The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
Phones:
+7 (495) 482-4118
+7 (495) 482-4329
  • Toll-free number for subscriptions:
    +8 800 250-18-12
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Bogolepova A.N.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia;
Pirogov Russian National Research Medical University, Moscow, Russia

Burd S.G.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia;
Pirogov Russian National Research Medical University, Moscow, Russia

Lebedeva A.V.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia;
Pirogov Russian National Research Medical University, Moscow, Russia

Rubleva Yu.V.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia

Kovalenko E.A.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia;
Pirogov Russian National Research Medical University, Moscow, Russia

Makhnovich E.V.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia;
Pirogov Russian National Research Medical University, Moscow, Russia

Osinovskaya N.A.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia

Pantina N.V.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia

Kovaleva I.I.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia

Bokitko T.A.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia

Alexeeva G.A.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia

Myoclonus in Alzheimer’s disease

Authors:

Bogolepova A.N., Burd S.G., Lebedeva A.V., Rubleva Yu.V., Kovalenko E.A., Makhnovich E.V., Osinovskaya N.A., Pantina N.V., Kovaleva I.I., Bokitko T.A., Alexeeva G.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2026;126(4‑2): 63‑69

DOI: 10.17116/jnevro202612604263

Read: 500 times

Contact the author
Table of contents

MYOCLONUS IN ALZHEIMER’S DISEASE
MYOCLONUS IN ALZHEIMER’S DISEASE

To cite this article:

Bogolepova AN, Burd SG, Lebedeva AV, et al. Myoclonus in Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2026;126(4‑2):63‑69. (In Russ.)
https://doi.org/10.17116/jnevro202612604263

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Coca­rnit in complex therapy of diabetic peri­pheral poly­neuropathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7):73-81
Features of facial expressions in patients with cognitive impairment due to Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7):104-109
Diagnosis of Alzheimer’s disease using biological markers in corticobasal syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):133-139
Characteristics of the functional state of the masticatory muscles in patients with hemi­facial microsomy at the stages of complex treatment. Stomatology. 2025;(5):29-36
Amyloidogenesis and neurotrophic dysfunction in age-related macu­lar dege­neration in correlation with Alzheimer’s disease. Russian Journal of Archive of Pathology. 2025;(6):61-68
Age-related pathomorphological changes in the brain of non-human primates. Mole­cular Gene­tics, Microbiology and Viro­logy. 2025;(4-2):143-149
Epileptic seizures in patients with Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(11):36-43
Electromyographic evaluation of the dyna­mic electroneurostimulation effe­ctiveness in skeletal class III patient reha­bilitation after orthognathic surgery. Stomatology. 2025;(6):43-48
A new look at blood biomarkers in Alzheimer’s patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(12):7-13
Neurogenesis in neurodegeneration: multifactorial regu­lation, mechanisms of impairment, and therapeutic stra­tegies. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(12):14-21
Abstract:

Neurodegenerative diseases are often presented with myoclonus, sudden, short-term, involuntary muscle contractions («flinching»). According to the literature, myoclonus in Alzheimer’s disease (AD) can occur up to 40—50% in cases of disease with early onset and in atypical forms. Importantly, epileptic myoclonus may indicate a risk of seizures with loss of consciousness, convulsions, and epileptiform activity, which may lead to more rapid progression of cognitive deficits. Diagnosis of myoclonus is essential for timely treatment and improving the quality of life of AD patients. The paper describes the main features of myoclonus in AD, the possibility of using additional examination methods, in particular video-electroencephalographic (video-EEG) monitoring for differential diagnosis and etiology clarification, and also presents a clinical case of a patient with AD and epileptic and non-epileptic myoclonus.

