The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
Phones:
+7 (495) 482-4118
+7 (495) 482-4329
  • Toll-free number for subscriptions:
    +8 800 250-18-12
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Kurysheva N.I.

Medical and Biological University of Innovation and Continuing Education of the Federal Medical Biophysical Center named after A.I. Burnazyan;
Consultative and Diagnostic Department of the Ophthalmological Center of the Federal Medical Biophysical Center named after A.I. Burnazyan

Sharova G.A.

Eye Clinic of Doctor Belikova LLC

Comparative study of retinal microcirculation in primary angle closure disease and early primary open-angle glaucoma

Authors:

Kurysheva N.I., Sharova G.A.

More about the authors

Journal: Russian Annals of Ophthalmology. 2022;138(1): 44‑51

DOI: 10.17116/oftalma202213801144

Read: 3562 times

Contact the author
Table of contents

COMPARATIVE STUDY OF RETINAL MICROCIRCULATION IN PRIMARY ANGLE CLOSURE DISEASE AND EARLY PRIMARY OPEN-ANGLE GLAUCOMA
COMPARATIVE STUDY OF RETINAL MICROCIRCULATION IN PRIMARY ANGLE CLOSURE DISEASE AND EARLY PRIMARY OPEN-ANGLE GLAUCOMA

To cite this article:

Kurysheva NI, Sharova GA. Comparative study of retinal microcirculation in primary angle closure disease and early primary open-angle glaucoma. Russian Annals of Ophthalmology. 2022;138(1):44‑51. (In Russ., In Engl.)
https://doi.org/10.17116/oftalma202213801144

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Abstract:

PURPOSE

To compare microcirculatory changes in patients with early stages of primary angle closure disease (PACD) and primary open-angle glaucoma (POAG).

MATERIAL AND METHODS

The study retrospectively analyzed the clinical data of 60 eyes with PACD, 30 with initial POAG, and 30 eyes without any ophthalmic pathologies. Vessel density (VD) in the optic nerve head and peripapillary retina (wiVD Disc), as well as in the inner layers of fovea and parafovea (wiVD Macula) and their different sectors were determined in all patients by optical coherence tomography angiography (OCTA). The correlation of VD with axial length (AL), anterior chamber depth (ACD), lens thickness (TL), and corneal-compensated intraocular pressure (IOPcc) was assessed.

RESULTS

The wiVD Disc in PACD (42.47±4.23%) was lower than in POAG eyes (47.46±2.10%), p<0.001, but the difference for wiVD Macula was not significant: 41.71±4.55% and 39.29±2.46%, respectively (p=0.47). In both PACD and POAG, all OCTA parameters were lower than in normal eyes: p=0.000 for both wiVD Disc and wiVD Macula. WiVD Disc correlated with ACD both in PACD (r=0.724, p=0.012) and in POAG (r= 0.685, p=0.012), but a correlation with IOPcc was found only in PACD (r= –0.670, p=0.033). The largest number of inverse correlations was found between TL and VD both for wiVD Disc (r= –0.714, p=0.006) and the parameters of macular area (in para- and perifovea).

CONCLUSION

OCTA parameters differ significantly from the norm even in the early stages of both PACD and POAG. In PACD, there was a significant decrease in microcirculation in the peripapillary retina compared to POAG, which had an inverse correlation with IOPcc; there was also an inverse correlation of OCTA parameters in the optic nerve head and macula with lens thickness.

Keywords:

primary angle closure
primary angle closure glaucoma
primary open-angle glaucoma
optical coherence tomography angiography
lens thickness
intraocular pressure

Authors:

Kurysheva N.I.

Medical and Biological University of Innovation and Continuing Education of the Federal Medical Biophysical Center named after A.I. Burnazyan;
Consultative and Diagnostic Department of the Ophthalmological Center of the Federal Medical Biophysical Center named after A.I. Burnazyan

Sharova G.A.

