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Kotov A.S.

Moskovskiĭ oblastnoĭ nauchno-issledovatel'skiĭ klinicheskiĭ institut im. M.F. Vladimirskogo

Gushchina E.V.

Vladimirsky Moscow Regional Resaerch Clinical Institute, Moscow, Russia

Matiuk Yu.V.

Vladimirsky Moscow Regional Resaerch Clinical Institute, Moscow, Russia

Borisova M.N.

GBUZ MO «Moskovskiĭ oblastnoĭ nauchno-issledovatelskiĭ klinicheskiĭ institut im. M.F. Vladimirskogo», Moskva

Panteleeva M.V.

GBUZ MO «Moskovskiĭ oblastnoĭ nauchno-issledovatelskiĭ klinicheskiĭ institut im. M.F. Vladimirskogo», Moskva

Shatalin A.V.

GBUZ MO «Moskovskiĭ oblastnoĭ nauchno-issledovatelskiĭ klinicheskiĭ institut im. M.F. Vladimirskogo», Moskva

Leber's hereditary optic neuropathy and epilepsy: a case report

Authors:

Kotov A.S., Gushchina E.V., Matiuk Yu.V., Borisova M.N., Panteleeva M.V., Shatalin A.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(9‑2): 89‑94

DOI: 10.17116/jnevro20161169289-94

Read: 4231 times

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Table of contents

LEBER'S HEREDITARY OPTIC NEUROPATHY AND EPILEPSY: A CASE REPORT
LEBER'S HEREDITARY OPTIC NEUROPATHY AND EPILEPSY: A CASE REPORT

To cite this article:

Kotov AS, Gushchina EV, Matiuk YuV, Borisova MN, Panteleeva MV, Shatalin AV. Leber's hereditary optic neuropathy and epilepsy: a case report. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(9‑2):89‑94. (In Russ.)
https://doi.org/10.17116/jnevro20161169289-94

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Abstract:

A clinical case of a young man with rapid bilateral visual impairment developed 2 months after the onset of generalized convulsive seizures is presented. The replacement of valproate to levetiracetam led to the remission of seizures, but the prognosis for vision remains poor, particularly given the pessimistic results of optical coherence tomography (OCT).

Keywords:

Leber’s hereditary optic neuropathy
epilepsy

Authors:

Kotov A.S.

Moskovskiĭ oblastnoĭ nauchno-issledovatel'skiĭ klinicheskiĭ institut im. M.F. Vladimirskogo

Gushchina E.V.

Vladimirsky Moscow Regional Resaerch Clinical Institute, Moscow, Russia

Matiuk Yu.V.

Vladimirsky Moscow Regional Resaerch Clinical Institute, Moscow, Russia

Borisova M.N.

GBUZ MO «Moskovskiĭ oblastnoĭ nauchno-issledovatelskiĭ klinicheskiĭ institut im. M.F. Vladimirskogo», Moskva

Panteleeva M.V.

GBUZ MO «Moskovskiĭ oblastnoĭ nauchno-issledovatelskiĭ klinicheskiĭ institut im. M.F. Vladimirskogo», Moskva

Shatalin A.V.

GBUZ MO «Moskovskiĭ oblastnoĭ nauchno-issledovatelskiĭ klinicheskiĭ institut im. M.F. Vladimirskogo», Moskva

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References:

  1. Mascialino B, Leinonen M, Meier T. Meta-analysis of the prevalence of Leber hereditary optic neuropathy mtDNA mutations in Europe. Eur J Ophthalmol. 2012;22(3):461-465. doi: 10.5301/ejo.5000055
  2. Dimitriadis K, Leonhardt M, Yu-Wai-Man P, Kirkman MA, Korsten A, De Coo IF, Chinnery PF, Klopstock T. Leber’s hereditary optic neuropathy with late disease onset: clinical and molecular characteristics of 20 patients. Orphanet J Rare Dis. 2014;9:158. doi: 10.1186/s13023-014-0158-9
  3. Carelli V, Valentino M L, Liguori R, Meletti S, Vetrugno R, Provini F, Mancardi GL, Bandini F, Baruzzi A, Montagna P. Leber's hereditary optic neuropathy (LHON/11778) with myoclonus: report of two cases. J Neurol Neurosurg Psychiatry. 2001;71(6):813-816.
  4. Spruijt L, Smeets HJ, Hendrickx A, Bettink-Remeijer MW, Maat-Kievit A, Schoonderwoerd KC, Sluiter W, de Coo IF, Hintzen RQ. A MELAS — associated ND1 mutation causing leber hereditary optic neuropathy and spastic dystonia. Arch Neurol. 2007;64(6):890-893.
  5. Watanabe M, Mita S, Takita T, Goto Y, Uchino M, Imamura S. Leber's hereditary optic neuropathy with dystonia in a Japanese family. J Neurol Sci. 2006;243(1-2):31-34.
  6. Frye RE. Leber's hereditary optic neuropathy mutations associated with infantile-onset myoclonic epilepsy. J Child Neurol. 2011;26(6):782-785. doi: 10.1177/0883073810391531
  7. Niehusmann P, Surges R, von Wrede RD, Elger CE, Wellmer J, Reimann J, Urbach H, Vielhaber S, Bien CG, Kunz WS. Mitochondrial dysfunction due to Leber's hereditary optic neuropathy as a cause of visual loss during assessment for epilepsysurgery. Epilepsy Behav. 2011;20(1):38-43. doi: 10.1016/j.yebeh.2010.11.008
  8. Rinalduzzi S, Cipriani AM, Accornero N. Topiramate and visual loss in a patient carrying a Leber hereditary optic neuropathymutation. Neurol Sci. 2012;33(2):419-421. doi: 10.1007/s10072-011-0755-5
  9. Kotov A.S., Tolstova N.V. K voprosu o K voprosu ob idiopaticheskih generalizovannyh i kriptogennyh fokal'nyh jepilepsijah u podrostkov i molodyh vzroslyh. Nevrologicheskij zhurnal. 2012;1:21-25.
  10. Klopstock T, Yu-Wai-Man P, Dimitriadis K, Rouleau J, Heck S, Bailie M, Atawan A, Chattopadhyay S, Schubert M, Garip A, Kernt M, Petraki D, Rummey C, Leinonen M, Metz G, Griffiths PG, Meier T, Chinnery PF. A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy. Brain. 2011;134(9):2677-2686. doi: 10.1093/brain/awr170
  11. Mashima Y, Kigasawa K, Wakakura M, Oguchi Y. Do idebenone and vitamin therapy shorten the time to achieve visual recovery in Leber hereditary optic neuropathy? J Neuroophthalmol. 2000;20(3):166-170.
  12. Jafarian I, Eskandari MR, Mashayekhi V, Ahadpour M, Hosseini MJ. Toxicity of valproic acid in isolated rat livermitochondria. Toxicol Mech Methods. 2013;23(8):617-623. doi: 10.3109/15376516.2013.821567
  13. Chaudhry N, Patidar Y, Puri V. Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes unveiled byvalproate. J Pediatr Neurosci. 2013;8(2):135-137. doi: 10.4103/1817-1745.117847
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