Paroxysmal atrial fibrillation in patients with sinoatrial blockade undergoing permanent pacing and metabolic therapy

Smirnov V.N.; Staroverov I.N.; Gromyko G.A.; Smirnova M.P.

doi:https://doi.org/10.17116/kardio202518061634

Smirnov V.N.

Yaroslavl State Medical University

ORCID: 0000-0002-3314-0486

Staroverov I.N.

Yaroslavl State Medical University;
Yaroslavl Regional Clinical Hospital

ORCID: 0000-0001-9855-9475

Gromyko G.A.

Yaroslavl State Medical University;
Yaroslavl Regional Clinical Hospital

ORCID: 0000-0002-7942-9795

Smirnova M.P.

Yaroslavl State Medical University;
Yaroslavl Regional Clinical Hospital

ORCID: 0000-0002-8988-998X

Paroxysmal atrial fibrillation in patients with sinoatrial blockade undergoing permanent pacing and metabolic therapy

Authors:

Smirnov V.N., Staroverov I.N., Gromyko G.A., Smirnova M.P.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2025;18(6): 634‑639

DOI: 10.17116/kardio202518061634

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To cite this article:

Smirnov VN, Staroverov IN, Gromyko GA, Smirnova MP. Paroxysmal atrial fibrillation in patients with sinoatrial blockade undergoing permanent pacing and metabolic therapy. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;18(6):634‑639. (In Russ.)
https://doi.org/10.17116/kardio202518061634

Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)

Использование инфографики авторами научных работ

OBJECTIVE

To study the effect of trimetazidine dihydrochloride on the total number of atrial fibrillation paroxysms in patients with sinus node weakness syndrome and permanent two-chamber pacing.

MATERIAL AND METHODS

The study included 138 patients with various types of sinoatrial blockades and two-chamber pacing systems. Two groups of patients were formed: 1 — patients receiving metabolic therapy; 2 — patients not receiving metabolic therapy. The effect of trimetazidine dihydrochloride on the total number of atrial fibrillation paroxysms was evaluated in 3 and 12 months after implantation of two-chamber pacing system. All patients of both groups received standard therapy for concomitant diseases.

RESULTS

Trimetazidine dihydrochloride in patients with various types of sinoatrial blockades after implantation of two-chamber pacing system reduces the total number of paroxysms of atrial fibrillation. There was a significant (p<0.05) decrease in the number of paroxysms of atrial fibrillation under metabolic therapy in 3 and 12 months after pacing system implantation.

CONCLUSION. A

Dministration of trimethazidine dihydrochloride as a part of complex therapy reduces the total number of paroxysms of atrial fibrillation in patients with sinus node weakness syndrome after implantation of two-chamber pacing system.

Keywords:

bradycardia

arrhythmia

pacing

exchange therapy

sinus node

Authors:

Smirnov V.N.

Yaroslavl State Medical University

ORCID: 0000-0002-3314-0486

Staroverov I.N.

Yaroslavl State Medical University;
Yaroslavl Regional Clinical Hospital

ORCID: 0000-0001-9855-9475

Gromyko G.A.

Yaroslavl State Medical University;
Yaroslavl Regional Clinical Hospital

ORCID: 0000-0002-7942-9795

Smirnova M.P.

Yaroslavl State Medical University;
Yaroslavl Regional Clinical Hospital

ORCID: 0000-0002-8988-998X

Received:

14.01.2025

Accepted:

10.02.2025

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