Clinical efficacy and pharmacoeconomic characteristics of the neuroprotection with low doses of cortexin in the treatment of acute ischemic stroke

Aliferova V.M.; Dadasheva M.N.; Doronin B.M.; Kovalenko A.V.; Lokshtanova T.M.; Martynov M.Iu.; Meshkova K.S.; Salimov K.A.; Stakhovskaya L.V.; Chefranova Zh.Yu.; Shamalov N.A.

doi:https://doi.org/

Aliferova V.M.

Sibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Tomsk

Dadasheva M.N.

Moskovskiĭ oblastnoĭ nauchno-issledovatel'skiĭ klinicheskiĭ institut im. M.F. Vladimirskogo

Doronin B.M.

Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Kovalenko A.V.

Hematology Research Center, Ministry of Health of the Russian Federation, Moscow

Lokshtanova T.M.

Gorodskaia bol'nitsa #1 im. N.I. Pirogova, Samara

Martynov M.Iu.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta

SPIN RSCI: 8010-8340
Scopus AuthorID: 7004761286
ResearcherID: K-8390-2018
ORCID: 0000-0003-2797-7877

Meshkova K.S.

Kafedra fundamental'noĭ i klinicheskoĭ nevrologii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta im. N.I. Pirogova

Salimov K.A.

GBOU VPO "Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova" MZ RF, Moskva

Stakhovskaya L.V.

Pirogov Russian National Research Medical University, Moscow, Russia

Chefranova Zh.Yu.

Department of Nervous Diseases and Restorative Medicine of the Belgorod State University;
Regional Vascular Center of the Belgorod Regional Clinical Hospital of St. Joasaph

Shamalov N.A.

Research Institute of cerebrovascular pathology and stroke of the Pirogov Russian national research medical University, Moscow, Russia

SPIN RSCI: 2865-9817
Scopus AuthorID: 6507183111
ORCID: 0000-0001-6250-0762

Clinical efficacy and pharmacoeconomic characteristics of the neuroprotection with low doses of cortexin in the treatment of acute ischemic stroke

Authors:

Aliferova V.M., Dadasheva M.N., Doronin B.M., Kovalenko A.V., Lokshtanova T.M., Martynov M.Iu., Meshkova K.S., Salimov K.A., Stakhovskaya L.V., Chefranova Zh.Yu., Shamalov N.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2014;114(4): 41‑46

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To cite this article:

Aliferova VM, Dadasheva MN, Doronin BM, et al. . Clinical efficacy and pharmacoeconomic characteristics of the neuroprotection with low doses of cortexin in the treatment of acute ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2014;114(4):41‑46. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Objective. To assess the efficacy of the cytoprotective neuropeptide cortexin in the complex treatment in acute and early rehabilitation stages of ischemic stroke (II). Material and methods. A multicenter prospective double-blind placebo-controlled trial has been carried out. Two hundreds and seventy-two patients with II have been enrolled in the trial. Cortexin was administered in low doses (10 mg three times a day intramuscular, using the following schemes: group 1: 2 courses of cortexin; group 2: 1 course of cortexin with the following course of placebo; group 3: two courses of placebo. The duration of treatment was 70 days. Patients were examined during 4 visits using clinical tests and instrumental methods. Results. High efficacy and safety of cortexin in the complex treatment of patients with II has been shown. The best therapeutic effect was seen in group 1 (two 10-day courses of cortexin). The results were confirmed by the pharmacoeconomic analysis of treatment tactics based on the estimation of "net monetary benefit". Conclusion. Cortexin is recommended for treatment and rehabilitation of patients with II.

Keywords:

ischemic stroke

treatment

neuroprotection

cortexin