Synergistic efficiency of preformed physical factors and dupilumab in the treatment of polypous rhinosinusitis

Koryagin F.N.; Pelishenko T.G.

doi:https://doi.org/10.17116/rbpdpm2025202116

OBJECTIVE

To evaluate the efficiency of low-intensity laser therapy and mesodyencephalic modulation combined with Dupilumab in the treatment of polypous rhinosinusitis.

MATERIAL AND METHODS

The study enrolled 128 patients with polypous rhinosinusitis. All patients received basic treatment with Nasonex (2 doses 2 times a day) and daily 2-fold washing of nasal mucous membrane. All patients were randomized into 4 groups: group 1 (control, 32 patients) — basic therapy alone, group 2 (comparison group 1, 32 patients) — additional subcutaneous injection of Dupilumab 300 μg once every two weeks, group 3 (comparison group 2, 32 patients) — Dupilumab therapy and low-intensity laser therapy, group 4 (main group, 32 patients) — mesodyencephalic modulation in addition to the treatment in the third group. The results of therapy were evaluated considering severity of polypous rhinosinusitis (Lund-Mackay and Meltzer scales) and SNOT-22 scores. We additionally analyzed the parameters of mucous microcirculation and heart rhythm variability.

RESULTS

Various treatment schemes for polypous rhinosinusitis demonstrated unequal effectiveness. There were minimum changes of indicators in the control group. Dupilumab therapy was followed by significant positive dynamics of clinical indicators. Dupilumab and low-intensity laser contributed to more active regression of the main clinical and functional manifestations of nasal polyposis. The maximum result was noted after integrated use of therapeutic physical factors and dupilumab. Combination of preformed physical factors is accompanied by synergistic interaction and potentiation of clinical effect. The algorithm of correlation adaptometry established higher reserve and adaptive capabilities in the main group.

CONCLUSION

Combination of low-intensity laser therapy and mesodyencephalic modulation with Dupilumab is accompanied by synergistic interaction, higher clinical efficiency regarding normalization of microcirculation and vagosympathetic balance in autonomous regulation.

Keywords:

genetically engineer biological therapy

dupilumab

mesodyencephalmic modulation

low-intensity laser radiation

polypous rhinosinusitis

preformed physical factors

Authors:

Koryagin F.N.

Clinical Hospital No. 1 of the Presidential Administration of the Russian Federation

ORCID: 0000-0002-0603-9059

Pelishenko T.G.

Clinical Hospital No. 1 of the Presidential Administration

ORCID: 0000-0001-6597-2167

Accepted:

18.05.2025

Close metadata

References:

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Получена 20.04.2025