Efficacy and safety of ethylmethylhydroxypyridine succinate in patients with ischemic stroke

Zhuravleva M.V.; Shchukin I.A.; Fidler M.S.; Prokofiev A.B.; Serebrova S.Yu.; Vasyukova N.S.; Demchenkova E.Yu.; Arkhipov V.V.

doi:https://doi.org/10.17116/jnevro202012012260

Zhuravleva M.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
Scientific Centre of Medical Application Expertise of the Ministry of the Healthcare of the Russian Federation

ORCID: 0000-0002-9198-8661

Shchukin I.A.

Pirogov Russian National Research Medical University;
Federal Center of Brain and Neurotechnologies of the Federal Medical and Biological Agency of Russia;
Pirogov City Clinical Hospital No. 1

ORCID: 0000-0002-6308-9706

Fidler M.S.

Pirogov Russian National Research Medical University;
Pirogov City Clinical Hospital No. 1

ORCID: 0000-0001-6464-521X

Prokofiev A.B.

Scientific Center for Examination of Medical Devices;
Sechenov First Moscow State Medical University

Serebrova S.Yu.

Scientific Center for Examination of Medical Devices;
Sechenov First Moscow State Medical University

Vasyukova N.S.

Federal Scientific Center-all-Russian Research Skriabin and Kovalenko Institute of Experimental Veterinary Medicine the Russian Academy of Sciences

Demchenkova E.Yu.

Scientific Center for Examination of Medical Devices

Arkhipov V.V.

Scientific Center for Examination of Medical Devices

Efficacy and safety of ethylmethylhydroxypyridine succinate in patients with ischemic stroke

Authors:

Zhuravleva M.V., Shchukin I.A., Fidler M.S., Prokofiev A.B., Serebrova S.Yu., Vasyukova N.S., Demchenkova E.Yu., Arkhipov V.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(12‑2): 60‑66

DOI: 10.17116/jnevro202012012260

Read: 2508 times

To cite this article:

Zhuravleva MV, Shchukin IA, Fidler MS, et al. . Efficacy and safety of ethylmethylhydroxypyridine succinate in patients with ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(12‑2):60‑66. (In Russ., In Engl.)
https://doi.org/10.17116/jnevro202012012260

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

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Abstract:

Stroke is still the most significant problem of the modern medicine and the leading cause of mortality and morbidity. There is the great experience of neuroprotection in patients with stroke in the Russian Federation. In clinical practice it’s important to follow conditions, where neuroprotection will have maximum safety and effectiveness. The clinical trials of ethylmethylhydroxypyridine succinate (mexidol) in patients with acute ischemic stroke are described in the present review. Early management (in the first 6 hours) with mexidol significantly improve recovery dynamic and stroke outcome. Therapy with mexidol increases neurological recovery, improves vital activity and quality of life of patients with stroke. Furthermore, mexidol demonstrates high safety profile.

Keywords:

ischemic stroke

thrombolytic therapy

clinical trial

disability

antioxidant system

ethylmethylhydroxypyridine succinate

Mexidol

Authors:

Zhuravleva M.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
Scientific Centre of Medical Application Expertise of the Ministry of the Healthcare of the Russian Federation

ORCID: 0000-0002-9198-8661

Shchukin I.A.

Pirogov Russian National Research Medical University;
Federal Center of Brain and Neurotechnologies of the Federal Medical and Biological Agency of Russia;
Pirogov City Clinical Hospital No. 1

ORCID: 0000-0002-6308-9706

Fidler M.S.

Pirogov Russian National Research Medical University;
Pirogov City Clinical Hospital No. 1

ORCID: 0000-0001-6464-521X

Prokofiev A.B.

Scientific Center for Examination of Medical Devices;
Sechenov First Moscow State Medical University

Serebrova S.Yu.

Scientific Center for Examination of Medical Devices;
Sechenov First Moscow State Medical University

Vasyukova N.S.

Federal Scientific Center-all-Russian Research Skriabin and Kovalenko Institute of Experimental Veterinary Medicine the Russian Academy of Sciences

Demchenkova E.Yu.

Scientific Center for Examination of Medical Devices

Arkhipov V.V.

Scientific Center for Examination of Medical Devices

Received:

23.09.2020

Accepted:

29.10.2020

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References:

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