Poststroke fatigue

Kutlubaev M.A.; Akhmadeeva L.R.

doi:https://doi.org/

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Abstract:

A study included patients, aged from 30 to 70 years, with a verified diagnosis of compensated diabetes mellitus type 1 or type 2, diabetic polyneuropathy (DPN) or the syndrome of moderate cognitive disorders (MCD). Patients with DPN were stratified into two groups: 30 patients of the main group received the antioxidant drug tiolepta in tablets (600 mg) once a day during 60 days; 30 patients of the control group received only basic (sugar-reducing) therapy. Twenty patients with MCD were treated with the combined nootropic and vasoactive drug vinpotropil in dose 2 capsules, 3 times a day during 2 months in addition to the basic therapy (sugar-reducing, antihypertensive, antiaggregate drugs). To the end of treatment, the severity of DPN was lower in the main group treated with tiolepta that reflected in the normalization of NDS scores in 50% of patients compared to 30% in the controls and in the disappearance of neurological symptoms on the TSS in 30% of patients while these symptoms were present in the control group. The electroneuromyographic study showed the statistically non-significant trend (p>0,05) to the higher velocity of impulse conduction along the sensory and motor nerves as well as higher amplitudes of motor and sensory responses in the main group. To the end of the treatment, positive dynamics in the number of complaints and neurological status was found in patients with MCD. The neuropsychological study revealed the significant (p<0,05) improvement on the MMSE scale and in the delayed recall of words (the ten words test). Adverse effects that led to discontinuation of treatment were not found for both drugs.

Keywords:

poststroke fatigue

prevalence

pathogenesis

diagnostics

treatment

Authors:

Kutlubaev M.A.

Nevrologicheskoe otdelenie Respublikanskoĭ klinicheskoĭ bol'nitsy im. G.G. Kuvatova

SPIN RSCI: 4713-0312
Scopus AuthorID: 9241930700
ORCID: 0000-0003-1001-2024

Akhmadeeva L.R.

Bashkirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Ufa

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References:

