Objective. To analyze epidemiological data and predict the morbidity and mortality of stroke for a 5-year period in different age groups. Material and methods. The study of indicators of morbidity and mortality of stroke was conducted on the basis of data on the population aged 25 years and older from the territorial population register for 2009—2016 and covered 8 study areas. A total of 25.504 cases of primary stroke were analyzed in four age groups: young age, middle age, old age, oldest age. The prognosis of indicators of morbidity and mortality was made using the ARIMA (autoregressive integrated moving average) method. Results and conclusion. The study revealed positive dynamics for 2009—2016 to reduce the incidence of stroke in middle age and old age. The morbidity in the group of young people in 2016 was lower than in 2009, though the difference was not significant. In the group of oldest age, there was a tendency to increase the incidence rate since 2012, the growth rate reached 10% per year. Prediction of stroke incidence for 5 years was impossible in all age groups due to the lack of significant autocorrelations. Positive dynamics of reduction of mortality of stroke was observed among middle, old and oldest age. The highest rate of decline in mortality was observed in middle aged and old people amounting to about 30% in 2012. Among the oldest age, the dynamics of the reduction of mortality rate was less pronounced. Among young people, the death rate has not changed since 2009 by 2016 and amounted to 0.05 per 1000 people. Prediction of the mortality rate for middle age assumes a decrease in mortality by 2019 inclusive with further stabilization of the indicator until 2021. The prognosis of mortality in old age suggests a gradual slight increase (about 1.5%) over the entire forecast horizon. Taking into account the progress in the 8-year decline by 81%, the projected growth does not change the burden of stroke in the old age.