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Safonova T.N.

Krasnov Research Institute of Eye Diseases

Zaitseva G.V.

Krasnov Research Institute of Eye Diseases

Cell technologies as a basis for the development of regenerative principles for the treatment of lacrimal gland diseases

Authors:

Safonova T.N., Zaitseva G.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2024;140(2‑2): 158‑165

DOI: 10.17116/oftalma2024140022158

Views: 779

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To cite this article:

Safonova TN, Zaitseva GV. Cell technologies as a basis for the development of regenerative principles for the treatment of lacrimal gland diseases. Russian Annals of Ophthalmology. 2024;140(2‑2):158‑165. (In Russ.)
https://doi.org/10.17116/oftalma2024140022158

Подписка 2025 (Russian Annals of Ophthalmology)
 
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The lacrimal gland (LG) is a tubuloacinar exocrine gland composed of acinar, ductal, and myoepithelial cells. Three-dimensional distribution of acinar lobules, ducts, and myoepithelial cells is necessary for the effective functioning of the organ. LG is the main organ of immune surveillance of the ocular surface system. The embryogenesis of the gland is regulated by the interaction of genetic mechanisms, internal epigenetic (enzyme systems, hormones) and exogenous factors. There is no doubt that there is a clear genetic program for the implementation of the complex process of embryonic development. The mechanisms regulating LG organogenesis initiate the work of a huge number of structural oncogenes, transcription and growth factors, etc. Studying the expression and selective activity of regulatory genes during organ development, their participation in the differentiation of different cell types is a current trend at the nexus of clinical genetics, molecular biology, embryology and immunocytochemistry. Due to its relatively simple structure and accessibility, human LG is a suitable object for potential application in regenerative medicine. Development of a universal protocol for obtaining functional differentiated secretory epithelium of LG capable of expressing tissue-specific markers is an urgent task. Determining the nature and origin of stem cells and progenitor cells will allow the isolation and multiplication of these cells in culture. After obtaining a functionally active culture of LG cells, it is possible to create a model of autoimmune diseases.

Keywords:

regenerative medicine
cell culture
lacrimal gland embryogenesis
stem cells
dacryoadenitis

Authors:

Safonova T.N.

Krasnov Research Institute of Eye Diseases

Zaitseva G.V.

Krasnov Research Institute of Eye Diseases

Received:

14.09.2023

Accepted:

17.10.2023

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