The effect of sex hormones and pregnancy on development and progression of uveal melanoma

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The analysis of literature revealed that men experience uveal melanoma (UM) more frequently and with worse prognosis. There are also descriptions of an aggressive course of UM in pregnant women. These facts prompted researchers to analyze the effect of sex hormones and pregnancy on the development and progression of UM. Many years of international experience have refuted the presence of a reliable difference between 5-year survival and 5-year survival without metastases between non-pregnant women with UM and pregnant women with UM. That data is regarded as level 3 evidence. The experts have concluded that UM is not a contraindication to current or future pregnancy, and exogenous hormones (oral contraceptives or hormone replacement therapy) do not affect the incidence and prognosis of UM. Publications provide evidence of expression of the receptors of certain sex hormones (ER, ERRα, LH and LHRH) in primary UM, as well as overexpression of the ESR1 and ESR2 genes in UM with poor predictive characteristics. Overall AR mRNA expression in UM was low, but it was higher in epithelial UMs. The fact of expression of estrogen receptors in UM gives grounds to experiment with them as a target for therapy.

Keywords:

uveal melanoma

hormones

pregnancy

reproductive functions

prognosis

Authors:

Likhvantseva V.G.

Federal Medical Biophysical Center named after A.I. Burnazyan of the Federal Medical-Biological Agency;
Academy of Postgraduate Education of the Federal Scientific-Clinical Center of Specialized Types of Medical Care and Medical Technologies of the Federal Medical-Biological Agency

Ovanesyan V.E.

Yegoryevsk Central District Hospital

Received:

21.10.2021

Accepted:

29.11.2021

List of references:

