Long-term neurological outcomes in premature children with excitotoxic brain damage

Savchenko O.A.; Pavlinova E.B.

doi:https://doi.org/10.17116/jnevro202212209237

Savchenko O.A.

Omsk State Medical University

Pavlinova E.B.

Omsk State Medical University

Long-term neurological outcomes in premature children with excitotoxic brain damage

Authors:

Savchenko O.A., Pavlinova E.B.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(9‑2): 37‑41

DOI: 10.17116/jnevro202212209237

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To cite this article:

Savchenko OA, Pavlinova EB. Long-term neurological outcomes in premature children with excitotoxic brain damage. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(9‑2):37‑41. (In Russ.)
https://doi.org/10.17116/jnevro202212209237

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

Использование инфографики авторами научных работ

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OBJECTIVE

To establish the prognostic significance of a biomarker of excitotoxic brain damage (antibodies to the NR2 subunit of the N-methyl-D-aspartate (NMDA) glutamate receptor) as a predictor of damage to the central nervous system (CNS) in preterm infants.

MATERIAL AND METHODS

24 newborns with a gestational age of 24—33 weeks were examined with the determination of the level of antibodies to the NR2 subunit of the NMDA glutamate receptor on the 21st day of life.

RESULTS

In the course of the study, it was found that the level of antibodies to the NR2 subunit of the NMDA glutamate receptor on the 21st day of life, in combination with the level of cord blood lactate and the resistance of cerebral vessels on the 1st day of life, can be predictors of CNS damage in a premature baby at the age of 1 month of corrected age. Predictors of an unfavorable neurological outcome at the age of 1 year of corrected age in a premature baby with perinatal CNS damage are the level of cord blood lactate and antibodies to the NR2 subunit of the NMDA glutamate receptor, determined on the 21st day of life in a newborn.

CONCLUSION

The biomarker of excitotoxic brain damage can be a predictor of long-term neurological outcome and determine the amount, type and duration of neuroprotective care for premature infants.

Keywords:

prematurity

excitotoxicity

glutamatergic receptors

disease prognosis

antihypoxic therapy

Cytoflavin

Authors:

Savchenko O.A.

Omsk State Medical University

Pavlinova E.B.

Omsk State Medical University

Received:

16.03.2022

Accepted:

30.06.2022

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References:

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