Hypofunction of the dopamine system was induced by haloperidol or reserpine in Wistar rats. Reserpine increased a number of glial fibrillary acidic protein (GFAP) containing astrocytes by 49% and reduced glutamine synthase astrocytes and monoamine oxidase activity by 23% and 1/3, respectively. Haloperidol had no effect on morpho-chemical characteristics of astrocytes but increased a number of oligodendrocytes. It has been supposed that the activation of astroglia by reserpine in a dopamine hypofunction model is caused by the dysfunction of the corticostriatal glutamatergic system as a result of inhibition of the dopaminergic transmission in the basal nuclei. The changes in the neuroglial interactions in the striatum that lead to the disbalance of neuromediator systems in the basal nuclei may underlie the dysfunction of the basal nuclei in some diseases including Parkinson's disease.