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Elfimov D.A.

Tyumen State Medical University

Elfimova I.V.

Tyumen State Medical University

Vasilkova T.N.

Tyumen State Medical University

Fazylgalieva A.F.

Tyumen State Medical University

Nistor E.E.

Tyumen State Medical University

Chronic kidney disease and microcirculation disorders

Authors:

Elfimov D.A., Elfimova I.V., Vasilkova T.N., Fazylgalieva A.F., Nistor E.E.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2025;28(8): 123‑130

DOI: 10.17116/profmed202528081123

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Table of contents

CHRONIC KIDNEY DISEASE AND MICROCIRCULATION DISORDERS
CHRONIC KIDNEY DISEASE AND MICROCIRCULATION DISORDERS

To cite this article:

Elfimov DA, Elfimova IV, Vasilkova TN, Fazylgalieva AF, Nistor EE. Chronic kidney disease and microcirculation disorders. Russian Journal of Preventive Medicine. 2025;28(8):123‑130. (In Russ.)
https://doi.org/10.17116/profmed202528081123

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The literature review presents the data from the study of microvasculature in patients with chronic kidney disease in pre-dialysis period. Relevance of the topic is caused by an increasing number of patients with this pathology. Understanding the role of endothelium in chronic kidney disease will help to develop effective measures to improve kidney microvasculature.

OBJECTIVE

To analyze the data on kidney microvasculature assessment by laser analyzer of capillary blood flow in patients with established chronic kidney disease.

MATERIALS AND METHODS

Literature search in eLibrary, National Library of Medicine PubMed.gov open sources was carried out. Full-text publications in Russian and English describing the state of microvasculature in patients with chronic kidney disease were selected.

RESULTS

We have identified 10 articles corresponding to the objective of our research as a results of publications reviewing. The differences in inclusion and exclusion criteria, features of intervention and outcomes’ development were considered.

CONCLUSION

The role of endothelium is extremely important in studying the development and progression of chronic kidney disease as it’s dysfunction is one of the main causes of this disease occurrence. Correlation between stages of chronic kidney disease and microvasculature state has been identified.

Keywords:

chronic kidney disease
endothelium
endothelial dysfunction
microvasculature

Authors:

Elfimov D.A.

Tyumen State Medical University

Elfimova I.V.

Tyumen State Medical University

Vasilkova T.N.

Tyumen State Medical University

Fazylgalieva A.F.

Tyumen State Medical University

Nistor E.E.

Tyumen State Medical University

Received:

15.04.2025

Accepted:

27.05.2025

Close metadata

References:

  1. Waheed Y, Yang F, Sun D. Role of asymptomatic hyperuricemia in the progression of chronic kidney disease and cardiovascular disease. Korean Journal of Internal Medicine. 2021;36(6):1281-1293. https://doi.org/10.3904/kjim.2020.340
  2. Hill NR, Fatoba ST, Oke JL, et al. Global Prevalence of Chronic Kidney Disease — A Systematic Review and Meta-Analysis. PLOS One. 2016; 11(7):e0158765. https://doi.org/10.1371/journal.pone.0158765
  3. Arefin S, Mudrovcic N, Hobson S, et al. Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeutics. Translational Research. 2025;275:32-47.  https://doi.org/10.1016/j.trsl.2024.11.001
  4. Querfeld U, Mak R, Pries A. Microvascular disease in chronic kidney disease: the base of the iceberg in cardiovascular comorbidity. Clinical Science. 2020;134(12):1333-1356. https://doi.org/10.1042/CS20200279
  5. Prommer HU, Maurer J, von Websky K, et al. Chronic kidney disease induces a systemic microangiopathy, tissue hypoxia and dysfunctional angiogenesis. Scientific Reports. 2018;8(1):5317. https://doi.org/10.1038/s41598-018-23663-1
  6. Li S, Wang F, Sun D. The renal microcirculation in chronic kidney disease: novel diagnostic methods and therapeutic perspectives. Cell and Bioscience. 2021;11(1):90.  https://doi.org/10.1186/s13578-021-00606-4
  7. Zhang X, Agborbesong E, Li X. The Role of Mitochondria in Acute Kidney Injury and Chronic Kidney Disease and Its Therapeutic Potential. International Journal of Molecular Sciences. 2021;22(20):11253. https://doi.org/10.3390/ijms222011253
  8. Barkhatov IV. Laser doppler flowmetry for human blood microcirculation assessment. Kazanskij medicinskij zhurnal. 2014;95(1):63-69. (In Russ.). https://doi.org/10.17816/KMJ1458
  9. Cianci R, Simeoni M, Cianci E, et al. Stem Cells in Kidney Ischemia: From Inflammation and Fibrosis to Renal Tissue Regeneration. International Journal of Molecular Sciences. 2023;24(5):4631. https://doi.org/10.3390/ijms24054631
  10. Chaara S, Bakker W, Eringa E, et al. Effects of dialysis on various microcirculatory beds in end-stage kidney disease (ESKD): a systematic review and meta-analysis. Nephrology Dialysis Transplantation. 2024;39(1): gfae069-0764-2851. https://doi.org/10.1093/ndt/gfae069.764
  11. Bondarenko ON, Yaroslavtseva MV, Tokmakova AYu, et al. Comprehensive assessment of cardiovascular complications in a patient with type 1 diabetes mellitus, chronic kidney disease and diabetic neuroosteoarthropathy. Al’manah klinicheskoj mediciny. 2022;50(3):205-215. (In Russ.). https://doi.org/10.18786/2072-0505-2022-50-031
  12. Chai SC, Sanip Z, Ghulam Rasool AH, et al. Systemic microvascular endothelial function with arteriovenous fistula creation in chronic kidney disease. Journal of Research in Medical Sciences. 2022;27(1):46.  https://doi.org/10.4103/jrms.jrms_908_19
  13. Murkamilova JA, Sabirov IS, Yusupov AF, et al. Structural and functional state of vessels and endothelial dysfunction in chronic kidney disease in patients of elderly and old age. Scientific Heritage. 2021;58(2):52-58. (In Russ.). https://doi.org/10.24412/9215-0365-2021-58-2-52-58
  14. Stepanova TV, Ivanov AN, Tereshkina NE, et al. Markers of endothelial dysfunction: pathogenetic role and diagnostic significance. Klinicheskaya laboratornaya diagnostika. 2019;64(1):34-41. (In Russ.).
  15. Theodorakopoulou M, Zafeiridis A, Dipla K, et al. Muscle Oxygenation and Microvascular Reactivity Across Different Stages of CKD: A Near-Infrared Spectroscopy Study. American Journal of Kidney Diseases. 2023;81(6):655-664.e1.  https://doi.org/10.1053/j.ajkd.2022.11.013
  16. Fursova AZh, Vasilyeva MA, Derbeneva AS, et al. Optical coherence tomography angiography in the diagnosis of retinal microvascular changes in chronic kidney disease (clinical observations). Russian Annals of Ophthalmology. 2021;137(3):97-104. (In Russ.). https://doi.org/10.17116/oftalma202113703197
