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Zakharova M.N.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Lysogorskaya E.V.

Neurology Research Center, Moscow, Russia

Trushnikova T.N.

GBOU VPO "Permskaia gosudarstvennaia meditsinskaia akademiia im. akad. E.A. Vagnera", Perm'

Zhelnin A.V.

GBOU VPO «Permskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. E.A. Vagnera» Minzdrava RF;
GBUZ PK «Permskaja kraevaja klinicheskaja bolnitsa», Perm

The case-report of progressive multifocal leukoencephalopathy in a patient with multiple sclerosis treated with natalizumab

Authors:

Zakharova M.N., Lysogorskaya E.V., Trushnikova T.N., Zhelnin A.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(8‑2): 107‑109

DOI: 10.17116/jnevro2018118082107

Read: 667 times

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Table of contents

THE CASE-REPORT OF PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY IN A PATIENT WITH MULTIPLE SCLEROSIS TREATED WITH NATALIZUMAB
THE CASE-REPORT OF PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY IN A PATIENT WITH MULTIPLE SCLEROSIS TREATED WITH NATALIZUMAB

To cite this article:

Zakharova MN, Lysogorskaya EV, Trushnikova TN, Zhelnin AV. The case-report of progressive multifocal leukoencephalopathy in a patient with multiple sclerosis treated with natalizumab. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(8‑2):107‑109. (In Russ.)
https://doi.org/10.17116/jnevro2018118082107

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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Abstract:

The article describes the first case of progressive multifocal leukoencephalopathy in a patient with multiple sclerosis, developed during treatment with natalizumab. The causes, possibly, influencing the outcome of the disease, are analyzed.

Keywords:

multiple sclerosis
progressive multifocal leukoencephalopathy
natalizumab
glucocorticosteroids

Authors:

Zakharova M.N.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Lysogorskaya E.V.

Neurology Research Center, Moscow, Russia

Trushnikova T.N.

GBOU VPO "Permskaia gosudarstvennaia meditsinskaia akademiia im. akad. E.A. Vagnera", Perm'

Zhelnin A.V.

GBOU VPO «Permskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. E.A. Vagnera» Minzdrava RF;
GBUZ PK «Permskaja kraevaja klinicheskaja bolnitsa», Perm

Close metadata

References:

  1. Carrillo-Infante C, Richman S, Yu B, Wenten M, Roberson A, Philip J, McIninch J, Richert N, Licata S, Ho P-R, Bloomgren G. Functional and survival outcomes of asymptomatic progressive multifocal leukoencephalopathy in natalizumab-treated multiple sclerosis patients: 2015 update. ECTRIMS Online Library. 2016;EP1528.
  2. Ho P-R, Koendgen H, Campbell N, Haddock B, Richman S, Chang J. Risk of natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: a retrospective analysis of data from four clinical studies. Lancet Neurol. 2017;16(11):925-933. https://doi.org/10.1016/S1474-4422(17)30282-X
  3. Physician Information and Management Guidelines for Multiple Sclerosis patients on TYSABRI Therapy. European Medicines Agency. 2016. http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/referrals/Tysabri/human_referral_prac_000049.jsp&mid=WC0b01ac05805c516f
  4. Settipane GA, Pudupakkam RK, McGowan JH. Corticosteroid effect on immunoglobulins. J Allergy Clin Immunol. 1978;62(3):162-166.
  5. Butler WT, Rossen RD. Effects of corticosteroids on immunity in man. I. Decreased serum IgG concentration caused by 3 or 5 days of high doses of methylprednisolone. J Clin Invest. 1973;52(10):2629-2640.
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