A review of literature and possible explanations of the phenomenon of clinico-radiological paradox in multiply sclerosis are presented. The phenomenon of so-called clinical and MRI dissociation (clinical and MRI paradox in multiple sclerosis) has been described. These dissociations can be divided into type I with a predominance of focal MRI lesions over clinical data (multi-centric lesions on MRI, EDSS scores <2B) and type II with a prevalence of clinical symptoms over MRI data (single brain lesions, EDSS scores >2B). The explanations of this phenomenon (new diagnostic possibilities, a role of nervous tissue plasticity, the neuropsychological status, coping strategies of people with MS as well as interactions between mental, nervous and immune systems) are presented.