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Yusef Yu.

Krasnov Research Institute of Eye Diseases

Surnina Z.V.

Krasnov Research Institute of Eye Diseases

Sheludchenko V.M.

Krasnov Research Institute of Eye Diseases

Ermakova S.V.

Krasnov Research Institute of Eye Diseases

Sheludchenko N.V.

Krasnov Research Institute of Eye Diseases

Results of corneal confocal microscopy in cavitation-related complications of femtosecond LASIK

Authors:

Yusef Yu., Surnina Z.V., Sheludchenko V.M., Ermakova S.V., Sheludchenko N.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2025;141(6): 63‑68

DOI: 10.17116/oftalma202514106163

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Table of contents

RESULTS OF CORNEAL CONFOCAL MICROSCOPY IN CAVITATION-RELATED COMPLICATIONS OF FEMTOSECOND LASIK
RESULTS OF CORNEAL CONFOCAL MICROSCOPY IN CAVITATION-RELATED COMPLICATIONS OF FEMTOSECOND LASIK

To cite this article:

Yusef Yu, Surnina ZV, Sheludchenko VM, Ermakova SV, Sheludchenko NV. Results of corneal confocal microscopy in cavitation-related complications of femtosecond LASIK. Russian Annals of Ophthalmology. 2025;141(6):63‑68. (In Russ.)
https://doi.org/10.17116/oftalma202514106163

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Keratorefractive surgical procedures have become widely used in recent years. However, during femtosecond LASIK, a number of intraoperative cavitation-related complications may occur, one of which is the formation of an opaque bubble layer (OBL). This necessitates careful postoperative monitoring of corneal status. One of the most effective diagnostic methods in such clinical situations is corneal confocal microscopy (CCM), which has proven to be a reliable tool for visualizing all corneal layers, including in keratorefractive surgery. However, the characteristics of OBL revealed using this technique have not yet been adequately studied.

PURPOSE

This study aimed to evaluate the potential of CCM using an original algorithm for confocal image analysis in patients with and without OBL in randomized groups.

MATERIAL AND METHODS

The study included 45 patients (90 eyes) with myopia (mean −5.0 D). Participants were divided into two groups: the study group consisting of individuals with OPL, and the comparison group (patients without this complication). In all cases, visual acuity assessment, refractometry, and CCM were performed with acquisition of images of various corneal layers before femto-LASIK and at 1, 4, 12, and 24 weeks postoperatively. Liner Calculate, a proprietary software program, was used to analyze the dimensions of the OPL zone.

RESULTS

Destructive changes in keratocytes were more pronounced in patients with OBL compared to those in the femtosecond LASIK group without the complication. The depth of stromal damage was also increased; blurred cell boundaries and increased size and reflectivity of keratocyte nuclei were observed in all study participants. At 6 months postoperatively, complete restoration of the corneal stromal layers was not achieved in either group. Morphological and structural keratocyte abnormalities persisted by the end of this period, and were more pronounced in patients with OBL.

CONCLUSION

The formation of OBL after femtosecond LASIK is associated with more extensive destructive keratocyte changes, which prolongs the corneal stromal recovery period.

Keywords:

myopia
femto-LASIK
opaque bubble layer
corneal confocal microscopy

Authors:

Yusef Yu.

Krasnov Research Institute of Eye Diseases

Surnina Z.V.

Krasnov Research Institute of Eye Diseases

Sheludchenko V.M.

Krasnov Research Institute of Eye Diseases

Ermakova S.V.

Krasnov Research Institute of Eye Diseases

Sheludchenko N.V.

Krasnov Research Institute of Eye Diseases

Received:

15.04.2025

Accepted:

15.09.2025

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References:

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