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Avakian G.N.

Department of Neurology and Neurosurgery of the N.I. Pirogov Russian National Research Medical University

Oleynikova O.M.

Department of Neurology and Neurosurgery of the N.I. Pirogov Russian National Research Medical University

Lagutin Yu.V.

City Polyclinic No. 68, Moscow

Khromykh E.A.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Bogomazova M.A.

Pirogov Russian National Research Medical University, Moscow

Delger A.B.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Avakian G.G.

Department of Neurology and Neurosurgery of the N.I. Pirogov Russian National Research Medical University

Season fluctuations of carbamazepine and valproate concentration in patients with epilepsy

Authors:

Avakian G.N., Oleynikova O.M., Lagutin Yu.V., Khromykh E.A., Bogomazova M.A., Delger A.B., Avakian G.G.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2013;113(11): 34‑39

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SEASON FLUCTUATIONS OF CARBAMAZEPINE AND VALPROATE CONCENTRATION IN PATIENTS WITH EPILEPSY
SEASON FLUCTUATIONS OF CARBAMAZEPINE AND VALPROATE CONCENTRATION IN PATIENTS WITH EPILEPSY

To cite this article:

Avakian GN, Oleynikova OM, Lagutin YuV, Khromykh EA, Bogomazova MA, Delger AB, Avakian GG. Season fluctuations of carbamazepine and valproate concentration in patients with epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2013;113(11):34‑39. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

We studied 107 patients with epilepsy who received monotherapy with valproic acid drugs (58) and carbamazepine (49). The seasonal distribution of number and severity of seizures assessed with the NHS3 scale in dependence of Cmin and Cmax content of antiepileptic drugs carbamazepine and valproates in the serum of patients was estimated. There was a significant increase in the number of seizures and their severity in the cycle spring>autumn>summer>winter. The serum content of carbamazepine and valproates was significantly lower in spring compared to autumn.

Keywords:

epilepsy
seasonality
seizures
carbamazepine
valproic acid
blood concentration

Authors:

Avakian G.N.

Department of Neurology and Neurosurgery of the N.I. Pirogov Russian National Research Medical University

Oleynikova O.M.

Department of Neurology and Neurosurgery of the N.I. Pirogov Russian National Research Medical University

Lagutin Yu.V.

City Polyclinic No. 68, Moscow

Khromykh E.A.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Bogomazova M.A.

Pirogov Russian National Research Medical University, Moscow

Delger A.B.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Avakian G.G.

Department of Neurology and Neurosurgery of the N.I. Pirogov Russian National Research Medical University

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