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Ivanets N.N.

Kafedra psikhiatrii i meditsinskoĭ psikhologii Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Tikhonova Iu.G.

Kafedra psikhiatrii i narkologii GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdrava RF;
Nauchno-obrazovatel'nyĭ klinicheskiĭ tsentr "Psikhicheskoe zdorov'e", Moskva

Kinkul'kina M.A.

Kafedra psikhiatrii i meditsinskoĭ psikhologii Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Avdeeva T.I.

Treatment of depression: the current state and perspectives of the development of pharmacological studies

Authors:

Ivanets N.N., Tikhonova Iu.G., Kinkul'kina M.A., Avdeeva T.I.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2014;114(10): 108‑116

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TREATMENT OF DEPRESSION: THE CURRENT STATE AND PERSPECTIVES OF THE DEVELOPMENT OF PHARMACOLOGICAL STUDIES
TREATMENT OF DEPRESSION: THE CURRENT STATE AND PERSPECTIVES OF THE DEVELOPMENT OF PHARMACOLOGICAL STUDIES

To cite this article:

Ivanets NN, Tikhonova IuG, Kinkul'kina MA, Avdeeva TI. Treatment of depression: the current state and perspectives of the development of pharmacological studies. S.S. Korsakov Journal of Neurology and Psychiatry. 2014;114(10):108‑116. (In Russ.)

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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A review of literature over the last two decades is presented. It is emphasized that psyachopharmacotherapy currently remains a main method of treatment of severe and moderate depression. Pharmacogenetic studies are directed mainly towards the identification of probable targets of antidepressant action and gene polymorphisms (CYP P450, TPH etc). The literature data on pharmacogenetics are analyzed based on pharmacokinetcs and pharmacodynamics of andidepressants as well as in the aspect of identification of probable predictors for treatment response.

Keywords:

depression
therapy
pharmacogenetics
pharmacokinetcs
pharmacodynamics

Authors:

Ivanets N.N.

Kafedra psikhiatrii i meditsinskoĭ psikhologii Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Tikhonova Iu.G.

Kafedra psikhiatrii i narkologii GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdrava RF;
Nauchno-obrazovatel'nyĭ klinicheskiĭ tsentr "Psikhicheskoe zdorov'e", Moskva

Kinkul'kina M.A.

Kafedra psikhiatrii i meditsinskoĭ psikhologii Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Avdeeva T.I.

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