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Chan M.D.

Pirogov Russian National Research Medical University

Yasamanova A.N.

Pirogov Russian National Research Medical University

Avakyan G.G.

Pirogov Russian National Research Medical University

Nikonova A.A.

Pirogov Russian National Research Medical University

Kamchatnov P.R.

Pirogov Russian National Research Medical University

The multidirectional effects of thrombin and the possibility of their control in neurology

Authors:

Chan M.D., Yasamanova A.N., Avakyan G.G., Nikonova A.A., Kamchatnov P.R.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(3‑2): 42‑48

DOI: 10.17116/jnevro202412403242

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To cite this article:

Chan MD, Yasamanova AN, Avakyan GG, Nikonova AA, Kamchatnov PR. The multidirectional effects of thrombin and the possibility of their control in neurology. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(3‑2):42‑48. (In Russ.)
https://doi.org/10.17116/jnevro202412403242

Подписка 2025 (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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The review presents the main physiological functions of thrombin. The procoagulant and anticoagulant activities of the key serine protease are discussed in both physiological and pathological conditions of hemostasis. The involvement of thrombin in atherogenesis, as well as its role as a mediator of vascular dysfunction and inflammation in both the peripheral and central nervous system, is highlighted. A pronounced imbalance between the pro- and anticoagulant systems leads to an increase in thrombin formation and creates conditions for the development of thrombosis. Tests that allow direct or indirect assessment of thrombin’s functional activity are presented. The potential applications of direct thrombin inhibitors and direct blockers of thrombin PAR receptors in vascular neurology are also considered.

Keywords:

thrombin
ischemic stroke
hemostasis
platelets
anticoagulant
direct thrombin inhibitors
vorapaxar

Authors:

Chan M.D.

Pirogov Russian National Research Medical University

Yasamanova A.N.

Pirogov Russian National Research Medical University

Avakyan G.G.

Pirogov Russian National Research Medical University

Nikonova A.A.

Pirogov Russian National Research Medical University

Kamchatnov P.R.

Pirogov Russian National Research Medical University

Received:

20.12.2023

Accepted:

29.12.2023

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  47. Receivd 20.12.2023 

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