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Stakhovskaya L.V.

Pirogov Russian National Research Medical University, Moscow, Russia

Tyutyumova E.A.

Pirogov Russian National Research Medical University

Fedin A.I.

Kafedra nevrologii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta

Modern approaches to neuroprotective treatment of ischemic stroke

Authors:

Stakhovskaya L.V., Tyutyumova E.A., Fedin A.I.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(8‑2): 75‑80

DOI: 10.17116/jnevro20171178275-80

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To cite this article:

Stakhovskaya LV, Tyutyumova EA, Fedin AI. Modern approaches to neuroprotective treatment of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(8‑2):75‑80. (In Russ.)
https://doi.org/10.17116/jnevro20171178275-80

Подписка 2025 (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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The authors present the results of domestic clinical trials on the efficacy and safety of mexidol in patients with cerebrovascular disorders including ischemic stroke (IS). The use of mexidol is associated with complete and rapid regression of the focal neurological deficit. Mexidol is well tolerated with no significant side-effects. The drug is recommended for enteral and parenteral administration in patients with IS.

Keywords:

ischemic stroke
treatment
mexidol

Authors:

Stakhovskaya L.V.

Pirogov Russian National Research Medical University, Moscow, Russia

Tyutyumova E.A.

Pirogov Russian National Research Medical University

Fedin A.I.

Kafedra nevrologii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta

List of references:

  1. Ivanova GE, Shklovskii VM, Petrova EA. The principles of early rehabilitation of stroke patients. Kachestvo zhizni. Meditsina. 2006;2(13):62-70. (In Russ.).
  2. Skvortsova VI. Snizhenie zabolevaemosti, smertnosti i invalidnosti ot insul’tov v Rossiiskoi Federatsii. M.: Litterra; 2008. (In Russ.).
  3. Fedin AI, Tyutyumova EA, Badalyan KR. Ischemic cascade in the acute period of the stroke and methods of its correction. Farmateka. 2017;9:99-104. (In Russ.).
  4. Khasanova DR, Gavrilov IA, Prokof’eva IuV, Kamalov IR. The introduction of the multilevel system of medical care for stroke patients in the Tatarstan Republic. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2014;114:8(2):74-79. (In Russ.).
  5. Fedin AI. Klinicheskie aspekty patogeneticheskoi terapii ishemii golovnogo mozga. Minimizatsiya negativnogo prognoza. M.: OOO «AST»; 2016. (In Russ.).
  6. Voronina TA. The pioneer of antioxidant neuroprotection. 20 years in clinical practice. RMJ. 2016;24(7):434-438. (In Russ.).
  7. Shulkin AV. Mexidol influence on the development of the phenomen of neurons excitotoxicity in vitro. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2012;112(2):35-39. (In Russ.).
  8. Skvortsova VI, Stakhovskaya LV, Nartsyssov YaR, Bodykhov MK, Kichuck IV, Gudkova YuV, Soldatenkova TD, Kondrasheva TT, Kalinina EV, Novichkova MD, Kerbikov OB. The randomized double-blind placebo-controlled study of efficacy and safety of mexidol in the complex therapy of ischemic stroke in the acute period. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2006;106(18):47-54. (In Russ.).
  9. Novikova LB, Sharafutdinova LR, Sharapova KM. The use of mexidol in acute period of ischemic stroke. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2013;113:9:83-85. (In Russ.).
  10. Shchepankevich LA, Nicolaev YuA, Dolgova NA, Chipova DT. Optimization of hypolipidemic therapy in patients with ischemic stroke and diabetes mellitus. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2016;116:2:42-45. (In Russ.).
  11. Odinak MM, Ianishevskiĭ SN, Tsygan NV, Golokhvastov SIu, Vozniuk IA, Trufanov AG. The use of succinates for the correction of metabolic disorders in the penumbra in patients with stroke. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2013;113:12(2):12-17. (In Russ.).
  12. Chefranova ZhYu, Makotrova TA, Udachin VA, Koledintseva EV. Efficacy of mexidol in the combination with thrombolytic therapy in patients with ischemic stroke. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2012;112:4:49-52. (In Russ.).
  13. Stakhovskaya LV, Shamalov NA, Khasanova DR, Melnikova EV, Agafiina AS, Golikov KV, Bogdanov EI, Yakupova AA, Roshkovskaya LV, Lukinykh LV, Lokshtanova TM, Poverennova IE, Shepankevich LA. Results of a randomized double blind multicenter placebo-controlled, in parallel groups trial of the efficacy and safety of prolonged sequential therapy with mexidol in the acute and early recovery stages of hemispheric ischemic stroke (EPICA). Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2017;117:3(2):55-65. (In Russ.). https://doi.org/10.17116/jnevro20171173255-65

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