Keywords:

neurodegenerative disease
Alzheimer’s disease
myoclonus
video EEG monitoring
electromyography
somatosensory evoked potentials
epileptiform activity

Authors:

Bogolepova A.N.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia;
Pirogov Russian National Research Medical University, Moscow, Russia

Burd S.G.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia;
Pirogov Russian National Research Medical University, Moscow, Russia

Lebedeva A.V.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia;
Pirogov Russian National Research Medical University, Moscow, Russia

Rubleva Yu.V.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia

Kovalenko E.A.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia;
Pirogov Russian National Research Medical University, Moscow, Russia

Makhnovich E.V.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia;
Pirogov Russian National Research Medical University, Moscow, Russia

Osinovskaya N.A.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia

Pantina N.V.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia

Kovaleva I.I.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia

Bokitko T.A.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia

Alexeeva G.A.

Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia, Moscow, Russia

Received:

20.01.2026

Accepted:

22.01.2026

Close metadata

References:

  1. Caviness JN. Myoclonus and neurodegenerative disease-what’s in a name? Parkinsonism Relat Disord. 2003;9(4):185-192.  https://doi.org/10.1016/s1353-8020(02)00054-8
  2. Thompson PD, Day BL, Rothwell JC, et al. The myoclonus in corticobasal degeneration. Evidence for two forms of cortical reflex myoclonus. Brain.1994;117(5):1197-1207. https://doi.org/10.1093/brain/117.5.1197
  3. Lu CS, Ikeda A, Terada K, et al. Electrophysiological studies of early stage corticobasal degeneration. Mov Disord. 1998;13(1):140-146.  https://doi.org/10.1002/mds.870130126
  4. Wenning GK, Shlomo YB, Magalhães M, et al. Clinical features and natural history of multiple system atrophy. An analysis of 100 cases. Brain. 1994;117(4):835-845.  https://doi.org/10.1093/brain/117.4.835
  5. Wenning GK, Tison F, Shlomo YB, et al. Multiple system atrophy: a review of 203 pathologically proven cases. Mov Disord. 1997;12(2):133-147.  https://doi.org/10.1002/mds.870120203
  6. Salazar G, Valls-Solé J, Martí MJ, et al. Postural and action myoclonus in patients with parkinsonian type multiple system atrophy. Mov Disord. 2000;15(1):77-83.  https://doi.org/10.1002/1531-8257(200001)15:1<77::aid-mds1013>3.0.co;2-n
  7. Caviness JN, Kurth M. Cortical myoclonus in Huntington’s disease associated with an enlarged somatosensory. Mov Disord. 1997;12:1046-1051. https://doi.org/10.1002/mds.870120633
  8. Thompson PD, Bhatia KP, Brown P, et al. Cortical myoclonus in Huntington’s disease. Mov Disord. 1994;9(6):633-641.  https://doi.org/10.1002/mds.870090609
  9. Caviness JN, Adler CH, Caselli RJ , et al. Electrophysiology of the myoclonus in dementia with Lewy bodies. Neurology. 2003;60(3):523-524.  https://doi.org/10.1212/wnl.60.3.523
  10. Bobylova MIu, Dunaevskaia GN. Myoclonus in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2012;112(9):77-81. (In Russ.).
  11. Vossel KA, Tartaglia MC, Nygaard HB, et al. Epileptic activity in Alzheimer’s disease: causes and clinical relevance. Lancet Neurol. 2017;6(4):311-322.  https://doi.org/10.1016/S1474-4422(17)30044-3