Miller M, Schoenfield L, Abdel-Rahman M, Cebulla CM. Is Uveal Melanoma a Hormonally Sensitive Cancer? A Review of the Impact of Sex Hormones and Pregnancy on Uveal Melanoma. Ocul Oncol Pathol. 2021;7(4): 239-250. https://doi.org/10.1159/000514650
Singh AD, Turell ME, Topham AK. Uveal melanoma: trends in incidence, treatment, and survival. Ophthalmology. 2011;118(9):1881-1885. https://doi.org/10.1016/j.ophtha.2011.01.040
Zloto O, Pe’er J, Frenkel S. Gender differences in clinical presentation and prognosis of uveal melanoma. Invest Ophthalmol Vis Sci. 2013;54(1):652-656. https://doi.org/10.1167/iovs.12-10365
Schmidt-Pokrzywniak A, Kalbitz S, Kuss O, Jöckel KH, Bornfeld N, Stang A. Assessment of the effect of iris colour and having children on 5-year risk of death after diagnosis of uveal melanoma: a follow-up study. BMC Ophthalmol. 2014;14(1):42. https://doi.org/10.1186/1471-2415-14-42
Egan KM, Quinn JL, Gragoudas ES. Childbearing history associated with improved survival in choroidal melanoma. Arch Ophthalmol. 1999;117(7):939-942. https://doi.org/10.1001/archopht.117.7.939
Janerich DT. The fetal antigen hypothesis for breast cancer, revisited. Med Hypotheses. 1994;43(2):105-110. https://doi.org/10.1016/0306-9877(94)90059-0
Beard HH. Correlation of the unitarian or trophoblastic thesis with the biological test of malignancy. Fed Proc. 1948;7(1 Pt 1):145.
Krebs ET, Jr. Carcinogenesis; in the light of the trophoblastic or unitarian thesis of cancer. Int Rec Med Gen Pract Clin. 1951;164(3):141-169; contd.
Enninga EA, Holtan SG, Creedon DJ, Dronca RS, Nevala WK, Ognjanovic S, Markovic SN. Immunomodulatory effects of sex hormones: requirements for pregnancy and relevance in melanoma. Mayo Clin Proc. 2014; 89(4):520-535. https://doi.org/10.1016/j.mayocp.2014.01.006
Siegel R, Ainslie WH. Malignant ocular melanoma during pregnancy. JAMA. 1963;185:542-543. https://doi.org/10.1001/jama.1963.03060060140028
Seddon JM, MacLaughlin DT, Albert DM, Gragoudas ES, Ference M 3rd. Uveal melanomas presenting during pregnancy and the investigation of oestrogen receptors in melanomas. Br J Ophthalmol. 1982;66(11):695-704. https://doi.org/10.1136/bjo.66.11.695
Shields CL, Shields JA, Eagle RC Jr, De Potter P, Menduke H. Uveal melanoma and pregnancy. A report of 16 cases. Ophthalmology. 1991;98(11): 1667-1673. https://doi.org/10.1016/s0161-6420(91)32060-8
Lee CS, Yang WI, Shin KJ, Lee SC. Rapid growth of choroidal melanoma during pregnancy. Acta Ophthalmol. 2011;89(3):290-291. https://doi.org/10.1111/j.1755-3768.2009.01803.x
Frenkel M, Klein HZ. Malignant melanoma of the choroid in pregnancy. Am J Ophthalmol. 1966;62(5):910-913.
Marsh RD, Chu NM. Placental metastasis from primary ocular melanoma: a case report. Am J Obstet Gynecol. 1996;174(5):1654-1655. https://doi.org/10.1016/s0002-9378(96)70626-9
Romanowska-Dixon B. Melanoma of choroid during pregnancy: case report. Klin Oczna. 2002;104(5-6):395-397.
Charif Chefchaouni M, Hajji Z, Berbich O, Bernoussi A, Benchrifa F, Sefiani S, et al. Melanoma of the iris and pregnancy. J Fr Ophtalmol. 2003; 26(3):277-280. https://doi.org/10.1016/j.sagf.2014.10.001
Skarmoutsos F, Durnian JM, Damato BE. Delayed treatment of choroidal melanoma due to pregnancy. Eur J Ophthalmol. 2006;16(6):876-878. https://doi.org/10.1177/112067210601600618
Grgić Z, Oros A, Rašić D, Popović L, Popović M. Ocular malignant melanoma in pregnancy: is a happy ending possible? Arch Oncol. 2009;17:83-85. https://doi.org/10.2298/AOO0904083G
Kheir WJ, Materin MA. Choroidal melanoma during pregnancy: a case report and review of the literature. Retin Cases Brief Rep. 2021;15(5):556-563. https://doi.org/10.1097/ICB.0000000000000851
Lemaitre S, Levy-Gabriel C, Desjardins L, Plancher C, Asselain B, Vincent-Salomon A, et al. Choroidal melanoma and pregnancy. Acta Ophthalmol. 2016;94(7):652-660. https://doi.org/10.1111/aos.12984
Semenova E, Finger PT, Kalach N, Choi W. Palladium-103 brachytherapy for choroidal melanoma in a pregnant woman. Ophthalmic Surg Lasers Imaging Retina. 2018;49(5):364-368. https://doi.org/10.3928/23258160-20180501-11
Qiu M, Shields CL. Relationship between female reproductive factors and choroidal nevus in US women: analysis of data from the 2005—2008 National Health and Nutrition Examination Survey. JAMA Ophthalmol. 2015; 133(11):1287-1294. https://doi.org/10.1001/jamaophthalmol.2015.3178
Hartge P, Tucker MA, Shields JA, Augsburger J, Hoover RN, Fraumeni JF Jr. Case-control study of female hormones and eye melanoma. Cancer Res. 1989;49(16):4622-4625.
Behrens T, Kaerlev L, Cree I, Lutz JM, Afonso N, Eriksson M, et al. Hormonal exposures and the risk of uveal melanoma. Cancer Causes Control. 2010;21(10):1625-1634. https://doi.org/10.1007/s10552-010-9591-9
Zinkhan M, Stang A, Jöckel KH, Marr A, Bornfeld N, Schmidt-Pokrzywniak A. Having children, social characteristics, smoking and the risk of uveal melanoma: a case-control study. Ophthalm Epidemiol. 2013;20(6):360-368. https://doi.org/10.3109/09286586.2013.844842
Holly EA, Aston DA, Ahn DK, Kristiansen JJ, Char DH. Uveal melanoma, hormonal and reproductive factors in women. Cancer Res. 1991;51(5):1370-1372.
