The paper is devoted to the urgent problem of pain syndromes of multimodal character developed in different pathologies. The diagnosis and treatment of pain is frequently complicated by nociceptive, neuropathic and dysfunctional components. Special attention is drawn to the dysfunctional component and its relation to depression. In this context, the authors consider psychological aspects of pain syndrome formation and methods of treatment using pharmacological medications and pain-coping strategies as well. Different coping strategies of active and passive pain-coping styles depending on sex, personality features, nosologic forms are presented. The necessity of using the active coping-strategies to relieve pain of different genesis is highlighted.