The activity of blood serum cholinesterases and neprilysin as potential biomarkers of mild-cognitive impairment and Alzheimer’s disease

Zhuravin I.А.; Nalivaeva N.N.; Kozlova D.I.; Kochkina E.G.; Fedorova Ia.B.; Gavrilova S.I.

doi:https://doi.org/10.17116/jnevro2015115112110-117

Zhuravin I.А.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg;
St. Petersburg State Pediatric Medical University, St. Petersburg

Zhuravin I.А.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg;
St. Petersburg State Pediatric Medical University, St. Petersburg

Nalivaeva N.N.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg

Nalivaeva N.N.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg

Kozlova D.I.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg

Kozlova D.I.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg

Kochkina E.G.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg

Kochkina E.G.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg

Fedorova Ia.B.

Otdel po izucheniiu bolezni Al'tsgeĭmera i assotsiirovannykh s neĭ rasstroĭstv Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Gavrilova S.I.

Otdel po izucheniiu bolezni Al'tsgeĭmera i assotsiirovannykh s neĭ rasstroĭstv Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

SPIN RSCI: 6094-4303
Scopus AuthorID: 7004829216
ResearcherID: B-4548-2016
ORCID: 0000-0001-6683-0240

The activity of blood serum cholinesterases and neprilysin as potential biomarkers of mild-cognitive impairment and Alzheimer’s disease

Authors:

Zhuravin I.А., Zhuravin I.А., Nalivaeva N.N., Nalivaeva N.N., Kozlova D.I., Kozlova D.I., Kochkina E.G., Kochkina E.G., Fedorova Ia.B., Gavrilova S.I.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2015;115(12): 110‑117

DOI: 10.17116/jnevro2015115112110-117

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To cite this article:

Zhuravin IА, Zhuravin IА, Nalivaeva NN, et al. The activity of blood serum cholinesterases and neprilysin as potential biomarkers of mild-cognitive impairment and Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2015;115(12):110‑117. (In Russ.)
https://doi.org/10.17116/jnevro2015115112110-117

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Objective — to analyze the activity of acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and neprilysin (NEP) in the blood serum in elderly people with different types of cognitive impairment and evaluate the effect of ceraxon on the biochemical parameters. Material and methods. Three groups of patients: without cognitive disorders (controls — CG), with amnestic mild cognitive impairment (а-MCI) and with Alzheimer’s disease (AD were studied). Results and conclusion. The activity of AChE, BChE and NEP was reduced in the blood serum of patients with a-MCI and, to the greater extent, in patients with AD compared to CG and correlated with the level of cognitive dysfunction evaluated by MMSE, ADAS-cog, and other tests. For the first time, it has been shown that treatment of a-MCI patients with ceraxon (citicolin) results in an increase of the activity of blood serum AChE, BChE and NEP to the values observed in the CG. Thus, the activities of blood serum AChE, BChE and NEP reflect the level of cognitive dysfunction and can be used as prognostic biomarkers of the level of dementia progression in patients with impaired memory.

Keywords:

Alzheimer’s disease

mild cognitive impairment

acetylcholinesterase

butyrylcholinesterase

neprilysin

blood serum

ceraxon (citicolin)

cognitive functions

Authors:

Zhuravin I.А.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg;
St. Petersburg State Pediatric Medical University, St. Petersburg

Zhuravin I.А.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg;
St. Petersburg State Pediatric Medical University, St. Petersburg

Nalivaeva N.N.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg

Nalivaeva N.N.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg

Kozlova D.I.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg

Kozlova D.I.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg

Kochkina E.G.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg

Kochkina E.G.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg

Fedorova Ia.B.

Otdel po izucheniiu bolezni Al'tsgeĭmera i assotsiirovannykh s neĭ rasstroĭstv Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Gavrilova S.I.

Otdel po izucheniiu bolezni Al'tsgeĭmera i assotsiirovannykh s neĭ rasstroĭstv Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

SPIN RSCI: 6094-4303
Scopus AuthorID: 7004829216
ResearcherID: B-4548-2016
ORCID: 0000-0001-6683-0240

Close metadata