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Shumakher1 G.I.

Altaĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet;
Otdelencheskaia klinicheskaia bol'nitsa stantsii Barnaul;
Altaĭskiĭ kraevoĭ kardiologicheskiĭ tsentr, Barnaul

Goriacheva1 M.V.

Sencheva2 N.A.

Travnikova3 T.Iu.

Kuznetsova2 M.P.

Association of blood serum biochemical markers with neurologic syndromes in the exacerbation of dorsolumbar osteochondrosis

Authors:

Shumakher1 G.I., Goriacheva1 M.V., Sencheva2 N.A., Travnikova3 T.Iu., Kuznetsova2 M.P.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2012;112(3): 57‑59

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To cite this article:

Shumakher1 GI, Goriacheva1 MV, Sencheva2 NA, Travnikova3 TIu, Kuznetsova2 MP. Association of blood serum biochemical markers with neurologic syndromes in the exacerbation of dorsolumbar osteochondrosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2012;112(3):57‑59. (In Russ.)

 
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The content of C-reactive albumin (CRA) and endothelin-1 in patients with neurologic syndromes of dorsolumbar osteochondrosis (lumbodynia, lumboischialgia, lumbosacral radiculopathy) during exacerbation was investigated. CRA concentration in blood serum was determined by a highly sensitive quantitative method (in the interval from 0.1 g/l), based on the reaction of immunoprecipitation. Endothelin-1 content in the blood serum was determined by means of immunoenzymometric analysis method. The statistically significant (p<0,05) increase in concentrations of C-reactive albumin and endothelin-1 in the peripheral blood serum was found in 43 patients with lumbosacral radiculopathy compared to the control group and groups of patients with syndromes of lumbodynia and lumboischialgia. The direct correlation (r=0,71; p<0,01) between the content of CRA and endothelin-1 in the peripheral blood serum in patients with lumbosacral radiculopathy was established.

Keywords:

lumbalgia
lumboischialgia
lumbosacral radiculopathy
C-reactive protein
endothelin-1
correlation

Authors:

Shumakher1 G.I.

Altaĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet;
Otdelencheskaia klinicheskaia bol'nitsa stantsii Barnaul;
Altaĭskiĭ kraevoĭ kardiologicheskiĭ tsentr, Barnaul

Goriacheva1 M.V.

Sencheva2 N.A.

Travnikova3 T.Iu.

Kuznetsova2 M.P.

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