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Boyko A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Smirnova N.F.

Pirogov Russian National Research Medical University;
Federal Center for Brain and Neurotechnology of the FMBA

Shchukin I.A.

Pirogov Russian National Research Medical University;
Federal Center of Brain and Neurotechnologies of the Federal Medical and Biological Agency of Russia;
Pirogov City Clinical Hospital No. 1

Guseva M.E.

Pirogov Russian National Research Medical University

Volkov A.I.

Federal Center of Brain and Neurotechnology of Federal Medical-Biological Agency of Russia

Ofatumumab — a new drug for the treatment of multiple sclerosis

Authors:

Boyko A.N., Smirnova N.F., Shchukin I.A., Guseva M.E., Volkov A.I.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(7‑2): 37‑43

DOI: 10.17116/jnevro202112107237

Read: 9266 times

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Table of contents

OFATUMUMAB — A NEW DRUG FOR THE TREATMENT OF MULTIPLE SCLEROSIS
OFATUMUMAB — A NEW DRUG FOR THE TREATMENT OF MULTIPLE SCLEROSIS

To cite this article:

Boyko AN, Smirnova NF, Shchukin IA, Guseva ME, Volkov AI. Ofatumumab — a new drug for the treatment of multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(7‑2):37‑43. (In Russ.)
https://doi.org/10.17116/jnevro202112107237

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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Abstract:

Recently anti-B-cell therapy has been increasingly integrated into the treatment of multiple sclerosis (MS). This review is devoted to ofatumumab, a new drug of this line. Ofatumumab, an all-human monoclonal antibody used to treat chronic leukemia, binds to a different region than the binding site of other CD20 antibodies, including both a small and large loop in the CD20 receptor structure. This monoclonal antibody provides favorable results for MS by reducing the frequency of exacerbations and the risk of disability progression, significantly more pronounced when compared with teriflunomide. The drug can be used in patients with active relapsing MS and SPMS with exacerbations, with the ineffectiveness of first-line drugs as one of the options for second-line therapy, in patients with highly active MS, especially with a high risk of PML (transfer from natalizumab), as well as if there are difficulties in organizing intravenous courses in day hospitals (produced as outpatient injections).

Keywords:

multiple sclerosis
treatment
anti-B-cell therapy
ofatamumab

Authors:

Boyko A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Smirnova N.F.

Pirogov Russian National Research Medical University;
Federal Center for Brain and Neurotechnology of the FMBA

Shchukin I.A.

Pirogov Russian National Research Medical University;
Federal Center of Brain and Neurotechnologies of the Federal Medical and Biological Agency of Russia;
Pirogov City Clinical Hospital No. 1

Guseva M.E.

Pirogov Russian National Research Medical University

Volkov A.I.

Federal Center of Brain and Neurotechnology of Federal Medical-Biological Agency of Russia

Received:

20.05.2021

Accepted:

26.05.2021

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References:

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