Bamdas B.S. Astenicheskie sostoyaniya. M: Medgiz 1961; 198.
Oknin V.Yu. Problema utomleniya, stressa i khronicheskoi ustalosti. Rus med zhurn 2004; 12: 5: 21-28.
Fuhrer R., Wessely S. The epidemiology of fatigue and depression: a French primary-care study. Psychol Med 1995; 25: 5: 895-905.
Staub F. Poststroke fatigue. In: The behavioral and cognitive neurology of stroke. O. Godefroy, J. Bogousslavsky (eds.). Cambridge University Press 2007; 664.
Karvasarskii B.D. Nevrozy (rukovodstvo dlya vrachei). M: Meditsina 1980; 448.
Mel'nichuk P.V., Shtul'man D.R. Infektsionnye i parazitarnye zabolevaniya nervnoi sistemy. V kn.: Bolezni nervnoi sistemy: rukovodstvo dlya vrachei: v 2 tomakh. Tom 1. Pod red. N.N. Yakhno i D.R. Shtul'mana. 3-e izd. M: Meditsina 2003; 744.
Barker-Collo S., Feigin V.L., Dudley M. Post-stroke fatigue - where is the evidence to guide practice? NZ Med J 2007; 26: 120: 1264:2780.
Lerdal A., Bakken L.N., Kouwenhoven S.E. et al. Poststroke fatigue - a review. J Pain Symptom Manage 2009; 38: 6: 928-949.
Chaudhuri A., Behan P.O. Fatigue in neurological disorders. Lancet 2004; 363: 9413: 978-988.
Staub F., Bogousslavsky J. Fatigue after stroke: a major but neglected issue. Cerebrovasc Dis 2001; 12: 2: 75-81.
De Groot M.H., Phillips S.J., Eskes G.A. Fatigue associated with stroke and other neurological conditions: implication for stroke rehabilitation. Arch Phys Med Rehabil 2003; 84: 11: 1714-1720.
Skvortsova V.I., Kontsevoi V.A., Petrova E.A., Savina M.A. Depressiya i paradepressivnye rasstroistva pri tserebral'nom insul'te: voprosy klinicheskoi otsenki, diagnostiki i korrektsii. Zhurn nevrol i psikhiat 2009; 9: 4-11.
Bogousslavsky J. William Feinberg Lecture 2002: emotions, mood and behavior after stroke. Stroke 2003; 34: 1046-1050.
Lynch J., Mead G., Greig C. et al. Fatigue after stroke: the development and evaluation of a case definition. J Psychosom Res 2007; 63: 5: 539-544.
Appelros P. Prevalence and predictors of pain and fatigue after stroke: a population-based study. Int J Rehabil Res 2006; 29: 4: 329-333.
Carlsson G.E., Moller A., Blomstrand C. Consequences of mild stroke in persons <75 years - A 1 year follow-up. Cerebrovasc Dis 2003; 16: 4: 383-388.
Carlsson G.E., Forsberg-Wärleby L., Möller A., Blomstrand B. Comparison of life satisfaction within couples one year after a partner’s stroke. J Rehabil Med 2007; 39: 219-224.
Christinsen D., Johansen S.P., Wau T. et al. Dimensions of poststroke fatigue: a two-year follow-up study. Cerebrovasc Dis 2008; 26: 2: 134-141.
Purebl G., Birkas E., Csoboth C. et al. The relationship of biological and psychological risk factors of cardiovascular disorders in a large-scale national representative community survey. Behav Med 2006; 31: 4: 133-139.
Shepers V.P., Visser-Meily A.M., Ketelaar M., Lindeman E. Post-stroke fatigue: course and its relation to personal and stroke related factors. Arch Phys Med Rehabil 2006; 87: 2: 184-188.
Staub F., Annoni J.M., Gramigna S., Bogousslavsky J. Time-dynamiss of post-stroke fatigue. Cerebrovasc Dis 2004; 17(Suppl 5): 49.
Van de Port I.G., Kwakkel G., Shepers VP. et al. Is fatigue an independent factor associated with activities of daily living, instrumental activities of daily living and health related quality of life in chronic stroke? Cerebrovasc Dis 2007; 23: 1: 40-45.
Van der Werf S.P., van den Broek H.L.P., Anten H.W.M., Bleijenberg G. Experience of severe fatigue long after stroke and its relation to depressive symptoms and disease characteristics. Eur Neurol 2001; 45: 1: 28-33.
Zwarts M.J., Bleijenberg G., van Engelen B.G.M. Clinical neurophysiology of fatigue. Clin Neurophysiol 2008; 119: 1: 2-10.
