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Guzanova E.V.

Privolzhsky Research Medical University

Zorkova A.V.

Privolzhsky Research Medical University

Sorokina T.A.

Privolzhsky Research Medical University

The fixed combination of diclofenac and orphenadrine for radicular lower back pain

Authors:

Guzanova E.V., Zorkova A.V., Sorokina T.A.

More about the authors

Journal: Russian Journal of Pain. 2024;22(3): 74‑80

DOI: 10.17116/pain20242203174

Read: 1048 times

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Table of contents

THE FIXED COMBINATION OF DICLOFENAC AND ORPHENADRINE FOR RADICULAR LOWER BACK PAIN
THE FIXED COMBINATION OF DICLOFENAC AND ORPHENADRINE FOR RADICULAR LOWER BACK PAIN

To cite this article:

Guzanova EV, Zorkova AV, Sorokina TA. The fixed combination of diclofenac and orphenadrine for radicular lower back pain. Russian Journal of Pain. 2024;22(3):74‑80. (In Russ.)
https://doi.org/10.17116/pain20242203174

Подписка 2025 Российский журнал боли (Russian Journal of Pain)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Effective pain relief is a key goal in the treatment of acute spinal pain. Using of a fixed combination of nonsteroidal anti-inflammatory drug and a centrally acting muscle relaxant (Diclofenac 75 mg and Orphenadrine 30 mg) can effectively relieve pain, which creates conditions for active rehabilitation measures aimed at restoring normal biomechanics of the spinal column and the formation of correct physiological movement patterns.

Keywords:

acute pain in the lower back
radiculopathy
sequestration resorption

Authors:

Guzanova E.V.

Privolzhsky Research Medical University

Zorkova A.V.

Privolzhsky Research Medical University

Sorokina T.A.

Privolzhsky Research Medical University

Received:

05.07.2024

Accepted:

14.07.2024

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References:

