The role of topical glucocorticoids in the treatment of rhinosinusitis

Shakhova E.G.

doi:https://doi.org/10.17116/otorino201782270-73

Shakhova E.G.

Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russian Federation,

The role of topical glucocorticoids in the treatment of rhinosinusitis

Authors:

Shakhova E.G.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2017;82(2): 70‑73

DOI: 10.17116/otorino201782270-73

Read: 5347 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Shakhova EG. The role of topical glucocorticoids in the treatment of rhinosinusitis. Russian Bulletin of Otorhinolaryngology. 2017;82(2):70‑73. (In Russ.)
https://doi.org/10.17116/otorino201782270-73

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Pneumatization of the middle turbinate and chronic sinusitis: current state of the problem and review of surgical correction. Russian Bulletin of Otorhinolaryngology. 2025;(1):69-74

Experimental and clinical evaluation of the safety and efficacy of Polydexa spray with phenylephrine in acute rhinosinusitis. Russian Bulletin of Otorhinolaryngology. 2025;(4):39-46

The role of Inflasinusans in the treatment of acute rhinosinusitis. Russian Bulletin of Otorhinolaryngology. 2025;(4):64-71

Contradictory indications for rhinosinus surgery in children with rhinogenic headaches. Russian Bulletin of Otorhinolaryngology. 2025;(6):111-118

A Randomized Controlled Trial Comparing Budesonide and Mometasone Furoate Nasal Spray in the Treatment of Chronic Rhinosinusitis with Nasal Polyposis: Evaluating Symptom Scores and Quality of Life. Russian Rhinology. 2025;(1):12-17

Results of olfactory examination in patients with rhinosinusitis based on various olfactory tests. Russian Rhinology. 2025;(4):6-12

Abstract:

The guidelines of the European position paper on rhinosinusitis and nasal polyps (EPOS, 2012) ascribe the highest strength and the most comprehensive evidence-based significance to the application of intranasal glucocorticosteroids (inGCS) as the first-line therapy for the patients presenting with acute and polypous rhinosinusitis; moreover they are recommended as the medications of choice for the treatment of chronic rhinosinusitis in the absence of polyps. The author presents the data concerning the mechanism of action, clinical effectiveness, and safety of inGCS used for the treatment of acute, recurrent, and chronic rhinosinusitis. It is shown that mometason furoate produces the favourable therapeutic effect and is possessed of beneficial pharmacodynamic and pharmacokinetic properties in the cases of its topical application. The comparative randomized clinical study (RCS) of the new preparation of mometason furoate in the form of the intranasal spray (manufactured by «Teva» Ltd.) registered in the Russian Federation in 2015 has demonstrated that it can be considered as a therapeutic equivalent to nasonex.

Keywords:

rhinosinusitis

intranasal glucocorticosteroids

mometason furoate

Dezrinit

Authors:

Shakhova E.G.

Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russian Federation,

Close metadata

References:

