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Adamyan L.V.

Russian Medical University;
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Sokolov A.D.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation

Arakelyan A.S.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation

Badlaeva A.S.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation

Asaturova A.V.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation

β-Adrenoreceptors types 1 and 2 in the diagnosis of pain syndrome in patientswith various forms of adenomyosis

Authors:

Adamyan L.V., Sokolov A.D., Arakelyan A.S., Badlaeva A.S., Asaturova A.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2025;31(1): 35‑43

DOI: 10.17116/repro20253101135

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Table of contents

Β-ADRENORECEPTORS TYPES 1 AND 2 IN THE DIAGNOSIS OF PAIN SYNDROME IN PATIENTSWITH VARIOUS FORMS OF ADENOMYOSIS
Β-ADRENORECEPTORS TYPES 1 AND 2 IN THE DIAGNOSIS OF PAIN SYNDROME IN PATIENTSWITH VARIOUS FORMS OF ADENOMYOSIS

To cite this article:

Adamyan LV, Sokolov AD, Arakelyan AS, Badlaeva AS, Asaturova AV. β-Adrenoreceptors types 1 and 2 in the diagnosis of pain syndrome in patientswith various forms of adenomyosis. Russian Journal of Human Reproduction. 2025;31(1):35‑43. (In Russ.)
https://doi.org/10.17116/repro20253101135

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

Analysis of immunohistochemical expression of β1- and β2-adrenergic receptors (ADRB1 and ADRB2) in adenomyotic tissues in reproductive-age patients.

MATERIAL AND METHODS

The study included histological preparations and paraffin blocks from 30 patients with diffuse adenomyosis, 30 patients with nodular adenomyosis and 30 patients from the comparison group. Histological and immunohistochemical studies of excised adenomyosis tissue were performed in the 1st pathological anatomy department of the Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation.

RESULTS

The study showed increased expression of β1- and β2-adrenergic receptors in adenomyosis foci compared to the control group, while a direct relationship was established when assessing the relationship between ADRB2 expression and ADRB1 expression. A direct relationship was also established between the severity of pain syndrome (assessed by the VAS scale) in patients with various forms of adenomyosis and the expression of β1- and β2-adrenergic receptors in the tissue of adenomyosis.

CONCLUSION

The data obtained by us allow us to objectify the severity of pain syndrome in patients with various forms of adenomyosis, since the level of expression of β1- and β2-adrenergic receptors positively correlates with the severity of pain syndrome. These findings make it possible to optimize the tactics of drug treatment of patients with adenomyosis and clarify the pathogenesis of pain syndrome in adenomyosis.

Keywords:

adenomyosis
pain syndrome
β-adrenergic receptors

Authors:

Adamyan L.V.

Russian Medical University;
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Sokolov A.D.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation

Arakelyan A.S.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation

Badlaeva A.S.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation

Asaturova A.V.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation

Received:

01.02.2025

Accepted:

17.02.2025

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