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Gromova O.A.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna;
kafedra farmakologii i klinicheskoĭ farmakologii Ivanovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Torshin I.Iu.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna

Gogoleva I.V.

Ivanovskaia gosudarstvennaia meditsinskaia akademiia, Ivanovo

Pronin A.V.

Ivanovo State Medical Academy, Ivanovo

Stel'mashuk E.V.

NTs nevrologii RAMN

Isaev N.K.

Neurology Research Center, Russian Academy of Sciences, Moscow

Genrikhs E.E.

Neurology Research Center, Russian Academy of Sciences, Moscow

Demidov V.I.

Ivanovskaia gosudarstvennaia meditsinskaia akademiia, Ivanovo

Volkov A.Iu.

GBOU VPO "Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova", Moskva, Rossiĭskaia Federatsiia

Khaspekov G.L.

Ivanovo State Medical Academy, Ivanovo

Alexandrova O.P.

Neurology Research Center, Russian Academy of Sciences, Moscow

Pharmacokinetic and pharmacodynamic synergism between neuropeptides and lithium in the neurotrophic and neuroprotective action of cerebrolysin

Authors:

Gromova O.A., Torshin I.Iu., Gogoleva I.V., Pronin A.V., Stel'mashuk E.V., Isaev N.K., Genrikhs E.E., Demidov V.I., Volkov A.Iu., Khaspekov G.L., Alexandrova O.P.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2015;115(3): 65‑72

DOI: 10.17116/jnevro20151153165-72

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Table of contents

PHARMACOKINETIC AND PHARMACODYNAMIC SYNERGISM BETWEEN NEUROPEPTIDES AND LITHIUM IN THE NEUROTROPHIC AND NEUROPROTECTIVE ACTION OF CEREBROLYSIN
PHARMACOKINETIC AND PHARMACODYNAMIC SYNERGISM BETWEEN NEUROPEPTIDES AND LITHIUM IN THE NEUROTROPHIC AND NEUROPROTECTIVE ACTION OF CEREBROLYSIN

To cite this article:

Gromova OA, Torshin IIu, Gogoleva IV, et al. Pharmacokinetic and pharmacodynamic synergism between neuropeptides and lithium in the neurotrophic and neuroprotective action of cerebrolysin. S.S. Korsakov Journal of Neurology and Psychiatry. 2015;115(3):65‑72. (In Russ.)
https://doi.org/10.17116/jnevro20151153165-72

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
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Abstract:

Objective. To study the synergism between neuropeptides and lithium ions. Material and methods. An experimental model of stroke (chronic bilateral occlusion of the common carotid arteries in rats), neuronal culture studies, histomorphological analyses, determination of micronutrient profile of brain substrates were used. Results. A complex of experimental studies revealed that the effect of cerebrolysin is influenced by the synergism between lithium ions and the neuropeptide content of this drug. Pharmacokinetic synergism promotes the accumulation of lithium in brain tissues during cerebrolysin treatment. The existence of the pharmacokinetic synergism is evident from the potentiation of neuroprotective effects of the drug under the action of lithium ions established in the model of stroke. Conclusion. Lithium ions potentiate neuroprotective effects of cerebrolysin.

Keywords:

neuropeptides
lithium
histology
neurocytology
model of chronic bilateral occlusion of common carotid arteries

Authors:

Gromova O.A.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna;
kafedra farmakologii i klinicheskoĭ farmakologii Ivanovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Torshin I.Iu.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna

Gogoleva I.V.

Ivanovskaia gosudarstvennaia meditsinskaia akademiia, Ivanovo

Pronin A.V.

Ivanovo State Medical Academy, Ivanovo

Stel'mashuk E.V.

NTs nevrologii RAMN

Isaev N.K.

Neurology Research Center, Russian Academy of Sciences, Moscow

Genrikhs E.E.

Neurology Research Center, Russian Academy of Sciences, Moscow

Demidov V.I.

Ivanovskaia gosudarstvennaia meditsinskaia akademiia, Ivanovo

Volkov A.Iu.

GBOU VPO "Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova", Moskva, Rossiĭskaia Federatsiia

Khaspekov G.L.

Ivanovo State Medical Academy, Ivanovo

Alexandrova O.P.

Neurology Research Center, Russian Academy of Sciences, Moscow

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