Information aspects of tissue microcirculation were investigated in 64 patients with complex regional pain syndrome after sympathectomy using a wavelet-analysis of skin microvascular blood flow oscillations. The early reorganization of information in the trophotropic direction at the level of microvascular tissue systems, its predomination and conservation along the microvascular networks facilitate the optimal realization of adaptive reactions and, as a result, lead to the best treatment efficacy. In these cases, the complete elimination of disease and achievement of excellent treatment results are possible. The best treatment efficacy could not be reached without the above-mentioned information changes. On the contrary, the predomination and conservation of ergotropic information in the early stages after surgery predicted worse outcomes of sympathectomy. Tissue desympathisation is not required for the formation of trophotropic purposefulness of information in microvascular networks; it is enough to achieve a certain threshold to decrease the sympathetic activity.