Diagnostic value of immunoglobulin free light chains at the debut of multiple sclerosis

Nazarov V.D.; Makshakov G.S.; Mazing A.V.; Surkova E.A.; Krasnov V.S.; Shumilina M.V.; Totolian N.A.; Evdoshenko E.P.; Lapin S.V.; Emanuel’ V.L.; Skoromets A.A.

doi:https://doi.org/10.17116/jnevro20171172260-65

Nazarov V.D.

Tsentr rassejannogo skleroza i drugih demielinizirujuschih zabolevaniĭ Gorodskoĭ klinicheskoĭ bolnitsy №31, Sankt-Peterburg

Makshakov G.S.

Tsentr rassejannogo skleroza i drugih demielinizirujuschih zabolevaniĭ Gorodskoĭ klinicheskoĭ bolnitsy №31, Sankt-Peterburg

Mazing A.V.

First Saint-Petersburg Pavlov State Medical University, Saint-Petersburg

Surkova E.A.

GBOU VPO «Pervyj Sankt-Peterburgskij gosudarstvennyj meditsinskij universitet im. akad. I.P. Pavlova» Minzdrava Rossii, Sankt-Peterburg, Rossija

Krasnov V.S.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova, kafedra nevrologii s klinikoĭ;
Federal'nyĭ tsentr serdtsa, krovi i éndokrinologii im. V.A. Almazova, Sankt-Peterburg

Shumilina M.V.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

Scopus AuthorID: 6507018914
ORCID: 0000-0001-7439-2690

Totolian N.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova

Evdoshenko E.P.

Sankt-Peterburgskoe GBUZ "Gorodskaia klinicheskaia bol'nitsa #31", Sankt-Peterburgskiĭ gorodskoĭ Tsentr rasseiannogo skleroza i autoimmunnykh zabolevaniĭ, Sankt-Peterburg

Scopus AuthorID: 51763507000
ORCID: 0000-0002-8006-237X

Lapin S.V.

Pavlov First St. Petersburg State Medical University, Russia, 197022, St. Petersburg, St. Leo Tolstoy 6/8

ORCID: 0000-0002-4998-3699

Emanuel’ V.L.

Federal State Budgetary Educational Institution of Higher Education «Academician I.P. Pavlov First Saint Petersburg State Medical University» of the Ministry of Healthcare of the Russia, Saint Petersburg, Russia

SPIN RSCI: 1177-4802
Scopus AuthorID: 6603693075

Skoromets A.A.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

Diagnostic value of immunoglobulin free light chains at the debut of multiple sclerosis

Authors:

Nazarov V.D., Makshakov G.S., Mazing A.V., Surkova E.A., Krasnov V.S., Shumilina M.V., Totolian N.A., Evdoshenko E.P., Lapin S.V., Emanuel’ V.L., Skoromets A.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(2‑2): 60‑65

DOI: 10.17116/jnevro20171172260-65

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To cite this article:

Nazarov VD, Makshakov GS, Mazing AV, et al. Diagnostic value of immunoglobulin free light chains at the debut of multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(2‑2):60‑65. (In Russ.)
https://doi.org/10.17116/jnevro20171172260-65

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

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Abstract:

Objective. To evaluate the diagnostic value of determination of free immunoglobulin light chains (IgG) in the debut of multiple sclerosis (MS). Material and methods. Data from 226 patients, including 111 patients with clinically isolated syndrome with conversion to multiple sclerosis within the first 2 years of the disease (group 1), 49 patients with clinically isolated syndrome who did not develop multiple sclerosis within the first 2 years of the disease (group 2), 20 patients with other inflammatory diseases of the central nervous system (group 3) were analyzed. The control group consisted of 46 patients with non-inflammatory diseases of the central nervous system. The clonality of immunoglobulins in the CSF, concentration of kappa and lambda free light chains and their ratio were studied. Results. Concentrations of free light chains were significantly higher in the first group in comparison with group 2 and the control group, but didn’t differ from group 3. In group 3, concentrations of free light chains were significantly higher compared to group 2 and controls. In oligoclonal-positive patients with clinically isolated syndrome (groups 1 and 2), concentrations of kappa and lambda free light chains were significantly higher than in oligoclonal-negative patients. The production of free light chains in patients from the first group was considerably higher than in group 2 regardless of the oligoclonal status. The concentration of kappa chains and quotient of kappa free light chains in the CSF had the best diagnostic characteristics. Their use, along with the evaluation of IgG clonality, reduced the risk of false-negative results by 50%. Regardless of other factors, elevated concentrations of kappa chains increase the likelihood of MS diagnosis by 9.718 times. Conclusion. The use of free light chains as a laboratory marker can increase the accuracy of MS diagnosis. These markers can help indirectly assess the risk of transformation of a clinically isolated syndrome into definite multiple sclerosis within the first 2 years of disease.

Keywords:

multiple sclerosis

clinically isolated syndrome

immunoglobulin free light chains

oligoclonal bands

biomarkers

Authors:

Nazarov V.D.

Tsentr rassejannogo skleroza i drugih demielinizirujuschih zabolevaniĭ Gorodskoĭ klinicheskoĭ bolnitsy №31, Sankt-Peterburg

Makshakov G.S.

Tsentr rassejannogo skleroza i drugih demielinizirujuschih zabolevaniĭ Gorodskoĭ klinicheskoĭ bolnitsy №31, Sankt-Peterburg

Mazing A.V.

First Saint-Petersburg Pavlov State Medical University, Saint-Petersburg

Surkova E.A.

GBOU VPO «Pervyj Sankt-Peterburgskij gosudarstvennyj meditsinskij universitet im. akad. I.P. Pavlova» Minzdrava Rossii, Sankt-Peterburg, Rossija

Krasnov V.S.

Shumilina M.V.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

Scopus AuthorID: 6507018914
ORCID: 0000-0001-7439-2690

Totolian N.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova

Evdoshenko E.P.

Sankt-Peterburgskoe GBUZ "Gorodskaia klinicheskaia bol'nitsa #31", Sankt-Peterburgskiĭ gorodskoĭ Tsentr rasseiannogo skleroza i autoimmunnykh zabolevaniĭ, Sankt-Peterburg

Scopus AuthorID: 51763507000
ORCID: 0000-0002-8006-237X

Lapin S.V.

Pavlov First St. Petersburg State Medical University, Russia, 197022, St. Petersburg, St. Leo Tolstoy 6/8

ORCID: 0000-0002-4998-3699

Emanuel’ V.L.

SPIN RSCI: 1177-4802
Scopus AuthorID: 6603693075

Skoromets A.A.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

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