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Svistushkin V.M.

Sechenov First Moscow State Medical University (Sechenov University)

Eremeeva K.V.

Sechenov First Moscow State Medical University (Sechenov University)

Yang X.

Sechenov First Moscow State Medical University (Sechenov University)

Smolyarchuk E.A.

Sechenov First Moscow State Medical University (Sechenov University)

Nedorubov A.A.

Sechenov First Moscow State Medical University (Sechenov University)

Machikhin A.S.

Scientific and Technological Center of Unique Instrumentation of the Russian Academy of Sciences

Guryleva A.V.

Scientific and Technological Center of Unique Instrumentation of the Russian Academy of Sciences

Derevesnikova D.A.

Scientific and Technological Center of Unique Instrumentation of the Russian Academy of Sciences

Kulikova E.D.

Scientific and Technological Center of Unique Instrumentation of the Russian Academy of Sciences;
Bauman Moscow State Technical University (National Research University)

Development of an experimental rabbit model of rhinitis medicamentosa

Authors:

Svistushkin V.M., Eremeeva K.V., Yang X., Smolyarchuk E.A., Nedorubov A.A., Machikhin A.S., Guryleva A.V., Derevesnikova D.A., Kulikova E.D.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2025;90(3): 46‑52

DOI: 10.17116/otorino20259003146

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Table of contents

DEVELOPMENT OF AN EXPERIMENTAL RABBIT MODEL OF RHINITIS MEDICAMENTOSA
DEVELOPMENT OF AN EXPERIMENTAL RABBIT MODEL OF RHINITIS MEDICAMENTOSA

To cite this article:

Svistushkin VM, Eremeeva KV, Yang X, et al. . Development of an experimental rabbit model of rhinitis medicamentosa. Russian Bulletin of Otorhinolaryngology. 2025;90(3):46‑52. (In Russ.)
https://doi.org/10.17116/otorino20259003146

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

BACKGROUND

Rhinitis medicamentosa (RM), resulting from prolonged use of nasal decongestants, represents a significant clinical problem. The pathogenetic mechanisms of RM remain insufficiently studied, and existing methods for assessing the state of the nasal mucosa require improvement. The development of an experimental model of RM is necessary for testing new therapeutic approaches.

OBJECTIVE

To develop an experimental model of RM in rabbits, evaluate morphological changes in the nasal mucosa, and test the photoplethysmography method for non-invasive diagnosis of microcirculatory disorders.

MATERIAL AND METHODS

The study was conducted on 18 Soviet Chinchilla rabbits. The RM model was induced by intranasal administration of 0.1% xylometazoline solution (200 μl/nostril, 2 times/day, 14 days). The control group received saline. Histological analysis of the mucosa was performed on days 8 and 15. The state of microcirculation was assessed by photoplethysmography using a cold test. Data registration was carried out in vivo with subsequent digital signal processing.

RESULTS

Progressive histological changes were revealed: epithelial dystrophy, a decrease in the number of goblet cells, and vascular alterations. The photoplethysmography demonstrated a significant decrease in the ratio of photoplethysmogram amplitudes in the RM group (median 0.76 vs. 1.48 in the control; p<0.01), reflecting impaired microcirculation.

CONCLUSION

An experimental model of RM in rabbits was developed, confirmed by histological and photoplethysmographic data. The photoplethysmography showed high sensitivity for non-invasive assessment of the mucosal state, opening up prospects for its application in clinical practice and further studies of RM therapy.

Keywords:

rhinitis medicamentosa
nasal decongestants
experimental model
photoplethysmography
microcirculation

Authors:

Svistushkin V.M.

Sechenov First Moscow State Medical University (Sechenov University)

Eremeeva K.V.

Sechenov First Moscow State Medical University (Sechenov University)

Yang X.

Sechenov First Moscow State Medical University (Sechenov University)

Smolyarchuk E.A.

Sechenov First Moscow State Medical University (Sechenov University)

Nedorubov A.A.

Sechenov First Moscow State Medical University (Sechenov University)

Machikhin A.S.

Scientific and Technological Center of Unique Instrumentation of the Russian Academy of Sciences

Guryleva A.V.

Scientific and Technological Center of Unique Instrumentation of the Russian Academy of Sciences

Derevesnikova D.A.

Scientific and Technological Center of Unique Instrumentation of the Russian Academy of Sciences

Kulikova E.D.

Scientific and Technological Center of Unique Instrumentation of the Russian Academy of Sciences;
Bauman Moscow State Technical University (National Research University)

Received:

02.04.2025

Accepted:

04.05.2025

Close metadata

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