  1. Oertel J, Sharif S, Zygourakis C, Sippl C. Acute low back pain: Epidemiology, etiology, and prevention: WFNS spine committee recommendations. World Neurosurg X. 2024;22:100313. https://doi.org/10.1016/j.wnsx.2024.100313
  2. Ushkalova EA, Zyryanov SK, Zatolochina KE. The fixed combination of diclofenac and orphenadrine in the treatment of acute pain syndromes. Nevrologiya, nejropsikhiatriya, psikhosomatika. 2020;12(1):100-104. (In Russ.).
  3. Ministerstvo zdravookhraneniya Rossijskoj Federatsii. Klinicheskie rekomendatsii «Degenerativnye zabolevaniya pozvonochnika», 2021 g. (In Russ.). https://cr.minzdrav.gov.ru/schema/727_1
  4. Chu EC, Sabourdy E. Non-surgical Restoration of L3/L4 Disc Herniation. Cureus. 2023;15(6):e40941. https://doi.org/10.7759/cureus.40941
  5. Zou T, Liu X-Y, Wang P-C, Chen H, Wu P-G, Feng X-M, Sun H-H. Incidence of Spontaneous Resorption of Lumbar Disc Herniation: A Meta-analysis. Clin Spine Surg. 2024;37(6):256-269. Epub 2023 July 31. PMID: 37559207. https://doi.org/10.1097/bsd.0000000000001490
  6. Matsubara Y, Kato F, Mimatsu K, Kajino G, Nakamura S, Nitta H. Serial changes on MRI in lumbar disc herniations treated conservatively. Neuroradiology. 1995;37(5):378-383. PMID: 7477838. https://doi.org/10.1007/BF00588017
  7. Teplick JG, Haskin ME. Spontaneous regression of herniated nucleus pulposus. AJR Am J Roentgenol. 1985;145:371-375.  https://doi.org/10.2214/ajr.145.2.371
  8. Tkachev AM, Epifanov AV, Akarachkova ES, Smirnova AV, Ilyushin AV, Gordeeva IE. Rezorbtsiya gryzhi mezhpozvonkovogo diska. Fenomen tranzitornogo uvelicheniya razmera. RMZh. 2022;4:7-10. (In Russ.).
  9. Ministerstvo zdravookhraneniya Rossijskoj Federatsii. Klinicheskie rekomendatsii «Diskogennaya poyasnichno-kresttsovaya radikulopatiya», 2023 g. (In Russ.). https://cr.minzdrav.gov.ru/schema/777_1
  10. Gianola S, Bargeri S, Del Castillo G, Corbetta D, Turolla A, Andreano A, Moja L, Castellini G. Effectiveness of treatments for acute and subacute mechanical non-specific low back pain: A systematic review with network meta-analysis. Br J Sports Med. 2022;56(1):41-50.  https://doi.org/10.1136/bjsports-2020-103596
  11. Evans L, O’Donohoe T, Morokoff A, Drummond K. The role of spinal surgery in the treatment of low back pain. Med J Aust. 2023;218(1):40-45.  https://doi.org/10.5694/mja2.51788
  12. Fritz JM, Brennan GP, Hunter SJ. Physical therapy or advanced imaging as first management strategy following a new consultation for low back pain in primary care: associations with future health care utilization and charges. Health Serv Res. 2020;50(6):1927-1940. https://doi.org/10.1111/1475-6773.12301
  13. Jacobs JC, Jarvik JG, Chou R, Boothroyd D, Lo J, Nevedal A, Barnett PG. Observational Study of the Downstream Consequences of Inappropriate MRI of the Lumbar Spine. J Gen Intern Med. 2020;35(12):3605-3612. https://doi.org/10.1007/s11606-020-06181-7
  14. Kreiner DS, Hwang SW, Easa JE, Resnick DK, Baisden JL, Bess S, Cho CH, DePalma MJ, Dougherty P 2nd, Fernand R, Ghiselli G, Hanna AS, Lamer T, Lisi AJ, Mazanec DJ, Meagher RJ, Nucci RC, Patel RD, Sembrano JN, Sharma AK, Summers JT, Taleghani CK, Tontz WL Jr, Toton JF; North American Spine Society. An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy. Spine J. 2014;14(1):180-191. Epub 2013 Nov 14. PMID: 24239490. https://doi.org/10.1016/j.spinee.2013.08.003
  15. Quon JA, Sobolev BG, Levy AR, Fisher CG, Bishop PB, Kopec JA, Dvorak MF, Schechter MT. The effect of waiting time on pain intensity after elective surgical lumbar discectomy. Spine J. 2013;13(12):1736-1748. Epub 2013 July 11. PMID: 23850131. https://doi.org/10.1016/j.spinee.2013.05.038
  16. Ng LCL, Sell P. Predictive value of the duration of sciatica for lumbar discectomy: a prospective cohort study. J Bone Joint Surg Br. 2004;86:546-549.  https://doi.org/10.1302/0301-620x.86b4.14419
  17. Nygaard OP, Kloster R, Solberg T. Duration of leg pain as a predictor of outcome after surgery for lumbar disc herniation: a prospective cohort study with 1-year follow up. J Neurosurg. 2000;92:(suppl):131-134.  https://doi.org/10.3171/spi.2000.92.2.0131
