Association of blood serum biochemical markers with neurologic syndromes in the exacerbation of dorsolumbar osteochondrosis

Shumakher1 G.I.; Goriacheva1 M.V.; Sencheva2 N.A.; Travnikova3 T.Iu.; Kuznetsova2 M.P.

doi:https://doi.org/

Shumakher1 G.I.

Altaĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet;
Otdelencheskaia klinicheskaia bol'nitsa stantsii Barnaul;
Altaĭskiĭ kraevoĭ kardiologicheskiĭ tsentr, Barnaul

Goriacheva1 M.V.

Sencheva2 N.A.

Travnikova3 T.Iu.

Kuznetsova2 M.P.

Association of blood serum biochemical markers with neurologic syndromes in the exacerbation of dorsolumbar osteochondrosis

Authors:

Shumakher1 G.I., Goriacheva1 M.V., Sencheva2 N.A., Travnikova3 T.Iu., Kuznetsova2 M.P.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2012;112(3): 57‑59

Read: 7188 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Shumakher1 GI, Goriacheva1 MV, Sencheva2 NA, Travnikova3 TIu, Kuznetsova2 MP. Association of blood serum biochemical markers with neurologic syndromes in the exacerbation of dorsolumbar osteochondrosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2012;112(3):57‑59. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Anti-aging klotho protein. Associations with sleep patterns in obstructive sleep apnea: A pilot study. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):98-102

Estimation of pro-inflammatory cytokines and C-reactive protein levels in patients with acute demyelination episode. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):118-121

Evaluation of prognostic factors of preterm birth. Russian Journal of Human Reproduction. 2025;(2):37-43

Interleukin-6 as a biochemical marker of intestinal anastomotic leakage. Pirogov Russian Journal of Surgery. 2025;(9):87-93

The use of grape polyphenols in combination with magnetic therapy in patients with bronchial asthma who have suffered a new coronavirus infection. Problems of Balneology, Physiotherapy and Exercise Therapy. 2025;(4):14-19

Inflammation in pathogenesis of cardiovascular diseases and prospects for targeted anti-inflammatory therapy. Russian Cardiology Bulletin. 2025;(4):5-9

Abstract:

The content of C-reactive albumin (CRA) and endothelin-1 in patients with neurologic syndromes of dorsolumbar osteochondrosis (lumbodynia, lumboischialgia, lumbosacral radiculopathy) during exacerbation was investigated. CRA concentration in blood serum was determined by a highly sensitive quantitative method (in the interval from 0.1 g/l), based on the reaction of immunoprecipitation. Endothelin-1 content in the blood serum was determined by means of immunoenzymometric analysis method. The statistically significant (p<0,05) increase in concentrations of C-reactive albumin and endothelin-1 in the peripheral blood serum was found in 43 patients with lumbosacral radiculopathy compared to the control group and groups of patients with syndromes of lumbodynia and lumboischialgia. The direct correlation (r=0,71; p<0,01) between the content of CRA and endothelin-1 in the peripheral blood serum in patients with lumbosacral radiculopathy was established.

Keywords:

lumbalgia

lumboischialgia

lumbosacral radiculopathy

C-reactive protein

endothelin-1

correlation