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Mamalyga M.L.

Kafedra anatomii i fiziologii cheloveka i zhivotnykh Moskovskogo pedagogicheskogo gosudarstvennogo universiteta, Moskva

Mamalyga L.M.

Institute of Biology and Chemistry of the Moscow Pedagogical State University, Moscow

The effect of status epilepticus on autonomic regulation of the heart and its functional capabilities in different postictal periods

Authors:

Mamalyga M.L., Mamalyga L.M.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(11‑2): 48‑54

DOI: 10.17116/jnevro201911911248

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THE EFFECT OF STATUS EPILEPTICUS ON AUTONOMIC REGULATION OF THE HEART AND ITS FUNCTIONAL CAPABILITIES IN DIFFERENT POSTICTAL PERIODS
THE EFFECT OF STATUS EPILEPTICUS ON AUTONOMIC REGULATION OF THE HEART AND ITS FUNCTIONAL CAPABILITIES IN DIFFERENT POSTICTAL PERIODS

To cite this article:

Mamalyga ML, Mamalyga LM. The effect of status epilepticus on autonomic regulation of the heart and its functional capabilities in different postictal periods. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(11‑2):48‑54. (In Russ.)
https://doi.org/10.17116/jnevro201911911248

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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Abstract:

Objective. To study the postictal changes in the autonomic regulation of the heart rhythm and its functional capabilities in different periods after epistatus and to assess the risk of life-threatening arrhythmias. Material and methods. The study was conducted on Wistar rats after epileptic status (ES). Telemonitoring of EEG and ECG was performed in the online mode using the system of the company «ADInstruments». Functional stress test with dobutamine was used. Results. ES leads to a long-lasting disturbance of autonomic regulation (AR) of the heart and reduces its functional capabilities. The heart’s AR balance is shifted towards sympathetic tonus 5 days after ES. This increases the predictors of life-threatening arrhythmias. The decrease in SWD activity increases the activity of parasympathetic tonus 10 days after ES. However, this is due to the tension of regulation mechanisms and the risk of life-threatening arrhythmias. Conclusion. The high degree of seizure activity of the brain in the ES predetermines prolonged postictal disorders of the AR heart, which reduce its functional capabilities and increase the risk of life-threatening arrhythmias.

Keywords:

status epilepticus
ECG
functional capabilities of the heart
heart rate variability
arrhythmia

Authors:

Mamalyga M.L.

Kafedra anatomii i fiziologii cheloveka i zhivotnykh Moskovskogo pedagogicheskogo gosudarstvennogo universiteta, Moskva

Mamalyga L.M.

Institute of Biology and Chemistry of the Moscow Pedagogical State University, Moscow

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