Michael K. Fatigue and sleep disturbances after stroke. In: «Stroke recovery and rehabilitation» J. Stein (ed.), Demos Medical Publishing 2009: 922.
Smulevich A.B. Depressiya pri somaticheskikh i psikhicheskikh zabolevaniyakh. M: MIA 2003; 432.
Glader E.L., Stegmayr B., Asplund K. Poststroke fatigue: a 2 year follow-up study of stroke patients in Sweden. Stroke 2002; 33: 1327-1333.
Ingles J.L., Eskes G.A., Phillips S.J. Fatigue after stroke. Arch Phys Med Rehabil 1999; 80: 2: 173-178.
Choi-Kwon S., Choi J., Kwon S.U. et al. Fluoxetin is not effective in the treatment of post-stroke fatigue: a double-blind, placebo-controlled study. Cerebrovasc Dis 2007; 23: 2-3: 103-108.
Syed A.B., Castell L.M., Ng A. et al. Plasma glutamate levels predict fatigue after TIA and minor stroke. Cerebrovasc Dis 2007; 23 (Suppl 2): 117.
Annoni J.-M., Staub F., Bogousslavsky J., Brioschi A. Frequency, characterisation and therapies of fatigue after stroke. Neurol Sci 2008; 29 (Suppl 2): 244-246.
Winward C., Sackley C., Metha Z., Rothwell P.M. A population-based study of the prevalence of fatigue after transient ischemic attack and minor stroke. Stroke 2009; 40: 3: 757-761.
Choi-Kwon S., Han S.W., Kwon S.U., Kim J.S. Poststroke fatigue: characteristics and related factors. Cerebrovasc Dis 2005; 19: 2: 84-90.
Staub F., Annoni J.M., Bogousslavsky J. Fatigue after stroke: A pilot Study. Cerebrovasc Dis 2000; 10 (Suppl 2): 62.
Staub F., Annoni J.M., Bogousslavsky J. Post-stroke fatigue: a major problem in "non-disabling" stroke. Cerebrovasc Dis 2002; 13 (Suppl 3): 96.
Naess H., Nyland H.I., Thomassen L. et al. Fatigue at long-term follow-up in young adults with cerebral infarction. Cerebrovasc Dis 2005; 20: 4: 245-250.
Tang W.K., Chen Y.K., Mok V. et al. Acute basal ganglia infarcts in poststroke fatigue: an MRI study. J Neurol 2009; 18.
Colombo B., Martinelli Boneschi F., Rossi P. et al. MRI and motor evoked potential findings in nondisabled multiple sclerosis patients with and without symptoms fatigue. J Neurol 2000; 247: 47: 506-509.
Lou J.S., Kearns G., Benice T. et al. Levodopa improves physical fatigue in Parkinson’s disease: a double-blind, placebo-controlled, crossover study. Mov Dis 2003; 18: 10: 1108-1114.
Owen A.M., Roberts A.C., Hodges J.R. et al. Contrasting mechanisms of impaired attention set-shifting in patients with frontal lobe damage or Parkinson’s disease. Brain 1993; 116: 5: 1159-1175.
Michael K., Allen J.K., Macko R.F. Fatigue after stroke: relationship to mobility, fitness, ambulatory activity, social support and falls efficacy. Rehabil Nurs 2006; 31: 5: 210-217.
Mayo N.E., Poissant L., Weatherall M. et al. Incorporation the International Classification of Functioning, Disability, and Health (ICF) into an electronic health record to create indicators of function: proof of concept using the SF-12. J Am Med Inform Assoc 2004; 11: 6: 514-522.
Lerdal A., Wahl A., Rustoen T. et al. Fatigue in a general population: translation and test of the psychometric properties of the Norwegian version of the Fatigue Severity Scale. Scand J Publ Health 2005; 33: 2: 123-130.
Loge J.H., Ekeberg O., Kaasa S. Fatigue in general Norwegian population: normative data and associations. J Psychosom Res 1998; 45 (1 Spec No): 53-65.
Gramigna S., Schluep M., Staub F. et al. Fatigue in neurological disease: different patterns in stroke and multiple sclerosis. Rev Neurol (Paris) 2007; 163: 3: 341-348.
Shuitemaker G.E., Dinant G.J., Van Den Pol G.A. et al. Vital exhaustion as an indicator for first stroke. Psychosomatics 2004; 45: 2: 114-118.
Kornerup H., Marott J.L., Schnohr P. et al. Vital exhaustion increases the risk of ischemic stroke in women but not in men; results from the Copenhagen City Heart Study. J Psychosom Res 2010; 68: 2: 131-137.