  17. Shabrov AV, Galenko AS, Uspensky YuP, et al. Methods for diagnosing endothelial dysfunction. Bjulleten’ sibirskoj mediciny. 2021;20(2):202-209. (In Russ.). https://doi.org/10.20538/1682-0363-2021-2-202-209
  18. Nayman A, Seher N, Öztürk M, et al. The role of superb microvascular imaging in detecting low-grade inflammation among adults and those with chronic kidney disease: A preliminary study. Turkish Journal of Medical Sciences. 2023;53(3):692-700.  https://doi.org/10.55730/1300-0144.5632
  19. Dynnik OB, Marunchin NA, Mostovoy SE. Endothelial dysfunction in clinical practice: the role of laser Doppler flowmetry (literature review). Mezhdunarodny`j e`ndokrinologicheskij zhurnal. 2019;15(4):358-362. (In Ukrain.). https://doi.org/10.22141/2224-0721.15.4.2019.174826
  20. Guigui A, Loader J, Bellier A, et al. Commentary: Multiple laser doppler flowmetry probes increase the reproducibility of skin blood flow measurements. Frontiers in Physiology. 2022;13:1025905. https://doi.org/10.3389/fphys.2022.1025905
  21. Lipatova IO, Araslanova VM, Konstantinova TD, et al. Laser Doppler Fowmetry Estimates Laser Therapy Efficiency in the Combined Treatment of Obliterating Atherosclerosis of Lower Limbs. Lazernaja medicina. 2003;7(2): 15-19. (In Russ.).
  22. Tsapaeva NL, Tsapaev VG. Microcirculation (part 2): «Functional responsibilities» of microcirculation system. Neotlozhnaya kardiologiya i kardiovaskulyarnye riski. 2024;8(1):2063-2072. (In Russ.). https://doi.org/10.51922/2616-633X.2024.8.1.2063
  23. Vasilev P, Shishkin A, Erofeev N, et al. Laser doppler flowmetry in studying of microvascular disorders in patients with diabetic nephropathy. Nephrology Dialysis Transplantation. 2021;36(1):gfab094.008.  https://doi.org/10.1093/ndt/gfab094.008
  24. Melsens K, Van Impe S, Paolino S, et al. The preliminary validation of laser Doppler flowmetry in systemic sclerosis in accordance with the OMERACT filter: A systematic review. Seminars in Arthritis and Rheumatism. 2020; 50(2):321-328.  https://doi.org/10.1016/j.semarthrit.2019.08.007
  25. Williams J, Gilchrist M, Fraser D, et al. P1161 Cutaneous microcirculatory dysfunction in peritoneal dialysis patients. Nephrology Dialysis Transplantation. 2020;35(3):gfaa142.P1161. https://doi.org/10.1093/ndt/gfaa142.P1161
  26. Girkantaite Z, Laucyte-Cibulskiene A, Ryliskyte L, et al. Laser Doppler flowmetry evaluation of skin microvascular endothelial function in patients with metabolic syndrome. Microvascular Research. 2022;142:104373. https://doi.org/10.1016/j.mvr.2022.104373
  27. Borges PS, Orange FA, Pontes IA, et al. Impaired Microvascular Reactivity in Patients with Chronic Kidney Disease Submitted to Kidney Transplantation: A Prospective Observational Study. Kidney and Blood Pressure Research. 2024;49(1):619-629.  https://doi.org/10.1159/000540047
  28. Statsenko ME, Derevyanchenko MV, Titarenko MN, et al. Skin Microcirculation Violations In Hypertensive Diabetic Patients According To The Stage Of Chronic Kidney Disease. Nefrologiya. 2015;19(5):57-63. (In Russ.).
  29. Romasheva EP, Bulgakova SV, Tretiakova VV, et al. The State Of Endothelium In Elderly Patients With Chronic Kidney Disrease. Aspirantskiy Vestnik Povolzhiya. 2016;16(1-2):116-119. (In Russ.).
  30. Nizeyamova AR, Kurapova MV, Romasheva EP, et al. Microcirculation In Patients With Chronic Kidney Disease, On Hemodialysis. Mezhdunarodnyj nauchno-issledovatel’skij zhurnal. 2014;3(22):96-97. (In Russ.).
  31. Klinicheskie rekomendatsii. Khronicheskaya bolezn’ pochek (KhBP). 2024. Accessed March 24, 2025. (In Russ.). https://cr.minzdrav.gov.ru/view-cr/469_3
