The use of modern topical medications for the stepwise treatment of allergic rhinitis: the effectiveness and prospects for the further extension of their application

Close metadata

The objective of the present work was to summarize the results of clinical studies designed to evaluate the effectiveness of «Momate Rhino Advance» in the form of the nasal spray (based on the fixed combination of mometasone furoate and azelastine) that finds an increasingly wide application for the treatment of allergic rhinitis. The available data give evidence that this medication can be prescribed to the patients presenting with the severe and moderate form of allergic rhinitis. The treatment should be started with the use of the combined preparation and continued, after the adequate control of the clinical symptoms of allergic rhinitis is achieved, using «Momate Rhino» during the next 2—4 weeks for the reliable management of the disease. It is concluded that the proposed strategy makes it possible to avoid the simultaneous application of multiple medications (polypragmasy) and thereby reduce the intake of medicines by the patients suffering from allergic rhinitis.

Keywords:

allergic rhinitis

stepwise therapy

azelastine

mometasone furoate

Authors:

Nosulia E.V.

Kim I.A.

Kafedra otorinolaringologii RMAPO, Moskva

List of references:

Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, To- gias A, Zuberbier T, Baena-Cagnani CE, Canonica GW, van Weel C, Agache I, Aït-Khaled N, Bachert C, Blaiss MS. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and Aller-Gen). Allergy. 2008;63(suppl 86):8-160.
Braback L, Hjern A, Rasmussen F Body mass index, asthma and allergic rhinoconjunctivitis in Swedish conscripts-a national cohort study over three decades. Respir Med. 2005;99(8):1010-1014.
Varner AE. The increase in allergic respiratory diseases: survival of the fittest? Allergy Diagnostic Chest. 2002;121(4):1308-1316.
Ilyina NI, Polder SA. Kruglogodichny allergichesky rinit. Consillium medicum. 2001;3:8. (In Russ.).
Ilyina NI. Epidemiologiya allergicheskogo rinita. Rossyskaya rinologiya. 1999;1:23-24. (In Russ.).
Bellanti JA, Wallerstedt DB. Allergic rhinitis update: Epidemiol- ogy and natural history. Allergy Asthma Proc. 2000;21(6):367-370.
Skoner DP. Allergic rhinitis: definition, epidemiology, pathophys- iology, detection, and diagnosis. J Allergy Clin Immunol. 2001;108(1 suppl):2-8.
Sibbald B, Rink E. Epidemiology of seasonal and perennial rhini- tis: clinical presentation and medical history. Thorax. 1991;46(12):895-901.
Dogru M. Investigation of asthma comorbidity in children with different severities of allergic rhinitis. Am J Rhinol Allergy. 2016;30(3):186-189. doi:10.2500/ajra.2016.30.4315
Sacre Hazouri JA. Allergic rhinitis. Coexistent diseases and complications. A review and analysis. Rev Alerg Mex. 2006;53(1):9-29.
Benninger MS, Sindwani R, Holy CE, Hopkins C Impact of medically recalcitrant chronic rhinosinusitis on incidence of asthma. Int Forum Allergy Rhinol. 2016;6(2):124-129. doi:10.1002/alr.21652
Rosati MG, Peters AT. Relationships among allergic rhinitis, asthma, and chronic rhinosinusitis. Am J Rhinol Allergy. 2016;30(1):44-47. doi:10.2500/ajra.2016.30.4252
Fireman P. Otitis media and eustachian tube dysfunction: connection to allergic rhinitis. J Allergy Clin Immunol. 1997;99(2):S 787-97.
Ruggeri C, Barberio G, Pajno GB, Putortì A, Morabito L, Pollicino A, Febbraro R. Relations between allergic rhinitis and otitis media with effusion. The role of the Eustachian tube. Minerva Pediatr. 1990;42(11):481-483.
