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Koltsova E.A.

Pirogov Russian National Research Medical University

Petrova E.A.

Russian State Social University

Borshch Y.V.

Pirogov Russian National Research Medical University

An overview of risk factors for stroke

Authors:

Koltsova E.A., Petrova E.A., Borshch Y.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(12‑2): 12‑19

DOI: 10.17116/jnevro202212212212

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Table of contents

AN OVERVIEW OF RISK FACTORS FOR STROKE
AN OVERVIEW OF RISK FACTORS FOR STROKE

To cite this article:

Koltsova EA, Petrova EA, Borshch YV. An overview of risk factors for stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(12‑2):12‑19. (In Russ.)
https://doi.org/10.17116/jnevro202212212212

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Abstract:

Stroke is a heterogeneous syndrome, and the definition of risk factors, treatment and prevention tactics depends on the specific pathogenesis of the disease. Risk factors for ischemic and hemorrhagic stroke are similar, but at the same time there are significant differences. The concept of stroke triggers is discussed separately. In addition, a deep understanding of the pathogenetic mechanisms and the development of new strategies for therapy and prevention require an understanding of the genetic mechanisms of stroke risk. Genetic factors may be more modifiable than previously thought. To reduce the burden of stroke in the population, timely identification and management of modifiable risk factors is essential.

Keywords:

stroke
ischemic stroke
hemorrhagic stroke
risk factors
stroke triggers
stroke prevention

Authors:

Koltsova E.A.

Pirogov Russian National Research Medical University

Petrova E.A.

Russian State Social University

Borshch Y.V.

Pirogov Russian National Research Medical University

Received:

04.11.2022

Accepted:

07.11.2022

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References:

  1. Johnston SC, Mendis S, Mathers CD. Global variation in stroke burden and mortality: estimates from monitoring, surveillance, and modelling. Lancet Neurol. 2009;8:345-354.  https://doi.org/10.1016/S1474-4422(09)70023-7
  2. Viswanathan A, Rocca WA, Tzourio C. Vascular risk factors and dementia: how to move forward? Neurology. 2009;72:368-374.  https://doi.org/10.1212/01.wnl.0000341271.90478.8e
  3. Ovbiagele B, Goldstein LB, Higashida RT, et al. American Heart Association Advocacy Coordinating Committee and Stroke Council. Forecasting the future of stroke in the United States: a policy statement from the American Heart Association and American Stroke Association. Stroke. 2013;44:2361-2375. https://doi.org/10.1161/STR.0b013e31829734f2
  4. Adams HP, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24:35-41. 
  5. Chien KL, Su TC, Hsu HC, et al. Constructing the prediction model for the risk of stroke in a Chinese population: report from a cohort study in Taiwan. Stroke. 2010;41:1858-1864. https://doi.org/10.1161/STROKEAHA.110.586222
  6. Skvortsova VI, Koltsova EA, Botsina AYu. Genetics of ischemic stroke. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. Stroke. 2001;4:10-18. (In Russ.).
  7. Elkind MS. Why now? Moving from stroke risk factors to stroke triggers. Curr Opin Neurol. 2007;20:51-57.  https://doi.org/10.1097/WCO.0b013e328012da75
  8. Skvortsova VI, Koltsova EA, Kimelfeld EI. Ischemic stroke in young patients. Journal Neurology and Psychiatry S.S. Korsakov. Stroke. 2009;109(10):3-14. (In Russ.).
  9. Skvortsova VI, Koltsova EA, Kimelfeld EI. Comparative analysis of risk factors and pathogenetic variants of ischemic stroke in young and old age. Kursk Scientific and Practical Bulletin «Man and his health». 2012;3:81-87. (In Russ.).
  10. D’Agostino RB, Wolf PA, Belanger AJ, Kannel WB. Stroke risk profile: adjustment for antihypertensive medication. The Framingham Study. Stroke. 1994;25:40-43. 
  11. Den Ruijter HM, Peters SA, Anderson TJ, et al. Common carotid intima-media thickness measurements in cardiovascular risk prediction: a meta-analysis. JAMA. 2012;308:796-803.  https://doi.org/10.1001/jama.2012.9630.
  12. O’Donnell MJ, Xavier D, Liu L, et al. INTERSTROKE investigators. Risk factors for ischaemic and intracerebralhaemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet. 2010;376:112-123.  https://doi.org/10.1016/S0140-6736(10)60834-3
  13. George MG, Tong X, Kuklina EV, Labarthe DR. Trends in stroke hospitalizations and associated risk factors among children and young adults, 1995—2008. Ann Neurol. 2011;70:713-721.  https://doi.org/10.1002/ana.22539
  14. van Asch CJ, Luitse MJ, Rinkel GJ, et al. Incidence, case fatality, and functional outcome of intracerebralhaemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis. Lancet Neurol. 2010;9:167-176.  https://doi.org/10.1016/S1474-4422(09)70340-0
  15. Kapral MK, Fang J, Hill MD, et al. Investigators of the Registry of the Canadian Stroke Network. Sex differences in stroke care and outcomes: results from the Registry of the Canadian Stroke Network. Stroke. 2005;36:809-814.  https://doi.org/10.1161/01.STR.0000157662.09551.e5
  16. Morgenstern LB, Smith MA, Lisabeth LD, et al. Excess stroke in Mexican Americans compared with non-Hispanic Whites: the Brain Attack Surveillance in Corpus Christi Project. Am J Epidemiol. 2004;160:376-383.  https://doi.org/10.1093/aje/kwh225
  17. Kleindorfer D, Broderick J, Khoury J, et al. The unchanging incidence and case-fatality of stroke in the 1990s: a population-based study. Stroke. 2006;37:2473-2478. https://doi.org/10.1161/01.STR.0000242766.65550.92
  18. Zhang Y, Galloway JM, Welty TK, et al. Incidence and risk factors for stroke in American Indians: the Strong Heart Study. Circulation. 2008;118:1577-1584. https://doi.org/10.1161/CIRCULATIONAHA.108.772285
  19. Kimball MM, Neal D, Waters MF, Hoh BL. Race and income disparity in ischemic stroke care: nationwide inpatient sample database, 2002 to 2008. J Stroke Cerebrovasc Dis. 2014;23:17-24.  https://doi.org/10.1016/j.jstrokecerebrovasdis.2012.06.004
  20. Schulz UG, Flossmann E, Rothwell PM. Heritability of ischemic stroke in relation to age, vascular risk factors, and subtypes of incident stroke in population-based studies. Stroke. 2004;35:819-824.  https://doi.org/10.1161/01.STR.0000121646.23955.0f
  21. Touzé E, Rothwell PM. Sex differences in heritability of ischemic stroke: a systematic review and meta-analysis. Stroke. 2008;39:16-23.  https://doi.org/10.1161/STROKEAHA.107.484618
  22. Roger VL, Go AS, Lloyd-Jones DM, et al. American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Executive summary: heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation. 2012;125:188-197.  https://doi.org/10.1161/CIR.0b013e3182456d46
  23. Lewington S, Clarke R, Qizilbash N, et al. Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360:1903-1913. https://doi.org/10.1016/s0140-6736(02)11911-8