  32. Rumyantseva EI, Avksentieva MV. Clinical and economic efficiency of screening to detect chronic kidney disease in the Russian Federation. Russian Journal of Preventive Medicine. 2024;27(7):7-15. (In Russ.). https://doi.org/10.17116/profmed2024270717
  33. Li T, Hu Z, Qiao L, et al. Chronic kidney disease and cognitive performance: NHANES 2011-2014. BMC Geriatrics. 2024;24:351.  https://doi.org/10.1186/s12877-024-04917-2
  34. Seliger SL, Salimi S, Pierre V, et al. Microvascular endothelial dysfunction is associated with albuminuria and CKD in older adults. BMC Nephrology. 2016;17:82.  https://doi.org/10.1186/s12882-016-0303-x
  35. Thang OH, Serné EH, Grooteman MP, et al. Premature aging of the microcirculation in patients with advanced chronic kidney disease. Nephron Extra. 2012;2(1):283-292.  https://doi.org/10.1159/000343295
  36. Kurapova MV, Nizyamova AR, Romasheva EP, et al. Osobennosti mikrotsirkulyatornogo rusla u bol’nykh khronicheskoi pochechnoi nedostatochnost’yu. Vestnik medicinskogo instituta «REAVIZ»: reabilitacija, vrach i zdorov’e. 2012;1(5):5-7. (In Russ.).
  37. Kurapova MV, Nizyamova AR, Romasheva EP, et al. The Feature Basal Blood Flow in Patient with Chronic Kidney Disease. Mezhdunarodnyj nauchno-issledovatel’skij zhurnal. 2014;3(22):80-81. (In Russ.).
  38. Kirkman DL, Muth BJ, Ramick MG, et al. Role of mitochondria-derived reactive oxygen species in microvascular dysfunction in chronic kidney disease. American Journal of Physiology. Renal Physiology. 2018;314(3):F423-F429. https://doi.org/10.1152/ajprenal.00321.2017
  39. Luck JC, Kunselman AR, Herr MD, et al. Multiple Laser Doppler Flowmetry Probes Increase the Reproducibility of Skin Blood Flow Measurements. Frontiers in Physiology. 2022;13:876633. https://doi.org/10.3389/fphys.2022.876633
  40. Landyshev YS, Scherban NA, Tkacheva SI. Features of the mechanisms of regulation of vascular tone of the microcirculatory channel of bronchial mucosa in chronic kidney disease. Dal’nevostochnyj medicinskij zhurnal. 2009; 1:5-8. (In Russ.).
  41. Scherban NA, Landyshev YS, Tseluiko SS. The morphological and functional characteristic of microcirculation of bronchial tubes in patients with chronic renal insuffi ciency. Dal’nevostochnyj medicinskij zhurnal. 2009; 4:19-21. (In Russ.).
  42. Fedorovich AA, Markov DS, Malishevsky MV, et al. Microcirculatory disorders in the forearm skin in the acute phase of COVID-19 according to laser Doppler flowmetry. Regionarnoe krovoobrashhenie i mikrocirkuljacija. 2022;21(3):56-63. (In Russ.). https://doi.org/10.24884/1682-6655-2022-21-3-56-63
  43. Babos L, Járai Z, Nemcsik J. Evaluation of microvascular reactivity with laser Doppler flowmetry in chronic kidney disease. World Journal of Nephrology. 2013;2(3):77-83.  https://doi.org/10.5527/wjn.v2.i3.77
  44. Lobov GI, Isachkina AN, Gurkova AS. Features of microvasculature regulation in patients with chronic kidney disease on peritoneal dialysis. Regionarnoe krovoobrashhenie i mikrocirkuljacija. 2016;15(1):65-72. (In Russ.). https://doi.org/10.24884/1682-6655-2016-15-1-65-72
  45. Сивцева Е.М. Роль эндотелиальной дисфункции в прогрессировании хронических заболеваний почек у детей. Российский вестник перинатологии и педиатрии. 2011;56(1):112-132. 
  46. Sivtseva EM. Role of endothelial dysfunction in the progression of chronic kidney disease in children. Rossiyskiy vestnik perinatologii i pediatrii. 2011; 56(1):112-132. (In Russ.).
  47. Yao J, Sprick JD, Jeong J, et al. Differences in peripheral microcirculatory blood flow regulation in chronic kidney disease based on wavelet analysis of resting near-infrared spectroscopy. Microvascular Research. 2024; 151:104624. https://doi.org/10.1016/j.mvr.2023.104624
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