  12. Beagle AJ, Darwish SM, Ranasinghe KG, et al. Relative Incidence of Seizures and Myoclonus in Alzheimer’s Disease, Dementia with Lewy Bodies, and Frontotemporal Dementia. J Alzheimers Dis. 2017;60(1):211-223.  https://doi.org/10.3233/JAD-170031
  13. Ugawa Y, Kohara N, Hirasawa H, et al. Myoclonus in Alzheimer’s disease. J Neurol. 1987;235(2):90-94.  https://doi.org/10.1007/BF00718016
  14. Samson WN, Duijn CM, Hop WC, et al. Clinical features and mortality in patients with early-onset Alzheimer’s disease. Eur Neurol. 1996;36(2):103-106.  https://doi.org/10.1159/000117218
  15. Ayodele T, Rogaeva E, Kurup JT, et al. Early-onset Alzheimer’s disease: what is missing in research? Curr Neurol Neurosci Rep 2021;21(2):4.  https://doi.org/10.1007/s11910-020-01090-y
  16. Larner AJ. Presenilin-1 mutation Alzheimer’s disease: a genetic epilepsy syndrome? Epilepsy Behav. 2011;21(1):20-22.  https://doi.org/10.1016/j.yebeh.2011.03.022
  17. Alladi S, Xuereb J, Bak T, et al. Focal cortical presentations of Alzheimer’s disease. Brain. 2007;130(10):2636-2645. https://doi.org/10.1093/brain/awm213
  18. Lott IT, Doran E, Nguyen VQ, et al. Down Syndrome and Dementia: Seizures and Cognitive Decline. J Alzheimers Dis. 2012;29(1):177-185.  https://doi.org/10.3233/JAD-2012-111613
  19. Aller-Alvarez JS, Menéndez-González M, Ribacoba-Montero R, et al. Myoclonic epilepsy in Down syndrome and Alzheimer disease. Neurologia. 2017;32(2):69-73.  https://doi.org/10.1016/j.nrl.2014.12.008
  20. Chen JY, Stern Y, Sano M, et al. Cumulative risks of developing extrapyramidal signs, psychosis, or myoclonus in the course of Alzheimer’s disease. Arch Neurol. 1991;48(11):1141-1143. https://doi.org/10.1001/archneur.1991.00530230049020
  21. Asadollahi M, Atazadeh M, Noroozian M. Seizure in Alzheimer’s Disease: An Underestimated Phenomenon. Am J Alzheimers Dis Other Demen. 2019;34(2):81-88.  https://doi.org/10.1177/1533317518813551
  22. Pascarella A, Cianci V, Manzo L, et al. De novo myoclonic status epilepticus in Alzheimer disease. Seizure. 2022;97:35-36.  https://doi.org/10.1016/j.seizure.2022.03.005
  23. Wilkins DE, Hallett M, Erba G, et al. Primary generalised epileptic myoclonus: a frequent manifestation of minipolymyoclonus of central origin. J Neurol Neurosurg Psychiatry. 1985;48(6):506-516.  https://doi.org/10.1136/jnnp.48.6.506
  24. Risse SC, Lampe TH, Bird TD, et al. Myoclonus, seizures, and paratonia in Alzheimer disease. Alzheimer Dis Assoc Disord. 1990;4(4):217-225.  https://doi.org/10.1097/00002093-199040400-00003
  25. Bougea A, Gerakoulis S, Anagnostou E, et al. Donepezil-induced myoclonus in a patient with Alzheimer disease. Ann Pharmacother. 2014;48(12):1659-1661. https://doi.org/10.1177/1060028014550334
  26. Papageorgiou SG, Kontaxis T, Antelli A, et al. Exacerbation of myoclonus by memantine in a patient with Alzheimer disease. Journal of Clinical Psychopharmacology. Lippincott, Williams & Wilkins. 2007;27(4):407-408.  https://doi.org/10.1097/01.jcp.0000264995.31771.05
  27. Wilkins DE, Hallett M, Berardelli A, et al. Physiologic analysis of the myoclonus of Alzheimer’s disease. Neurology. 1984;34(7):898-903.  https://doi.org/10.1212/wnl.34.7.898
  28. Caviness JN. Treatment of Myoclonus. Neurotherapeutics. 2014;11(1):188-200.  https://doi.org/10.1007/s13311-013-0216-3
  29. Caviness JN. Parkinsonism & related disorders. Myoclonus. Parkinsonism Relat Disord. 2007;13(3):375-384.  https://doi.org/10.1016/S1353-8020(08)70033-6
  30. Zutt R, Elting JW, Tijssen MJ. Tremor and myoclonus. Handb Clin Neurol. 2019;161:149-165.  https://doi.org/10.1016/B978-0-444-64142-7.00046-1
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.