  24. Vasan RS, Beiser A, Seshadri S, et al. Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study. JAMA. 2002;287:1003-1010. https://doi.org/10.1001/jama.287.8.1003
  25. Kotovskaya YuV, Tkacheva ON, Ostapenko VS, Luzina AV. Arterialnaya hypertension in the very elderly: the significance of frailty. RMZh. 2017;25:1829-1832.
  26. Suchy-Dicey AM, Wallace ER, Mitchell SV, et al. Blood pressure variability and the risk of all-cause mortality, incident myocardial infarction, and incident stroke in the cardiovascular health study. Am J Hypertens. 2013;26:1210-1217. https://doi.org/10.1093/ajh/hpt092
  27. Banerjee C, Moon YP, Paik MC, et al. Duration of diabetes and risk of ischemic stroke: the Northern Manhattan Study. Stroke. 2012;43:1212-1217. https://doi.org/10.1161/STROKEAHA.111.641381
  28. Kissela BM, Khoury J, Kleindorfer D, et al. Epidemiology of ischemic stroke in patients with diabetes: the greater Cincinnati/Northern Kentucky Stroke Study. Diabetes Care. 2005;28:355-359.  https://doi.org/10.2337/diacare.28.2.355
  29. Gaede P, Lund-Andersen H, Parving HH, Pedersen O. Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med. 2008;358:580-591.  https://doi.org/10.1056/NEJMoa0706245
  30. Yiin GS, Howard DP, Paul NL, Li L, Luengo-Fernandez R, Bull LM, Welch SJ, Gutnikov SA, Mehta Z, Rothwell PM; Oxford Vascular Study. Age-specific incidence, outcome, cost, and projected future burden of atrial fibrillation-related embolic vascular events: a population-based study. Circulation. 2014;130:1236-1244. https://doi.org/10.1161/CIRCULATIONAHA.114.010942
  31. Brambatti M, Connolly SJ, Gold MR, et al.; ASSERT Investigators. Temporal relationship between subclinical atrial fibrillation and embolic events. Circulation. 2014;129:2094-2099. https://doi.org/10.1161/CIRCULATIONAHA.113.007825
  32. Kamel H, Elkind MS, Bhave PD, Navi BB, Okin PM, Iadecola C, Devereux RB, Fink ME. Paroxysmal supraventricular tachycardia and the risk of ischemic stroke. Stroke. 2013;44:1550-1554. https://doi.org/10.1161/STROKEAHA.113.001118
  33. Disertori M, Quintarelli S, Grasso M, et al. Autosomal recessive atrial dilated cardiomyopathy with standstill evolution associated with mutation of Natriuretic Peptide Precursor A. CircCardiovasc Genet. 2013;6:27-636.  https://doi.org/10.1161/CIRCGENETICS.112.963520
  34. O’Neal WT, Kamel H, Kleindorfer D, et al. Premature atrial contractions on the screening electrocardiogram and risk of ischemic stroke: the Reasons for Geographic and Racial Differences in Stroke study. Neuroepidemiology. 2016;47:53-58.  https://doi.org/10.1159/000448619
  35. Kamel H, Okin PM, Elkind MS, Iadecola C. Atrial fibrillation and mechanisms of stroke: time for a new model. Stroke. 2016;47:895-900.  https://doi.org/10.1161/STROKEAHA.115.012004
  36. Kurth T, Everett BM, Buring JE, et al. Lipid levels and the risk of ischemic stroke in women. Neurology. 2007;68:556-562.  https://doi.org/10.1212/01.wnl.0000254472.41810.0d
  37. Hackam DG, Austin PC, Huang A, et al. Statins and intracerebral hemorrhage: a retrospective cohort study. Arch Neurol. 2012;69:39-45.  https://doi.org/10.1001/archneurol.2011.228
  38. Lauer A, Greenberg SM, Gurol ME. Statins in intracerebralhemorrhage. Curr Atheroscler Rep. 2015;17:46.  https://doi.org/10.1007/s11883-015-0526-5
  39. Zhou ML, Zhu L, Wang J, et al. The inflammation in the gut after experimental subarachnoid hemorrhage. J Surg Res. 2007;137:103-108.  https://doi.org/10.1016/j.jss.2006.06.023
  40. Li XY, Cai XL, Bian PD, Hu LR. High salt intake and stroke: meta-analysis of the epidemiologic evidence. CNS Neurosci Ther. 2012;18:691-701.  https://doi.org/10.1111/j.1755-5949.2012.00355.x
  41. Lu Y, Hajifathalian K, Ezzati M, et al. Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects). Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1.8 million participants. Lancet. 2014;383:970-983.  https://doi.org/10.1016/S0140-6736(13)61836-X
  42. Koren-Morag N, Goldbourt U, Tanne D. Relation between the metabolic syndrome and ischemic stroke or transient ischemic attack: a prospective cohort study in patients with atherosclerotic cardiovascular disease. Stroke. 2005;36:1366-1371. https://doi.org/10.1161/01.STR.0000169945.75911.33
  43. Rantakömi SH, Laukkanen JA, Sivenius J, et al. Alcohol consumption and the risk of stroke among hypertensive and overweight men. J Neurol. 2013;260:534-539.  https://doi.org/10.1007/s00415-012-6672-6
  44. Esse K, Fossati-Bellani M, Traylor A, Martin-Schild S. Epidemic of illicit drug use, mechanisms of action/addiction and stroke as a health hazard. Brain Behav. 2011;1:44-54.  https://doi.org/10.1002/brb3.7
  45. Malek AM, Cushman M, Lackland DT, et al. Secondhand smoke exposure and stroke: the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. Am J Prev Med. 2015;49:89-97.  https://doi.org/10.1016/j.amepre.2015.04.014
