNOSTIC INVESTIGATION OF NEOPTERIN LEVEL IN COMPLICATION OF LEPROSY

To cite this article:

Saroyants LV, Bayrambekova MR, Naumov VZ, Naumov AV. Clinical and diagnostic investigation of neopterin level in complication of leprosy. Russian Journal of Clinical Dermatology and Venereology. 2024;23(4):392‑397. (In Russ.)
https://doi.org/10.17116/klinderma202423041392

 
Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Main dire­ctions in corneal nerve fibers research. Russian Annals of Ophthalmology. 2024;(6):118-124
Neurological complications resu­lting of nitrous oxide into­xication. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):41-46
Abstract:

Leprosy is a chronic infectious granulomatous disease caused by M. leprae, affecting the skin with the development of complications in the form of polyneuropathies.

OBJECTIVE

To investigate neopterin concentration in leprosy patients depending on the severity of specific polyneuritis course.

MATERIAL AND METHODS

A number of persons equal 58 were examined: 15 patients with leprosy with slow progression of leprous polyneuropathy (I group), 16 patients with sensory processing disorders (II group), 12 patients without signs of specific polyneuropathy (III group) and 15 somatically healthy volunteers (control).

RESULTS

The highest values were observed in patients of I group compared to all other groups (p<0.01) on admission to the hospital. The indices were statistically significantly higher in II group patients than in III group and control group (p<0.05). After anti-inflammatory therapy, neopterin level decreased by the 2nd month, dropping to normal values by the 6th month after treatment completion. Nevertheless, neopterin concentration and IgM to M. leprae level remained high in 4 patients of I group after 6 months. They developed a repeated exacerbation after 3 months.

CONCLUSION

The use of named indices in leprosy can improve the predictive accuracy of leprous polyneuropathy exacerbation development, promote effective treatment strategy and reduce the disabling consequences of leprosy.

Keywords:

leprosy
neopterin
polyneuropathy
Schwann cells
M.leprae

Authors:

Saroyants L.V.

Astrakhan State Medical University;
Astrakhan State University named after V.N. Tatishchev

Bayrambekova M.R.

Astrakhan State Medical University

Naumov V.Z.

Astrakhan State Medical University

Naumov A.V.

Astrakhan State Medical University

Received:

29.12.2023

Accepted:

21.05.2024

Close metadata

References:

  1. Scollard DM. The biology of nerve injury in leprosy. Leprosy Review. 2008; 79;3:242-253.  https://doi.org/10.47276/lr.79.3.242
  2. Leon KE, Jacob JT, Franco-Paredes C, Kozarsky PE, Wu HM, Fairley JK. Delayed diagnosis, leprosy reactions, and nerve injury among individuals with hansen’s disease seen at a united states clinic. Open Forum Infect Dis. 2016;3:ofw063. https://doi.org/10.1093/ofid/ofw063
  3. Sviridov EA, Telegina TA. Neopterin and its reduced forms: biological role and participation in cell immunity. Uspekhi biologicheskoj khimii. 2005;45: 355-390. (In Russ.).
  4. Plata-Nazar K, Jankowska A. Clinical Usefulness of Determining the Concentration of Neopterin. Pteridines. 2011;22:77-89.  https://doi.org/10.1515/pteridines.2011.22.1.77
  5. Estelberger W, Weiss G, Petek W, Paletta B, Wachter H, Reibnegger G. Determination of renal clearance of neopterin by a pharmacokinetic approach. FEBS Lett. 1993;329(1-2):13-16.  https://doi.org/10.1016/0014-5793(93)80182-t
  6. Jebari-Benslaiman S, Galicia-García U, Larrea-Sebal A, Olaetxea JR, Alloza I, Vandenbroeck K, Benito-Vicente A, Martín C. Pathophysiology of Atherosclerosis. Int J Mol Sci. 2022;23(6):3346. PMID: 35328769. https://doi.org/10.3390/ijms23063346
  7. Naumov AV, Prokofieva TV, Saroyants LV, Polunina OS. Clinical-diagnostic value of the study of neopterin in myocardial infarction on the background of chronic obstructive pulmonary disease. Kuban Scientific Medical Bulletin. 2018;25(2):121-126. (In Russ.). https://doi.org/10.25207/1608-6228-2018-25-2-121-126
  8. Endres D, Frye BC, Schlump A, Kuzior H, Feige B, Nickel K, Urbach H, Schiele MA, Domschke K, Berger B, Stich O, Venhoff N, Prüss H, Tebartz van Elst L. Sarcoidosis and obsessive-compulsive symptoms. J Neuroimmunol. 2022;373:577989. https://doi.org/10.1016/j.jneuroim.2022.577989
  9. Melichar B, Spisarová M, Bartoušková M, Krčmová LK, Javorská L, Študentová H. Neopterin as a biomarker of immune response in cancer patients. Ann Transl Med. 2017;5(13):280.  https://doi.org/10.21037/atm.2017.06.29
  10. Ozger HS, Dizbay M, Corbacioglu SK, Aysert P, Demirbas Z, Tunccan OG, Hizel K, Bozdayi G, Caglar K. The Prognostic Role of Neopterin in  COVID-19 Patients. J Med Virol. 2021;93:1520-1525. https://doi.org/10.1002/jmv.26472
  11. Williams ME, Stein DJ, Joska JA, Naudé PJW. Cerebrospinal fluid immune markers and HIV-associated neurocognitive impairments: A systematic review. J Neuroimmunol. 2021;15:358:577649. https://doi.org/10.1016/j.jneuroim.2021.577649
  12. Saghazadeh A, Rezaei N. Elevated neopterin in tuberculosis and co-infection with HIV and the effect of treatment: A systematic review, meta-analysis, and meta-regression. Int Immunopharmacol. 2022;111:109147. https://doi.org/10.1016/j.intimp.2022.109147
  13. Mendy J, Togyn T, Owolabi O, et al. C-reactive protein, Neopterin and Beta2 microglobulin levels pre and post TB treatment in THE Gambia. BMC Infect. Dis. 2016;115:1447-1449. https://doi.org/10.1186/s12879-016-1447-9
  14. Esmedlyaeva DS, Alekseeva NP, Pavlova MV, Dyakova MT, Kiryukhina LD, Perovasa TL. Serum Neopterin as an integral indicator of process activityin patients with infiltrative pulmonary tuberculosis. Meditsinskij alyans. 2016;2:20-25. (In Russ.).
  15. Faber WR, Iyer AM, Fajardo TT, Dekker T, Villahermosa LG, Abalos RM, Das PK. Serial measurement of serum cytokines, cytokine receptors and neopterin in leprosy patients with reversal reactions. Lepr Rev. 2004;75(3): 274-281. 
  16. Ridley DS, Jopling WH. Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis. 1966;34:255-273. 
  17. Shac EI, Sarojanc LV, Naumov VZ. Actual issues of treatment of neurotrophic complications in leprosy patients. Meditsinskij alfavit. 2022;21:23-26. (In Russ.). https://doi.org/10.33667/2078-5631-2022-21-23-26
  18. Luo Y, Kiriya M, Tanigawa K, Kawashima A, Nakamura Y, Ishii N and Suzuki K. Host-Related Laboratory Parameters for Leprosy Reactions. Front Med. 2021;8:694376. https://doi.org/10.3389/fmed.2021.694376
  19. Lastória JC, Morgado de Abreu MAM. Leprosy (part 1): review of the epidemiological, clinical and etiopathogenic aspects. An Bras Dermatol. 2014; 89(2):205-218.  https://doi.org/10.1590/abd1806-4841.20142450
  20. Agrawal A, Pandit L, Dalal M, Shetty JP. Neurological manifestations of Hansen’s disease and their management. Clin Neurol Neurosurg. 2005; 107(6):445-454.  https://doi.org/10.1016/j.clineuro.2005.03.007
  21. Richardus JH, Nicholls PG, Croft RP, Withington SG, Smith WC. Incidence of acute nerve function impairment and reactions in leprosy: a prospective cohort analysis after 5 years of follow-up. Int J Epidemiol. 2004;33: 337-343.  https://doi.org/10.1093/ije/dyg225
  22. Saunderson P. The epidemiology of reactions and nerve damage. Lepr Rev. 2000;71:S106-110. 
  23. Hamerlinck FFV, Klatser PR, Walsh DS, Bos JD, Walsh GP, Faber WR. Serum neopterin as a marker for reactional states in leprosy. FEMS Immunology & Medical Microbiology. 1999;24(4):405-409.  https://doi.org/10.1111/j.1574-695X.1999.tb01312.x
  24. Silva EA, Iyer A, Ura S, Lauris JR, Naafs B, Das PK, Vilani-Moreno F. Utility of measuring serum levels of anti-PGL-I antibody, neopterin and C-reactive protein in monitoring leprosy patients during multi-drug treatment and reactions. Trop Med Int Health. 2007;12(12):1450-1458. https://doi.org/10.1111/j.1365-3156.2007.01951.x
  25. Gieseg SP, Baxter-Parker G, Lindsay A. Neopterin, Inflammation, and Oxidative Stress: What Could We Be Missing? Antioxidants (Basel). 2018;26; 7(7):80.  https://doi.org/10.3390/antiox7070080
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.