The treatment of patients presenting with metabolic syndrome and "night-piker" arterial hypertension is a most difficult task facing modern therapy. It was shown that metabolic disorders and night-time elevation of arterial pressure in such patients are attributable to obstructive sleep apnea syndrome (OSAS). The present study included 32 patients suffering moderately severe or severe OSAS in conjunction with metabolic syndrome, and "night-piker" arterial hypertension. We tried to elucidate the role of CPAP therapy in the treatment and early rehabilitation of such patients. The study group included 17 patients and the control group was comprised of 15 subjects. The quality of sleep significantly improved in all the patients (100%) during 4 weeks of CPAP therapy; simultaneously, normalization of hemodynamics (the absence of the morning rise in AP) was documented. The morning rise in AP (up to 140/80 mmHg at awakening) persisted in 9 (60%) control patients. The mean cholesterol level decreased by 2.65% and 25.898% in the study and control groups respectively (p>0.1). (all patients in both groups were treated with statins). The level of C-reactive protein decreased more significantly in the study group compared with the control one (38.22% and 13.318% respectively; p<0.05). It is concluded that CPAP therapy produces beneficial effect in the patients with OSAS suffering hypertension during the night or early in the morning. CPAP therapy during 1 month did not have an appreciable effect on metabolic parameters. At the same time, long-term CPAP therapy promoted the reduction in the level of C-reactive protein known to be a predictor of cardiac complications.