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Adamyan L.V.
Russian Medical University;
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Sokolov A.D.
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation
Arakelyan A.S.
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation
Badlaeva A.S.
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation
Asaturova A.V.
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation
β-Adrenoreceptors types 1 and 2 in the diagnosis of pain syndrome in patientswith various forms of adenomyosis
Journal: Russian Journal of Human Reproduction. 2025;31(1): 35‑43
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To cite this article:
Adamyan LV, Sokolov AD, Arakelyan AS, Badlaeva AS, Asaturova AV. β-Adrenoreceptors types 1 and 2 in the diagnosis of pain syndrome in patientswith various forms of adenomyosis. Russian Journal of Human Reproduction.
2025;31(1):35‑43. (In Russ.)
https://doi.org/10.17116/repro20253101135
Analysis of immunohistochemical expression of β1- and β2-adrenergic receptors (ADRB1 and ADRB2) in adenomyotic tissues in reproductive-age patients.
The study included histological preparations and paraffin blocks from 30 patients with diffuse adenomyosis, 30 patients with nodular adenomyosis and 30 patients from the comparison group. Histological and immunohistochemical studies of excised adenomyosis tissue were performed in the 1st pathological anatomy department of the Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation.
The study showed increased expression of β1- and β2-adrenergic receptors in adenomyosis foci compared to the control group, while a direct relationship was established when assessing the relationship between ADRB2 expression and ADRB1 expression. A direct relationship was also established between the severity of pain syndrome (assessed by the VAS scale) in patients with various forms of adenomyosis and the expression of β1- and β2-adrenergic receptors in the tissue of adenomyosis.
The data obtained by us allow us to objectify the severity of pain syndrome in patients with various forms of adenomyosis, since the level of expression of β1- and β2-adrenergic receptors positively correlates with the severity of pain syndrome. These findings make it possible to optimize the tactics of drug treatment of patients with adenomyosis and clarify the pathogenesis of pain syndrome in adenomyosis.
Keywords:
Authors:
Adamyan L.V.
Russian Medical University;
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Sokolov A.D.
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation
Arakelyan A.S.
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation
Badlaeva A.S.
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation
Asaturova A.V.
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation
Received:
01.02.2025
Accepted:
17.02.2025
List of references:
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