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Stvolinsky S.L.

Neurology Research Center, Moscow, Russia

Fedorova T.N.

FGBU "Nauchnyĭ tsentr nevrologii RAMN", Moskva

Devyatov A.A.

Neurology Research Center, Moscow, Russia;
Federal Research Center for Nutrition, Biotechnology and Food Safety, Moscow, Russia

Medvedev O.S.

Lomonosov Moscow State University, Moscow, Russia

Belousova M.A.

Lomonosov Moscow State University, Moscow, Russia

Ryzhkov I.N.

Federal Research Center for Nutrition, Biotechnology and Food Safety, Moscow, Russia

Tutelyan V.A.

Federal Research Center for Nutrition, Biotechnology and Food Safety, Moscow, Russia

A neuroprotective action of carnosine in conditions of experimental focal cerebral ischemia-reperfusion

Authors:

Stvolinsky S.L., Fedorova T.N., Devyatov A.A., Medvedev O.S., Belousova M.A., Ryzhkov I.N., Tutelyan V.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(12‑2): 60‑64

DOI: 10.17116/jnevro201711712260-64

Read: 5737 times

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Table of contents

A NEUROPROTECTIVE ACTION OF CARNOSINE IN CONDITIONS OF EXPERIMENTAL FOCAL CEREBRAL ISCHEMIA-REPERFUSION
A NEUROPROTECTIVE ACTION OF CARNOSINE IN CONDITIONS OF EXPERIMENTAL FOCAL CEREBRAL ISCHEMIA-REPERFUSION

To cite this article:

Stvolinsky SL, Fedorova TN, Devyatov AA, Medvedev OS, Belousova MA, Ryzhkov IN, Tutelyan VA. A neuroprotective action of carnosine in conditions of experimental focal cerebral ischemia-reperfusion. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(12‑2):60‑64. (In Russ.)
https://doi.org/10.17116/jnevro201711712260-64

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Abstract:

Objective. To assess neuroprotective properties of preventive injections of carnosine in experimental focal cerebral ischemia in rats. Material and methods. A focal ischemia in Wistar rats induced by the 60 min-occlusion of the middle cerebral artery with the following 24h-reperfusion was used. Animals received carnosine mixed with ration in daily dose of 150 mg/kg of body mass during 7 days before surgery. Results and conclusion. Carnosine decreased the size of the lesion by 20%, neurological deficit by 43% with a simultaneous increase in the antioxidant status of blood plasma and brain tissue compared to the animals of the control group. The authors showed for the first time the neuroprotective effect of low dose of carnosine (150 mg/kg of body mass) mixed with ration used in preventive treatment courses in the experimental focal cerebral ischemia-reperfusion model.

Keywords:

brain
focal ischemia
reperfusion
carnosine
neuroprotection

Authors:

Stvolinsky S.L.

Neurology Research Center, Moscow, Russia

Fedorova T.N.

FGBU "Nauchnyĭ tsentr nevrologii RAMN", Moskva

Devyatov A.A.

Neurology Research Center, Moscow, Russia;
Federal Research Center for Nutrition, Biotechnology and Food Safety, Moscow, Russia

Medvedev O.S.

Lomonosov Moscow State University, Moscow, Russia

Belousova M.A.

Lomonosov Moscow State University, Moscow, Russia

Ryzhkov I.N.

Federal Research Center for Nutrition, Biotechnology and Food Safety, Moscow, Russia

Tutelyan V.A.

Federal Research Center for Nutrition, Biotechnology and Food Safety, Moscow, Russia

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