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Boĭko O.V.

Moskovskiĭ gorodskoĭ tsentr rasseiannogo skleroza na baze Gorodskoĭ klinicheskoĭ bol'nitsy #11

Khoroshylova I.I.

OOO «Neuroclinica», Moscow, Russia

Petrov S.V.

North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia, Elizabethan hospital, Saint-Petersburg, Russia

Mel'nikov M.V.

Kafedra obshcheĭ khirurgii Sankt-Peterburgskoĭ gosudarstvennoĭ meditsinskoĭ akademii im. I.I. Mechnikova

Boĭko A.N.

KGBUZ "Krasnoiarskiĭ kraevoĭ Tsentr po profilaktike i bor'be so SPID i infektsionnymi zabolevaniiami"

Changes in the quality of life in patients with multiple sclerosis treated with ocrelizumab

Authors:

Boĭko O.V., Khoroshylova I.I., Petrov S.V., Mel'nikov M.V., Boĭko A.N.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(10‑2): 120‑127

DOI: 10.17116/jnevro2019119102120

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Table of contents

CHANGES IN THE QUALITY OF LIFE IN PATIENTS WITH MULTIPLE SCLEROSIS TREATED WITH OCRELIZUMAB
CHANGES IN THE QUALITY OF LIFE IN PATIENTS WITH MULTIPLE SCLEROSIS TREATED WITH OCRELIZUMAB

To cite this article:

Boĭko OV, Khoroshylova II, Petrov SV, Mel'nikov MV, Boĭko AN. Changes in the quality of life in patients with multiple sclerosis treated with ocrelizumab. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(10‑2):120‑127. (In Russ.)
https://doi.org/10.17116/jnevro2019119102120

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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Abstract:

Objective. To study the quality of life (QoL) in patients with multiple sclerosis (MS) treated with ocrelizumab for at least 12 months. Material and methods. Thirty-eight patients were observed, including 13 with primary progressive MS (PPMS), 15 with highly active relapsing-remitting MS (HAMS) and 10 with secondary progressive MS (SPMS) with relapses. QoL was studied using unspecific SF-36 and MS-specific MusiQoL questionnaires. Depression and fatigue were assessed with the Beck Depression Scale (BDS) and the Modified Fatigue Impact Scale (MFIS). Results and conclusion. Basic characteristics of QoL indexes of the patients were similar to those previously reported for these MS variants. After 6 and 12 months, a significant increase in the indexes of the majority of SF-36 and MusiQoL scales was identified that shows a significant improvement in both physical and psychological domains of QoL. The significant and rapid decrease in depression severity after 6-month treatment with ocrelizumab may at least in part be associated with improvement of indexes of vitality, general health, social relations and the total QoL score.

Keywords:

multiple sclerosis
B-cells
ocrelizumab
quality of life
depression

Authors:

Boĭko O.V.

Moskovskiĭ gorodskoĭ tsentr rasseiannogo skleroza na baze Gorodskoĭ klinicheskoĭ bol'nitsy #11

Khoroshylova I.I.

OOO «Neuroclinica», Moscow, Russia

Petrov S.V.

North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia, Elizabethan hospital, Saint-Petersburg, Russia

Mel'nikov M.V.

Kafedra obshcheĭ khirurgii Sankt-Peterburgskoĭ gosudarstvennoĭ meditsinskoĭ akademii im. I.I. Mechnikova

Boĭko A.N.

KGBUZ "Krasnoiarskiĭ kraevoĭ Tsentr po profilaktike i bor'be so SPID i infektsionnymi zabolevaniiami"

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