  18. Rihn JA, Hilibrand AS, Radcliff K, Kurd M, Lurie J, Blood E, Albert TJ, Weinstein JN. Duration of symptoms resulting from lumbar disc herniation: effect on treatment outcomes: analysis of the Spine Patient Outcomes Research Trial (SPORT). J Bone Joint Surg Am. 2011;93(20):1906-1914. PMID: 22012528; PMCID: PMC5515548. https://doi.org/10.2106/jbjs.j.00878
  19. Fairbank J, Frost H, Wilson-MacDonald J, Yu LM, Barker K, Collins R; Spine Stabilisation Trial Group. Randomised controlled trial to compare surgical stabilisation of the lumbar spine with an intensive rehabilitation programme for patients with chronic low back pain: the MRC spine stabilisation trial. BMJ. 2005;330(7502):1233. Epub 2005 May 23. Erratum in: BMJ. 2005 June 25;330(7506):1485. PMID: 15911537; PMCID: PMC558090. https://doi.org/10.1136/bmj.38441.620417.8F
  20. Xiong HY, Hendrix J, Schabrun S, Wyns A, Campenhout JV, Nijs J, Polli A. The Role of the Brain-Derived Neurotrophic Factor in Chronic Pain: Links to Central Sensitization and Neuroinflammation. Biomolecules. 2024;14(1):71.  https://doi.org/10.3390/biom14010071
  21. Cashin AG, Folly T, Bagg MK, Wewege MA, Jones MD, Ferraro MC, Leake HB, Rizzo RRN, Schabrun SM, Gustin SM, Day R, Williams CM, McAuley JH. Efficacy, acceptability, and safety of muscle relaxants for adults with non-specific low back pain: systematic review and meta-analysis. BMJ. 2021;374:n1446. https://doi.org/10.1136/bmj.n1446
  22. Cashin AG, Wand BM, O’Connell NE, Lee H, Rizzo RR, Bagg MK, O’Hagan E, Maher CG, Furlan AD, van Tulder MW, McAuley JH. Pharmacological treatments for low back pain in adults: An overview of Cochrane Reviews. Cochrane Database Syst Rev. 2023;4(4):CD013815. https://doi.org/10.1002/14651858.cd013815.pub2
  23. Sharif S, Jazaib Ali MY, Kirazlı Y, Vlok I, Zygourakis C, Zileli M. Acute back pain: The role of medication, physical medicine and rehabilitation: WFNS spine committee recommendations. World Neurosurg X. 2024;6(23):100273. https://doi.org/10.1016/j.wnsx.2024.100273
  24. Iliopoulos K, Koufaki P, Tsilikas S, Avramidis K, Tsagkalis A, Mavragani C, Zintzaras E. A randomized controlled trial evaluating the short-term efficacy of a single-administration intramuscular injection with the fixed combination of thiocolchicoside-diclofenac versus diclofenac monotherapy in patients with acute moderate-to-severe low back pain. BMC Musculoskelet Disord. 2023;24(1):476.  https://doi.org/10.1186/s12891-023-06599-0
  25. van Walsem A, Pandhi S, Nixon RM, Guyot P, Karabis A, Moore RA. Relative benefit-risk comparing diclofenac to other traditional non-steroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors in patients with osteoarthritis or rheumatoid arthritis: A network meta-analysis. Arthritis Res Ther. 2015;17(1):66.  https://doi.org/10.1186/s13075-015-0554-0
  26. Gan TJ. Diclofenac: an update on its mechanism of action and safety profile. Curr Med Res Opin. 2010;26(7):1715-1731. https://doi.org/10.1185/03007995.2010.486301
  27. Schmidt M, Sørensen HT, Pedersen L. Cardiovascular Risks of Diclofenac Versus Other Older COX-2 Inhibitors (Meloxicam and Etodolac) and Newer COX-2 Inhibitors (Celecoxib and Etoricoxib): A Series of Nationwide Emulated Trials. Drug Saf. 2022;45(9):983-994.  https://doi.org/10.1007/s40264-022-01211-1
  28. Grohs L, Cheng L, Cönen S, Haddad BG, Bülow A, Toklucu I, Ernst L, Körner J, Schmalzing G, Lampert A, Machtens JP, Hausmann R. Diclofenac and other non-steroidal anti-inflammatory drugs (NSAIDs) are competitive antagonists of the human P2X3 receptor. Front Pharmacol. 2023;14:1120360. Erratum in: Front Pharmacol. 2023 June 02;14:1225522. https://doi.org/10.3389/fphar.2023.1120360
  29. Schaffler K, Reitmeir P, Gschanes A, Eggenreich U. Comparison of the analgesic effects of a fixed-dose combination of orphenadrine and diclofenac (Neodolpasse) with its single active ingredients diclofenac and orphenadrine: A placebo-controlled study using laser-induced somatosensory-evoked potentials from capsaicin-induced hyperalgesic human skin. Drugs R D. 2005;6(4):189-199. PMID: 15991879. https://doi.org/10.2165/00126839-200506040-00001
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