Objective. To identify typical clinical and pathogenetic variants of organic mental disorders (OMD), comorbid with alcohol dependence. Material and methods. A study included 302 men who underwent forensic-psychiatric examination. Clinical/psychopathological, clinical/dynamic and statistical methods were used. Results and сonclusion. Significant disorders of social adaptation, commitment of serious unlawful acts, problems of diagnosis and forensic psychiatric assessment were typical of all comorbid disorders studied. We determined two main variants of this comorbid pathology: 1) primary OMD, complicated with alcohol dependence; 2) alcohol dependence, which caused secondary OMD. These variants differ not only in the etiopathogenesis, but in the clinical design and dynamic of disorders.