  46. Kaptoge S, Di Angelantonio E, Lowe G, et al. Emerging Risk Factors Collaboration. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet. 2010;375:132-140.  https://doi.org/10.1016/S0140-6736(09)61717-7
  47. Zhou Y, Han W, Gong D, et al. Hs-CRP in stroke: a meta-analysis. Clin Chim Acta. 2016;453:21-27.  https://doi.org/10.1016/j.cca.2015.11.027
  48. Zacho J, Tybjaerg-Hansen A, Jensen JS, et al. Genetically elevated C-reactive protein and ischemic vascular disease. N Engl J Med. 2008;359:1897-1908. https://doi.org/10.1056/NEJMoa0707402
  49. Eisenhardt SU, Habersberger J, Murphy A, et al. Dissociation of pentameric to monomeric C-reactive protein on activated platelets localizes inflammation to atherosclerotic plaques. Circ Res. 2009;105:128-137.  https://doi.org/10.1161/CIRCRESAHA.108.190611
  50. Libby P. Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol. 2012;32:2045-2051. https://doi.org/10.1161/ATVBAHA.108.179705
  51. Elkind MS, Ramakrishnan P, Moon YP, et al. Infectious burden and risk of stroke: the northern Manhattan study. Arch Neurol. 2010;67:33-38.  https://doi.org/10.1001/archneurol.2009.271
  52. Wright CB, Gardener H, Dong C, et al. Infectious burden and cognitive decline in the Northern Manhattan Study. J Am Geriatr Soc. 2015;63:1540-1545. https://doi.org/10.1111/jgs.13557
  53. Gutierrez J, Goldman J, Dwork AJ, et al. Brain arterial remodeling contribution to nonembolic brain infarcts in patients with HIV. Neurology. 2015;85:1139-1145. https://doi.org/10.1212/WNL.0000000000001976
  54. Sabin CA, Ryom L, De Wit S, et al. D:A:D Study Group. Associations between immune depression and cardiovascular events in HIV infection. AIDS. 2013;27:2735-2748. https://doi.org/10.1097/01.aids.0000432457.91228.f3
  55. Elkind MS, Carty CL, O’Meara ES, et al. Hospitalization for infection and risk of acute ischemic stroke: the Cardiovascular Health Study. Stroke. 2011;42:1851-1856. https://doi.org/10.1161/STROKEAHA.110.608588
  56. Walkey AJ, Hammill BG, Curtis LH, Benjamin EJ. Long-term outcomes following development of new-onset atrial fibrillation during sepsis. Chest. 2014;146:1187-1195. https://doi.org/10.1378/chest.14-0003
  57. Corrales-Medina VF, Alvarez KN, Weissfeld LA, et al. Association between hospitalization for pneumonia and subsequent risk of cardiovascular disease. JAMA. 2015;313:264-274.  https://doi.org/10.1001/jama.2014.18229
  58. Tonne C, Halonen JI, Beevers SD, et al. Long-term traffic air and noise pollution in relation to mortality and hospital readmission among myocardial infarction survivors. Int J Hyg Environ Health. 2016;219:72-78.  https://doi.org/10.1016/j.ijheh.2015.09.003
  59. Sørensen M, Lühdorf P, Ketzel M, et al. Combined effects of road traffic noise and ambient air pollution in relation to risk for stroke? Environ Res. 2014;133:49-55.  https://doi.org/10.1016/j.envres.2014.05.011
  60. Scheers H, Jacobs L, Casas L, et al. Long- term exposure to particulate matter air pollution is a risk factor for stroke: meta-analytical evidence. Stroke. 2015;46:3058-3066. https://doi.org/10.1161/STROKEAHA.115.009913
  61. Khasanova LT, Stakhovskaya LV, Koltsova EA, Shamalov NA. Genetic characteristics of stroke. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2019;119(12-2):65-72. (In Russ.). https://doi.org/10.17116/jnevro201911912265
  62. Skvortsova VI, Koltsova EA, Kimelfeld EI, et al. Analysis of the contribution of — 5t/c polymorphism in the GP1BA gene to the development of ischemic stroke in young patients. Nevrologiya, Neiropsikhiatriya, Psihosomatika. 2012;4:39-44. (In Russ.).
  63. Kimelfeld EI, Kol’tsova EA, Petrova EA, et al. The association of hemostasis system genes with the development of ischemic stroke in patients under the age of 50 years. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2018;118(9-2):14-21. (In Russ.). https://doi.org/10.17116/jnevro201811809214
  64. Falcone GJ, Malik R, Dichgans M, Rosand J. Current concepts and clinical applications of stroke genetics. Lancet Neurol. 2014;13:405-418.  https://doi.org/10.1016/S1474-4422(14)70029-8
  65. Bevan S, Traylor M, Adib-Samii P, et al. Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genome wide associations. Stroke. 2012;43:3161-3167. https://doi.org/10.1161/STROKEAHA.112.665760
  66. Williams FM, Carter AM, Hysi PG, et al.; EuroCLOT Investigators; Wellcome Trust Case Control Consortium 2; MOnica Risk, Genetics, Archiving and Monograph; MetaStroke; International Stroke Genetics Consortium. Ischemic stroke is associated with the ABO locus: the EuroCLOTstudy. Ann Neurol. 2013;73:16-31.  https://doi.org/10.1002/ana.23838
  67. Malik R, Traylor M, Pulit SL, et al.; ISGC Analysis Group; METASTROKE collaboration; Wellcome Trust Case Control Consortium 2 (WTCCC2); NINDS Stroke Genetics Network (SiGN). Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration. Neurology. 2016;86:1217-1226. https://doi.org/https://doi.org/10.1212/WNL.0000000000002528
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