Sleep and cognitive impairment in neurodegenerative diseases

Iakovleva O.V.; Poluéktov M.G.; Liashenko E.A.; Levin O.S.

doi:https://doi.org/10.17116/jnevro201911904289

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Abstract:

Sleep and wakefulness disorders are commonly seen in patients with Parkinson’s disease, Lewy body dementia and Alzheimer’s disease. Sleep provides a lot of functions which sustain normal condition of the brain and sleep disturbances can be one of the factors contributing to the development of neurodegenerative diseases. Sleep and wakefulness disorders can worsen the course of the neurodegenerative process and lead to an increase of symptoms, including cognitive dysfunction. In this review, the relationship between sleep and wakefulness disorders and cognitive impairment as well as clinical forms of sleep and wakefulness disorders and treatment methods in such patients are discussed.

Keywords:

sleep and wakefulness disorders

insomnia

excessive daytime sleepiness

REM sleep behavior disorder

obstructive sleep apnea syndrome

restless legs syndrome

Parkinson’s disease

Alzheimer’s disease

Lewy body dementia

melatonin

Authors:

Iakovleva O.V.

Russian Medical Academy of Continuous Professional Education, Centre of Extrapyramidal Disorders, Moscow, Russsia

Poluéktov M.G.

Kurs somnologii pri kafedre nervnykh bolezneĭ fakul'teta poslevuzovskogo professional'nogo obrazovaniia Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Liashenko E.A.

Kafedra nevrologii Rossiĭskoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Moskva;
Tsentr kstrapiramidnykh zabolevaniĭ, Moskva

Levin O.S.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia

SPIN RSCI: 5342-1373
Scopus AuthorID: 57147160800
ORCID: 0000-0003-3872-5923

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