Peculiar features of immunological and metabolic status associated with polypous rhinosinusitis

Kolenchukova O.A.

Research Institute of Medical Problems of the North, Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russia, 660022

Smirnova S.V.

Kafedra detskoĭ khirurgii Rossiĭskogo nauchno-issledovatel'skogo meditsinskogo universiteta im. N.I. Pirogova, Moskva

Lapteva A.M.

Research Institute of Medical Problems of the North, Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russia, 660022

Peculiar features of immunological and metabolic status associated with polypous rhinosinusitis

Authors:

Kolenchukova O.A., Smirnova S.V., Lapteva A.M.

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Journal: Russian Bulletin of Otorhinolaryngology. 2015;80(6): 22‑27

DOI: 10.17116/otorino201580622-27

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To cite this article:

Kolenchukova OA, Smirnova SV, Lapteva AM. Peculiar features of immunological and metabolic status associated with polypous rhinosinusitis. Russian Bulletin of Otorhinolaryngology. 2015;80(6):22‑27. (In Russ.)
https://doi.org/10.17116/otorino201580622-27

Подписка 2025 (Russian Bulletin of Otorhinolaryngology)

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The objective of the present work was to study peculiar features of immunological and metabolic status associated with polypous rhinosinusitis (PRS). We determined the population and subpopulation composition of blood lymphocytes, concentration of cytokines in blood sera and nasal secretion as well as the level of intracellular enzymes in blood lymphocytes of the patients presenting with polypous rhinosinusitis and of the control subjects. It was shown that PRS was associated with activation of Th1-lymphocytes and determined the character of the immune response largely of the cell-mediated type. The study has demonstrated the differently directed changes in the activation of the intracellular processes in blood lymphocytes. Specifically, the intensity of the aerobic processes and lipid anabolism was increased while that of the anaerobic processes and amino acid metabolism (NAD-GDG and NADH-GDG) was suppressed

Keywords:

polypous rhinosinusitis

lymphocytes

cytokines

enzymes

metabolism

Authors:

Kolenchukova O.A.

Research Institute of Medical Problems of the North, Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russia, 660022

Smirnova S.V.

Kafedra detskoĭ khirurgii Rossiĭskogo nauchno-issledovatel'skogo meditsinskogo universiteta im. N.I. Pirogova, Moskva

Lapteva A.M.

Research Institute of Medical Problems of the North, Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russia, 660022

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