The state of microcirculation and platelet hemostasis in patients with ischemic stroke after systemic thrombolytic therapy

Anisimova A.V.; Galkin S.S.; Krupatkin A.I.; Sidorov V.V.; Gunchenko A.S.

doi:https://doi.org/10.17116/jnevro20181183239-42

Anisimova A.V.

GBOU VPO "Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova", Moskva

Galkin S.S.

GBOU VPO "Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova", Moskva

Krupatkin A.I.

N.N. Priorov National Research Center of Traumatology and Orthopedics, Ministry of Health of the Russia, Moscow, Russia

Sidorov V.V.

Pirogov Russian National Research Medical University, Moscow

Gunchenko A.S.

Pirogov Russian National Research Medical University, Moscow, Russia

The state of microcirculation and platelet hemostasis in patients with ischemic stroke after systemic thrombolytic therapy

Authors:

Anisimova A.V., Galkin S.S., Krupatkin A.I., Sidorov V.V., Gunchenko A.S.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(3‑2): 39‑42

DOI: 10.17116/jnevro20181183239-42

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To cite this article:

Anisimova AV, Galkin SS, Krupatkin AI, Sidorov VV, Gunchenko AS. The state of microcirculation and platelet hemostasis in patients with ischemic stroke after systemic thrombolytic therapy. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(3‑2):39‑42. (In Russ.)
https://doi.org/10.17116/jnevro20181183239-42

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

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Abstract:

Objective. The state of microcirculation and platelet hemostasis in patients with ischemic stroke after systemic thrombolytic therapy. Material and methods. Forty-two patients after systemic thrombolytic therapy (TLT) (mean age 64.26 [60.58; 68.06]) and 47 patients without TLT (54.52 [47.48; 60.83]) were studied. The study of platelet hemostasis was conducted with the determination of platelet aggregation (AT) on adrenaline, ADP, ristomycin, spontaneous aggregation on days 1, 7 and 14. Studies of the state of microcirculation of cerebral vessels were carried out using the laser Doppler flowmetry (LDF). Results and conclusion. Characteristics of changes in induced AT and parameters of the microcirculation system in patients after systemic TLT at 1, 7 and 14 days in comparison with the indices of patients without TLT were revealed that allowed to expand the understanding of pathological mechanisms of the microcirculatory bed, their connection with violations of central hemodynamics and to obtain additional markers of disease course and prognosis.

Keywords:

ischemic stroke

systemic thrombolytic therapy

hemostasis

microcirculation system

laser Doppler flowmetry

prognosis

Authors:

Anisimova A.V.

GBOU VPO "Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova", Moskva

Galkin S.S.

GBOU VPO "Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova", Moskva

Krupatkin A.I.

N.N. Priorov National Research Center of Traumatology and Orthopedics, Ministry of Health of the Russia, Moscow, Russia

Sidorov V.V.

Pirogov Russian National Research Medical University, Moscow

Gunchenko A.S.

Pirogov Russian National Research Medical University, Moscow, Russia

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References:

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