Harbison J.A., Walsh S., Kenny R.A. Hypertension and daytime hypotension found on ambulatory blood pressure is associated with fatigue following stroke and TIA. QJM 2009; 102: 2: 109-115.
Krupp L.B., LaRocca N.G., Muir-Nash J., Steinberg A.D. The Fatigue Severity Scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 1989; 46: 10: 1121-1123.
Ware J., Snow K.K., Kosinski M. SF-36 Health survey: Manual and interpretation guide. Lincoln, RI: Quality Metric Incorporated 2002.
Michielsen H.J., De Vries J., Van Heck G.L. Psychometric qualities of a brief self-rated fatigue measure: The Fatigue Assessment Scale. J Psychosom Res 2003; 54: 4: 345-352.
Smets T.M., Garssen B., Bonke B., De Haes J.C. The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosom Res 1995; 39: 3: 315-325.
McNair D.M., Lorr M. An analysis of mood in neurotics. J Abnorm Social Psychol 1964; 69: 620-7.
Mead G.E., Lynch J., Greig C. et al. Evaluation of fatigue scales in stroke patients. Stroke 2007; 38: 7: 2090-2095.
Smith O.R.F., van den Broek K.C., Renkens M., Denollet J. Comparison of fatigue level in patients with stroke and patients with end-stage heart failure: application of the Fatigue assessment scale. J Am Geriat Soc 2008; 56: 10: 1915-1919.
Mordvintseva E.R. Postinsul'tnaya depressiya: klinicheskie aspekty diagnostiki i podkhody k lecheniyu: Avtoref. dis. … kand. med. nauk. Novosibirsk 2008.
Widar M., Ek A.C., Ahlstrom G. Coping with long-term pain after stroke. J Pain Symptom Manage 2004; 27: 3: 215-225.
Naess H., Waje-Andreassen U., Thomassen L. et al. Health-related quality of life among young adults with ischemic stroke on long term follow-up. Stroke 2006; 37: 5: 1232-1236.
Flinn N.A., Stube J.E. Post-stroke fatigue: qualitative study of three focus groups. Occur Ther Int [Epub ahead of print].
Van de Port I.G., Kwakkel G., van Wijk I., Lindeman E. Susceptibility to deterioration of mobility long-term after stroke: a prospective cohort study. Stroke 2006; 37: 1: 167-171.
Michael K., Macko R.F. Ambulatory activity intensity profile, fitness and fatigue in chronic stroke. Top Stroke Rehabil 2007; 14: 2: 5-12.
Sisson R.A. Life after stroke: coping with change. Rehabil Nurs 1998; 23: 4: 198-203.
Odgen J.A., Mee E.W., Utley T. Too little, too late: does tirilazad mesylate reduce fatigue after subarachnoid hemorrhage? Neurosurgery 1998; 43: 4: 782-787.
Lorig K.R., Ritter P., Stewart A.L. et al. Chronic disease self-management: 2-year health status and health care utilization outcomes. Med Sare 2001; 39: 11: 1217-1223.
McGeough E., Pollock A., Smith L.N. et al. Interventions for post-stroke fatigue. Cochrane Database Syst Rev 2009; 3: 007030.
Glanz M., Kawansky S., Chalmers T. Biofeedback therapy in stroke rehabilitation: a review. J R Soc Med 1997; 90: 1: 33-39.
Harmon R.L., Myers M.A. Prayer and meditation as medical therapies. Phys Med Rehabil Clin N Am 1999; 10: 3: 651-662.
Snyder M., Chlan L. Music therapy. Ann Rev Nurs Res 1999; 17: 3-25.
Wilkes C.N., Shalko T.K., Trahan M. Pet Rx: Implication for good health. Health Educ 1989; 20: 2: 6-9.
Brioschi A., Gramigna S., Werth E. et al. Effect of modafinil on subjective fatigue in multiple sclerosis and stroke patients. Eur Neurol 2009; 62: 4: 243-249.
Baidina T.V., Isakova N.V., Nevostrueva O.N. Dinamika postinsul'tnoi astenii v protsesse vosstanovitel'nogo lecheniya. Vopr kurortol fizioter i LFK 2004; 6: 15-17.
Gurak S.V., Parfenov V.A. Asteniya posle insul'ta i infarkta miokarda i ee lechenie enerionom. Klin gerontol 2005; 8: 9-12.
Kalinskii P.P., Nazarov V.V., Samarets N.N., Ulitin M.N. Osobennosti lecheniya astenicheskogo sindroma v ostrom periode ishemicheskogo insul'ta. Zhurn nevrol i psikhiat 2008; 6: 72-74.