Egan KM, Walsh SM, Seddon JM, Gragoudas ES. An evaluation of the influence of reproductive factors on the risk of metastases from uveal melanoma. Ophthalmology. 1993;100(8):1160-1166; discussion 1166. https://doi.org/10.1016/s0161-6420(93)31512-5
Stein RA, McDonnell DP. Estrogen-related receptor alpha as a therapeutic target in cancer. Endocr Relat Cancer. 2006;13(suppl 1):25-32.20. https://doi.org/10.1677/erc.1.01292
Ghanbari F, Hebert-Losier A, Barry J, Poirier D, Giguere V, Mader S, et al. Isolation and functional characterization of a novel endogenous inverse agonist of estrogen related receptors (ERRs) from human pregnancy urine. J Steroid Biochem Mol Biol. 2019;191:105352. https://doi.org/10.1016/j.jsbmb.2019.04.001
Bombail V, Gibson DA, Collins F, MacPherson S, Critchley HO, Saunders PT. A role for the orphan nuclear receptor estrogen-related receptor alpha in endometrial stromal cell decidualization and expression of genes implicated in energy metabolism. J Clin Endocrinol Metab. 2010;95(10):224-228. https://doi.org/10.1210/jc.2010-0154
Marsh RD, Chu NM. Placental metastasis from primary ocular melanoma: a case report. Am J Obstet Gynecol. 1996;174(5):1654-1655. https://doi.org/10.1016/s0002-9378(96)70626-9
Foss AJ, Alexander RA, Guille MJ, Hungerford JL, McCartney AC, Lightman S. Estrogen and progesterone receptor analysis in ocular melanomas. Ophthalmology. 1995;102(3):431-435. https://doi.org/10.1016/s0161-6420(95)31004-4.
Makitie T, Tarkkanen A, Kivela T. Comparative immunohistochemical oestrogen receptor analysis in primary and metastatic uveal melanoma. Graefes Arch Clin Exp Ophthalmol. 1998;236:415-419. https://doi.org/10.1007/s004170050099
Sahakyan SV, Zhiltsova MG, Valsky VV. Evaluation of expression of estrogen and progesterone receptors in tumor cells of uveal melanoma. Rossijskij oftal’mologicheskij zhurnal. 2018;11(1):17-23. (In Russ). https://doi.org/10.21516/2072-0076-2018-11-1-17-23
Grostern RJ, Slusker Shternfeld I, Bacus SS, Gilchrist K, Zimbric ML, Albert DM. Absence of type I estrogen receptors in choroidal melanoma: analysis of Collaborative Ocular Melanoma Study (COMS) eyes. Am J Ophthalmol. 2001;131(6):788-791. https://doi.org/10.1016/s0002-9394(00)00959-4
Schoenfield L, Plesec T, Downs-Kelly E, Aronow MB, Carver P, Tubbs R, et al. Gender differences and estrogen and progesterone receptor expression in uveal melanoma. Invest Ophthalmol Vis Sci. 2013;54:ARVO E-Abstract 4224. https://doi.org/10.1167/iovs.12-10365
Schoenfield LJS, Kline D, Aronow ME, Singh AD, Craven C, Abdel-Rahman M, et al. Estrogen receptor is expressed in uveal melanoma: a potential target for therapy. Ocular Oncol Pathol. 2021;7:303-310. https://doi.org/10.1159/000512174
Robertson AG, Shih J, Yau C, Gibb EA, Oba J, Mungall KL, et al. Integrative analysis identifies four molecular and clinical subsets in uveal melanoma. Cancer Cell. 2017;32(2):204-e215. https://doi.org/10.1016/j.ccell.2017.07.003
Huffman KE, Carstens R, Martinez ED. A subset of nuclear receptors are uniquely expressed in uveal melanoma cells. Front Endocrinol. 2015;6:93. https://doi.org/10.3389/fendo.2015.00093
Chou CS, Beristain AG, MacCalman CD, Leung PC. Cellular localization of gonadotropin-releasing hormone (GnRH) I and GnRH II in first-trimester human placenta and decidua. J Clin Endocrinol Metab. 2004;89(3):1459-1466. https://doi.org/10.1210/jc.2003-031636
Gohar J, Mazor M, Leiberman JR. GnRH in pregnancy. Arch Gynecol Obstet. 1996;259(1):1-6. https://doi.org/10.1007/BF02505301
Treszl A, Steiber Z, Schally AV, Block NL, Dezso B, Olah G, et al. Substantial expression of luteinizing hormone-releasing hormone (LHRH) receptor type I in human uveal melanoma. Oncotarget. 2013;4(10):1721-1728. https://doi.org/10.18632/oncotarget.1379
Fodor K, Dobos N, Schally A, Steiber Z, Olah G, Sipos E, et al. The targeted LHRH analog AEZS-108 alters expression of genes related to angiogenesis and development of metastasis in uveal melanoma. Oncotarget. 2020; 11(2):175-187. https://doi.org/10.18632/oncotarget.27431
Hu C, Fang D, Xu H, Wang Q, Xia H. The androgen receptor expression and association with patient’s survival in different cancers. Genomics. 2020; 112(2):1926-1940. https://doi.org/10.1016/j.ygeno.2019.11.005
López MN, Pereda C, Ramirez M, Mendoza-Naranjo A, Serrano A, Ferreira A, et al. Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for diagnosis and immunotherapy. Invest Ophthalmol Vis Sci. 2007;48:1219-1227. https://doi.org/10.1167/iovs.06-0090
Metzelaar-Blok JA, ter Huurne JA, Hurks HM, Keunen JE, Jager MJ, Gruis NA. Characterization of melanocortin-1 receptor gene variants in uveal melanoma patients. Invest Ophthalmol Vis Sci. 2001;42(9):1951-1954.
Goodall T, Buffey JA, Rennie IG, Benson M, Parsons MA, Faulkner MK, et al. Effect of melanocyte stimulating hormone on human cultured choroidal melanocytes, uveal melanoma cells, and retinal epithelial cells. Invest Ophthalmol Vis Sci. 1994;35(3):826-837.
Cantón I, Eves PC, Szabo M, Vidal-Vanaclocha F, Sisley K, Rennie IG, et al. Tumor necrosis factor α increases and α-melanocyte-stimulating hormone reduces uveal melanoma invasion through fibronectin. J Invest Dermatol. 2003;121:557-563. https://doi.org/10.1046/j.1523-1747.2003.12417.x

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