Fifty-eight patients, 13 girls and 45 boys, with early-onset schizophrenia (mean 5.4 years) were followed up for 9.5 years. The men age at end point was 19.7 years. Full remission or recovery was not identified in any of the patients. The partial remission was observed in 14 (24%) patients and 44 (76%) patients had chronic course without remissions. Two thirds of patients were disabled including 9 patients with severe, 25 patients with moderate and 1 patient with mild disability. Most of the patients (62%) became disabled in childhood. Fourteen patients need the constant care and control from caregivers; 24 patients were able to work in special conditions, 20 patients can live independently and support themselves; 57 patients lived with parents and 1 patient was married. It has been concluded that notwithstanding the intensive psychopharmacotherapy and rehabilitative programs, patients with early-onset schizophrenia show poor outcomes. Therefore, new social-therapeutic approaches for providing care to these patients are needed.