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Smagina I.V.

Otdelenie nevrologii kraevoĭ klinicheskoĭ bolnitsy, Barnaul;
kafedra nervnykh bolezneĭ s kursom nevrologii i refleksoterapii fakulteta povysheniia kvalifikatsii i PPS, Barnaul;
kafedra biokhimii i klinicheskoĭ laboratornoĭ diagnostiki Altaĭskogo gosudarstvennogo meditsinskogo universiteta, Barnaul;
Novosibirskiĭ gosudarstvennyĭ universitet, Novosibirsk

Elchaninova S.A.

Relationship between biochemical parameters of cerebrospinal fluid and the course of multiple sclerosis

Authors:

Smagina I.V., Elchaninova S.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2013;113(10‑2): 43‑46

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To cite this article:

Smagina IV, Elchaninova SA. Relationship between biochemical parameters of cerebrospinal fluid and the course of multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2013;113(10‑2):43‑46.

 
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We examined 60 patients with remitting multiple sclerosis (disability 3,5±1.6 EDSS scores). The relative risk of rapid progression of neurologic impairment was associated with the higher levels of matrix metalloproteinase-2, soluble platelet endothelial cell adhesion molecule-1 (sPECAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in the cerebrospinal fluid. The relative risk of exacerbation of the disease in the next three years was associated with the level of tumor necrosis factor alpha and matrix metalloproteinase-2.

Keywords:

multiple sclerosis
cerebrospinal fluid
matrix metalloproteinase-2
adhesion molecule
tumor necrosis factor alpha

Authors:

Smagina I.V.

Otdelenie nevrologii kraevoĭ klinicheskoĭ bolnitsy, Barnaul;
kafedra nervnykh bolezneĭ s kursom nevrologii i refleksoterapii fakulteta povysheniia kvalifikatsii i PPS, Barnaul;
kafedra biokhimii i klinicheskoĭ laboratornoĭ diagnostiki Altaĭskogo gosudarstvennogo meditsinskogo universiteta, Barnaul;
Novosibirskiĭ gosudarstvennyĭ universitet, Novosibirsk

Elchaninova S.A.

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