Bhattacharyya N. Contemporary assessment of the disease burden of sinusitis. Am J Rhinol Allergy. 2009;23:392-395.
Walker TJ, Younis R. Acute and Chronic Rhinosinusitis in Encyclopedia of Otolaryngology (Stilianos E. Kountakis. Editor). Head and Neck Surgery. 2013;39-46. doi:10.1007/978-3-642-23499-6_457
Fandifio M, Macdonald KL, Lee J, Witterick IJ. The use of postoperative topical corticosteroids in chronic rhinosinusitis with nasal polyps: a systemic review and meta-analysis. Am J Rhinol Allergy. 2013;27(5):146-157. doi:10.2500/ajra.2013.27.3950
Bernstein JA, Davis BP, Picard JK, Cooper JP, Zheng S, Levin LS. A randomized, double-blind, parallel trial comparing capsaicin nasal spray with placebo in subjects with a significant component of nonallergic rhinitis. Ann Allergy Asthma Immunol. 2011;107(2):171-178. doi:10.1016/j.anai.2011.05.016
Dykewicz MS, Hamilos DL. Rhinitis and sinusitis. J Allergy Clin Immunol. 2010;125(2 suppl 2):103-115. doi:10.1016/j.jaci.2009.12.989
Shakhova EG. Comparative effectivness of the combinad treatment with antibiotic and secretolitic at patients with acute purulent rhinosinusitis. Rossiiskaya otorinolaringologiya. 2010;2:170-175. (In Russ.).
Zaytsev VA, Shakhova EG, Pelikh EV. Epidemiology of chronic polypous rhinosinusitis in volgograd region of Russia. Ros otorinolar. 2013;5:39-43. (In Russ.).
Brook I. Acute and chronic bacterial sinusitis. Infect Dis Clin North Am. 2007;21(2):427-448. doi:10.1016/j.idc.2007.02.001
Chow AW, Benninger MS, Brook I, Brozek JL, Goldstein EJ, Hicks LA, Pankey GA, Seleznick M, Volturo G, Wald ER, File Jr TM. IDSA Clinical Practice Guideline for Acute Bacterial Rhinosinusitis in Children and Adults. Clinical Infectious Diseases. 2012;54(8):1041-1045. doi:10.1093/cid/cir1043
Brook I. Treatment modalities for bacterial rhinosinusitis. Expert Opin Pharmacother. 2010;11:755-769.
Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, Cohen N, Cervin A, Douglas R, Gevaert P, Georgalas C, Goossens H, Harvey R, Hellings P, Hopkins C, Jones N, Joos G, Kalogjera L, Kern B, Kowalski M, Price D, Riechelmann H, Schlosser R, Senior B, Thomas M, Toskalaw E, Voegels R, Wang DY, Wormald PJ. European Position Paper on Rhinosinusitis and Nasal Polyps. 2012;(rhinol suppl);23:3.
Abdulkerimov KhT, Garashchenko TI, Koshel' VI, Ryazantsev SV, Svistushkin VM. Printsipy etiopatogeneticheskoi terapii ostrykh sinusitov. Metodicheskie rekomendatsii. Pod red. Ryazantseva S.V. SPb.: Poliforum Grupp; 2015. (In Russ.).
Etiopatogeneticheskaya terapiya zabolevanii verkhnikh dykhatel'nykh putei i ukha: metodicheskie rekomendatsii. Pod red. Ryazantseva S.V. SPb.: Poliforum Grupp; 2015. (In Russ.).
Meltzer EO, Charous BL, Busse WW, Zinreich SJ, Lorber RR, Danzig MR. Added relief in the treatment of acute 66 recurrent sinusitis with adjunctive mometasonefuroate nasal spray. The Nasonex Sinusitis Group. J Allergy Clin Immunol. 2000;10:106(4):630-637. doi:10.1067/mai.2000.109056
Meltzer EO, Bachert C, Staudinger H. Treating acute rhinosinusitis: comparing effi cacy and safety of mometasonefuroate nasal spray, amoxicillin, and placebo. J Allergy Clin Immunol. 2005;116:1289-1295. doi:10.1016/j.jaci.2005.08.044
Aukema AAC, Mulder PGH, Fokkens WJ. Treatment of nasal polyposis and chronic rhinosinusitis with fl uticasone propionate nasal drops reduces need for sinus surgery. J Allergy ClinImmunol. 2005;115:1017-1023. doi:10.1016/j.jaci.2004.12.1144
Pornsuriyasak P, Assanasen P. Intranasal Corticosteroid. Siriraj Med J. 2008;60:90-95.
Valera FCP, Tamashiro E, Anselmo-Lima WT. Glucocorticoid Resistance in the Upper Respiratory Airways. Chapter 20. 2012. doi:10.5772/53105
Ryan D. Management of acute rhinosinusitis in primary care: changing paradigms and the emerging role of intranasal corticosteroids. Primary Care Respiratory Journal. 2008;17(3):148-155. doi:10.3132/pcrj.2008.00050
Lopatin AS, Ivanchenko OA. Acute and chronic rhinosinusitis: new theories and unanswered questions. Meditsinskii sovet. 2011;9-10:52-57. (In Russ.).
Derendorf H, Meltzer EO. Molecular and clinical pharmacology of intranasal corticosteroids: clinical and therapeutic implications. Allergy. 2008;63(10):1292-1300. doi:10.1111/j.1398-995.2008. 01750.x
Suzaki H. Action mechanisms of glucocorticoids on rhinosinusitis. Asian Rhinology Journal. 2013;1:3-13.
Passali D, Spinosi MC, Crisanti A, Bellussi LM. Mometasonefuroate nasal spray: a systematic review. Multidiscip Respir Med. 2016;11:18. doi:s40248-016-0054-3
Ilina NI, Fedoskova TG, Astafieva NG, Gorychkina LA, Edin AS, Lopatin AS, Ukhanova OP, Khanova FM, Khanferyan RA. Therapeutic comparability of Dezrinit and Nazonex in control of symptoms of allergic rhinitis. The results of a multicenter, open, randomized, comparative study in parallel groups. Rossiiskii allergologicheskii zhurnal. 2016;3:65-74. (In Russ.).