Objective — to study an influence of cytoflavin on normalization of cognitive functions, psychoemotional condition and a quality of life in stroke patients. Material and methods. It was analysed the results of treatment of 1450 stroke patients. The cognitive functions was followed up using MMSE and MoCA scales, psychoemotional condition — Beck Depression Questionnaire and Wakefield Depression Scale, Hamilton Scale of Anxiety, quality of life — Sickness Impact Profile. Results and conclusion. The results of the study revealed that the use of cytoflavin was well founded in the treatment of stroke patients for improvement of cognitive functions, psychoemotional condition and the quality of life.