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Gavrilova S.I.

Otdel po izucheniiu bolezni Al'tsgeĭmera i assotsiirovannykh s neĭ rasstroĭstv Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Kalyn Ia.B.

Otdel po izucheniiu bolezni Al'tsgeĭmera i assotsiirovannykh s neĭ rasstroĭstv Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Kolykhalov I.V.

Otdel po izucheniiu bolezni Al'tsgeĭmera i assotsiirovannykh s neĭ rasstroĭstv Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Roshchina I.F.

Otdel po izucheniiu bolezni Al'tsgeĭmera i assotsiirovannykh s neĭ rasstroĭstv Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Selezneva N.D.

Otdel po izucheniiu bolezni Al'tsgeĭmera i assotsiirovannykh s neĭ rasstroĭstv Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Acetyl-L-carnitine (carnicetine) in the treatment of early stages of Alzheimer's disease and vascular dementia

Authors:

Gavrilova S.I., Kalyn Ia.B., Kolykhalov I.V., Roshchina I.F., Selezneva N.D.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(9): 16‑22

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Table of contents

ACETYL-L-CARNITINE (CARNICETINE) IN THE TREATMENT OF EARLY STAGES OF ALZHEIMER'S DISEASE AND VASCULAR DEMENTIA
ACETYL-L-CARNITINE (CARNICETINE) IN THE TREATMENT OF EARLY STAGES OF ALZHEIMER'S DISEASE AND VASCULAR DEMENTIA

To cite this article:

Gavrilova SI, Kalyn IaB, Kolykhalov IV, Roshchina IF, Selezneva ND. Acetyl-L-carnitine (carnicetine) in the treatment of early stages of Alzheimer's disease and vascular dementia. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(9):16‑22. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

Efficacy, safety and tolerability of acetyl-L-carnitine (ALC) were studied during the double-blind placebo-controlled 12-week trial in patients with mild (initial) dementia caused by the Alzheimer's disease (AD) and vascular dementia (VD). ALC was administered in doses from 2250 to 3000 mg per day. Patient's state was assessed with some scales (MMSE, CGI etc) and a battery of neuropsychological tests. The treatment effect of ALC was 2,8 times higher than in placebo-treated patients. The clinical improvement by CGI scores was significantly better in AD patients compared to VD and did not depend on the severity of baseline cognitive deficit. The drug was well-tolerated. Carnicetine can be recommended in the abovementioned doses for treatment of early stages of AD and VD.

Keywords:

Alzheimer's disease
Alzheimer's disease
vascular dementia
vascular dementia
initial stage of disease
initial stage of disease
mild cognitive impairment
mild cognitive impairment
acetyl-L-carnitine (carnicetine)
acetyl-L-carnitine (carnicetine)

Authors:

Gavrilova S.I.

Otdel po izucheniiu bolezni Al'tsgeĭmera i assotsiirovannykh s neĭ rasstroĭstv Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Kalyn Ia.B.

Otdel po izucheniiu bolezni Al'tsgeĭmera i assotsiirovannykh s neĭ rasstroĭstv Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Kolykhalov I.V.

Otdel po izucheniiu bolezni Al'tsgeĭmera i assotsiirovannykh s neĭ rasstroĭstv Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Roshchina I.F.

Otdel po izucheniiu bolezni Al'tsgeĭmera i assotsiirovannykh s neĭ rasstroĭstv Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Selezneva N.D.

Otdel po izucheniiu bolezni Al'tsgeĭmera i assotsiirovannykh s neĭ rasstroĭstv Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

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References:

  1. Voronina T.A., Ostrovskaya R.U. Otchet ob eksperimental'nom izuchenii neiropsikhotropnoi aktivnosti atsetil-L-karnitina. NII farmakologii RAMN. M 2000.
  2. Amenta F., Ferrante F., Lucreziotti R. et al. Reduced lipofuscin accumulation in senescent rat brain by long-term acetyl-L-carnitine treatment. Arch Gerontol Geriatr 1989; 9: 147-153.
  3. Angelucci L., Ramacci M.T., Taglialatela G. et al. Nerve growth factor binding in aged rat central nervous system: effect of acetyl-L-carnitine. J Neurosci Res 1988; 20: 491-496.
  4. Bagetta V., Barone I., Ghiglieri V. Acetyl-l-Carnitine selectively prevents post-ischemic LTP via a possible action on mitochondrial energy metabolism. Neuropharmacology 2008; 55: 2: 223-229.
  5. Bianchetti A., Rozzini R., Trabucchi M. Effects of acetyl-L-carnitine in Alzheimer's disease patients unresponsive to acetylcholinesterase inhibitors. Curr Med Res Opin 2003; 19: 4: 350-353.
  6. Bremer J. Carnitine-metabolism and functions. Physiol Rev 1983; 63: 1420-1480.
  7. Brooks J.O. 3rd, Yesavage J.A., Carta A., Bravi D. Acetyl-L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach. Int Psychoger 1998; 10: 193-203.
  8. Calvani M., Arrigoni-Martelli E. Attenuation by acetyl-L-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion. Int J Tissue React 1999; 21: 1-6.
  9. Castorina M., Ambrosini A.M., Pacific L. et al. Age-dependent loss of NMDA receptors in hippocampus, striatum, and frontal cortex of the rat: prevention by acetyl-L-carnitine. Neurochem Res 1994; 19: 795-798.
  10. Epis R., Marcello E., Gardoni F. et al. Modulatory effect of acetyl-l-carnitine on amyloid precursor protein metabolism in hippocampal neurons. Eur J Pharmacol 2008; 597: Issues 1-3: 51-56.
  11. Hagen T.M., Moreau R., Suh J.H., Visioli F. Mitochondrial decay in the aging rat heart. Ann NY Acad Sci 2002; 959: 491-507.
  12. Harsing L.G.Jr., Sershen H., Toth E. et al. Acetyl-L-carnitine releases dopamine in rat corpus striatum: an in vivo microdialysis study. Eur J Pharmacol 1992; 218: 117-121.
  13. Imperato A., Ramacci M.T., Angelucci L. Acetyl-Lcarnitine enhances acetylcholine release in the striatum and hippocampus of awake freely moving rats. Neurosci Lett 1989; 107: 251-255.
  14. Soczynska J.K., Kennedy S.H., Chow C.S.M. Expert Opin Investig Drugs 2008; 17: 6: 827-843.
  15. Montgomery S.A., Thal L.J., Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int Clin Psychopharmacol 2003; 18: 61-71.
  16. Pascale A., Milano S., Corsico N. et al. Protein kinase C activation and anti-amnesic effect of acetyl-L-carnitine: in vitro and in vivo studies. Eur J Pharmacol 1994; 65: 1-7.
  17. Pettegrew J.W., Klunk W.E., Panchalingam K. et al. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease. Neurobiol Aging 1995; 16: 1-4.
  18. Pettegrew J.W., Levine J., McClure R.J. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000; 5: 616-632.
  19. Piovesan P., Pacifici L., Taglialatela G. et al. Acetyl-L-carnitine treatment increases choline acetyltransferase activity and NGF levels in the CNS of adult rats following total fimbria-fornix transection. Brain Res 1994; 633: 77-82.
  20. Sano M., Bell K., Cote L. et al. Double-blind parallel design pilot study of acetyl levocarnitine in patients with Alzheimer's Disease. Arch Neurol 1992; 49: 1137-1141.
  21. Taglialatela G., Caprioli A., Giuliani A. et al. Spatial memory and NGF levels in aged rats: natural variability and effects of acetyl-L-carnitine treatment. Exp Gerontol 1996; 31: 577-587.
  22. Tempesta E., Janiri L., Pirrongelli C. Stereospecific effects of acetylcarnitine on the spontaneous activity of brainstem neurones and their responses to acetylcholine and serotonin. Neuropharmacology 1985; 24: 43-50.
  23. Thal L.J., Carta A., Clarke W.R. et al. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's Disease. Neurology 1996; 47: 705-711.
  24. Toth E., Harsing L.G., Sershen H. et al. Effect of acetyl-L-carnitine on extracellular amino acid levels in vivo in rat brain regions. Neurochem Res 1993; 18: 573-578.
  25. White H.L., Scates P.W. Acetyl-L-carnitine as a precursor of acetylcholine. Neurochem Res 1990; 15: 597-601.
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