Cheng X, Sheng H, Ma R, Gao Z, Han Z, Chi F, Cong N, Wang J, Liu X, Luo X, Yu J, Ra Y. Allergic rhinitis and allergy are risk factors for otitis media with effusion: A meta-analysis. Allergol Immunopathol (Madr). 2017;45(1):25-32. doi:10.1016/j.aller.2016.03.004
Modrzyński M, Zawisza E. Frequency of adenoid hypertrophy in children with allergic diseases. Przegl Lek. 2003;60(5):322-324.
Sih T, Mion O.Allergic rhinitis in the child and associated comorbidities. Pediatr Allergy Immunol. 2010;21(1 Pt 2):107-113. doi:10.1111/j.1399-3038.2009.00933.x
Graf P. Rhinitis medicamentosa: aspects of pathophysiology and treatment. Allergy. 1997;52(supp 140):28-34.
Lin CY, Cheng PH, Fang SY. Mucosal changes in rhinitis medicamentosa. Ann Otol Rhinol Laryngol. 2004113(2):147-151.
Federalnye klinicheskiye rekomendatsii po diagnostike i lecheniyu allergicheskogo rinita. M. 2013. (In Russ.).
Luss LV. Vybor antigistaminnykh preparatov v lechenii allergicheskikh i psevdoallergicheskikh reaktsy. Astma ta alergіya. 2010;1-2:70-76. (In Russ.).
Luss LV. Antigistaminnye preparaty dlya parenteralnogo vvedeniya. Fenkarol — pervy antigistaminny preparat bez vyrazhennogo sedativnogo effekta dlya parenteralnogo vvedeniya. Rossysky Allergologichesky Zhurnal. 2015;1:54-59. (In Russ.).
Bernstein JA. Azelastine hydrochloride: a review of pharmacology, pharmacokinetics, clinical efficacy and tolerability. Curr Med Res Opin. 2007;23(10):2441-2452.
Meltzer EO, Jalowayski AA, Orgel HA, Harris AG. Subjective and objective assessments in patients with seasonal allergic rhinitis: ef- fects of therapy with mometasone furoate nasal spray. J Allergy Clin Immunol. 1998;102(1):39-49.
Minshall E, Ghaffar O, Cameron L, O’Brien F, Quinn H, Rowe- Jones J, Davies RJ, Prior A, Lund VJ, Mackay IS, Nolop K, Lutsky B, Durham SR, Hamid Q. Assessment by nasal biopsy of long-term use of mometasone furoate aqueous nasal spray (Na- sonex) in the treatment of perennial rhinitis. Otolaryngol Head Neck Surg. 1998;118(5):648-654.
Frieri M, Therattil J, Chavarria V, Cosachov J, Kumar NS, Wang SF, Sansone G, Etzel J, Dellevecchia D, Zitt M, Mesarina-Wicki B, Nolop KB. Effect of mometasone furoate on early and late phase inflammation in patients with seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 1998;81(5):431-437.
Hampel FC, Ratner PH, Van Bavel J, Amar NJ, Daftary P, Wheeler W, Sacks H. Double-blind, placebo-controlled study of azelastine and fluticasone in a single nasal spray delivery device. Ann Allergy Asthma Immunol. 2010;105(2):168-173. doi:10.1016/j.anai.2010.06.008
Wolthers OD. New patents of fixed combinations of nasal antihis- tamines and corticosteroids in allergic rhinitis. Recent Pat Inflamm Allergy Drug Discov. 2013;7(3):223-228.
Bernstein JA. Azelastine hydrochloride: a review of pharmacology, pharmacokinetics, clinical efficacy and tolerability. Curr Med Res Opin. 2007;23(10):2441-2452.  Bernstein JA. MP29-02: a breakthrough for the treatment of allergic rhinitis. Expert Opin Pharmacother. 2013;14(15):2101-2113. doi:10.1517/14656566.2013.828693
Nenasheva NM. Effektivnost preparata Momat rino advans u vzroslykh bolnykh seozonnym allergicheskim rinitom. Rezultaty randomizirovannogo otkrytogo multitsentrovogo klignicheskogo issledovaniya. Rossyskaya rinologiya. 2016;2:137-147. (In Russ.).
Nenasheva NM, Ilyina NI, Berdnikova NG. Effektivnost i bezopasnost preparata Momat Rino (mometazona furoat v vide spreya nazalnogo dozirovannogo) u vzroslykh patsiyentov s kruglogodichnym allergicheskim rinitom: rezultaty randomizirovannogo otkrytogo multitsentrovogo klinicheskogo issledovaniya. Consilium medicum. 2016;11:102-109. (In Russ.).

Close metadata