Intracranial hypertension in hemorrhagic stroke: a single-center retrospective study

Avidzba A.R.; Nikonov A.M.; Lychakov A.V.; Saskin V.A.; Kirov M.Yu.

doi:https://doi.org/10.17116/anaesthesiology202406123

Avidzba A.R.

Northern State Medical University

ORCID: 0000-0002-2397-353X

Nikonov A.M.

Northern State Medical University

ORCID: 0000-0002-4660-6767

Lychakov A.V.

Northern State Medical University

ORCID: 0009-0002-3732-4052

Saskin V.A.

Northern State Medical University

ORCID: 0009-0006-8326-5021

Kirov M.Yu.

Northern State Medical University

SPIN RSCI: 2025-8162
Scopus AuthorID: 7004841942
ORCID: 0000-0002-4375-3374

Intracranial hypertension in hemorrhagic stroke: a single-center retrospective study

Authors:

Avidzba A.R., Nikonov A.M., Lychakov A.V., Saskin V.A., Kirov M.Yu.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2024;(6): 23‑29

DOI: 10.17116/anaesthesiology202406123

Read: 2577 times

To cite this article:

Avidzba AR, Nikonov AM, Lychakov AV, Saskin VA, Kirov MYu. Intracranial hypertension in hemorrhagic stroke: a single-center retrospective study. Russian Journal of Anesthesiology and Reanimatology. 2024;(6):23‑29. (In Russ., In Engl.)
https://doi.org/10.17116/anaesthesiology202406123

Использование инфографики авторами научных работ

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BACKGROUND

Hemorrhagic stroke (HS) is a polyetiological disease including all forms of non-traumatic intracranial hemorrhage, accompanied by high disability and mortality. More than 67% of spontaneous intracerebral hemorrhage cases are complicated by intracranial hypertension (ICH), and ICH occurs in 71% of patients with aneurysmal subarachnoid hemorrhage.

OBJECTIVE

To evaluate the incidence of ICH, mortality, functional outcomes, and predictors of treatment outcomes in patients with severe HS.

MATERIAL AND METHODS

A single-center retrospective study was conducted at the regional stroke center in Arkhangelsk. We analyzed the incidence of ICH and outcomes in patients with HS. Predictors of mortality and functional recovery of patients after HS were estimated using logistic and linear regression models.

RESULTS

The study enrolled 74 patients with HS and implanted probe for intracranial pressure (ICP) monitoring. ICH developed in 45 (60 %) cases. Mortality rate was 39.2% (n=29). ICH was an independent predictor of mortality in HS (adjusted OR 4.4, 95% CI 1.4—16.4 (p=0.04). Maximum in-hospital ICP was also an independent predictor of mortality (adjusted OR 1.08, 95% CI 1.0—1.1, p=0.002). Incidence of ICH was not associated with modified Rankin Scale score (mRS) at discharge (B=0.3 (β=0.08), 95% CI –0.49 to 1.04 (p=0.48), but maximum ICH was independently associated with higher mRS score (B=0.03 (β=0.36), 95% CI 0.02 to 0.05 (p<0.001).

CONCLUSION

ICH is a common phenomenon in HS patients with high mortality rate. ICH is a predictor of mortality in patients who underwent ICP monitoring. At the same time, functional outcome was determined by maximum in-hospital ICP, but not ICH per se.

Keywords:

Keyword: intracranial hypertension

aneurysmal subarachnoid hemorrhage

spontaneous intracerebral hemorrhage

mortality

functional recovery

Authors:

Avidzba A.R.

Northern State Medical University

ORCID: 0000-0002-2397-353X

Nikonov A.M.

Northern State Medical University

ORCID: 0000-0002-4660-6767

Lychakov A.V.

Northern State Medical University

ORCID: 0009-0002-3732-4052

Saskin V.A.

Northern State Medical University

ORCID: 0009-0006-8326-5021

Kirov M.Yu.

Northern State Medical University

SPIN RSCI: 2025-8162
Scopus AuthorID: 7004841942
ORCID: 0000-0002-4375-3374

Received:

27.07.2024

Accepted:

15.08.2024

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