Eye Clinic of Doctor Belikova LLC

Received:

24.10.2021

Accepted:

24.11.2021

Close metadata

References:

  1. Quek DT, Koh VT, Tan GS. Blindness and long-term progression of visual field defects in Chinese patients with primary angle-closure glaucoma. Am J Ophthalmol. 2011;152(3):463-469.  https://doi.org/10.1016/j.ajo.2011.02.023
  2. Foster PJ, Buhrmann R, Quigley HA, Johnson GJ. The definition and classification of glaucoma in prevalence surveys. Br J Ophthalmol. 2002;86(2): 238-242.  https://doi.org/10.1136/bjo.86.2.238
  3. Zhang X, Dastiridou A, Francis BA, Tan O, Varma R, Greenfield DS, Schuman JS, Huang D; Advanced Imaging for Glaucoma Study Group. Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field. Am J Ophthalmol. 2017;184:63-74.  https://doi.org/10.1016/j.ajo.2017.09.020
  4. Gyatsho J, Kaushik S, Gupta A, Pandav SS, Ram J. Retinal nerve fiber layer thickness in normal, ocular hypertensive, and glaucomatous Indian eyes: an optical coherence tomography study. J Glaucoma. 2008;17(2):122-127.  https://doi.org/10.1097/IJG.0b013e31814b9817
  5. Lisboa R, Paranhos A Jr, Weinreb RN, Zangwill LM, Leite MT, Medeiros FA. Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric glaucoma. Invest Ophthalmol Vis Sci. 2013;54(5): 3417-3425. https://doi.org/10.1167/iovs.13-11676
  6. Liu L, Jia Y, Takusagawa HL, et al. Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma. JAMA Ophthalmol. 2015; 133(9):1045-1052. https://doi.org/10.1001/jamaophthalmol.2015.2225
  7. Wang X, Jiang C, Ko T, et al. Correlation between optic disc perfusion and glaucomatous severity in patients with open-angle glaucoma: an optical coherence tomography angiography study. Graefes Arch Clin Exp Ophthalmol. 2015;253(9):1557-1564. https://doi.org/10.1007/s00417-015-3095-y
  8. Yarmohammadi A, Zangwill LM, Diniz-Filho A, et al. Optical Coherence Tomography Angiography Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes. Invest Ophthalmol Vis Sci. 2016;57(9):OCT451-OCT459. https://doi.org/10.1167/iovs.15-18944
  9. Zhang S, Wu C, Liu L, et al. Optical Coherence Tomography Angiography of the Peripapillary Retina in Primary Angle-Closure Glaucoma. Am J Ophthalmol. 2017;182:194-200.  https://doi.org/10.1016/j.ajo.2017.07.024
  10. Wang X, Jiang C, Kong X, Yu X, Sun X. Peripapillary retinal vessel density in eyes with acute primary angle closure: an optical coherence tomography angiography study. Graefes Arch Clin Exp Ophthalmol. 2017;255(5):1013-1018. https://doi.org/10.1007/s00417-017-3593-1
  11. Moghimi S, SafiZadeh M, Fard MA, et al. Changes in Optic Nerve Head Vessel Density After Acute Primary Angle Closure Episode. Invest Ophthalmol Vis Sci. 2019;60(2):552-558.  https://doi.org/10.1167/iovs.18-25915
  12. Hou TY, Kuang TM, Ko YC, Chang YF, Liu CJ, Chen MJ. Optic Disc and Macular Vessel Density Measured by Optical Coherence Tomography Angiography in Open-Angle and Angle-Closure Glaucoma. Sci Rep. 2020; 10(1):5608. https://doi.org/10.1038/s41598-020-62633-4
  13. Zhang X. Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field. Am J Ophthalmol. 2017;184:63-74.  https://doi.org/10.1016/j.ajo.2017.09.020
  14. Kurysheva NI, Maslova EV, Zolnikova IV, et al. A comparative study of structural, functional and circulatory parameters in glaucoma diagnostics. PloS One. 2018 Aug 23;13(8):e0201599. https://doi.org/10.1371/journal.pone.0201599
  15. Rao HL, Pradhan ZS, Weinreb RN, et al. Vessel Density and Structural Measurements of Optical Coherence Tomography in Primary Angle Closure and Primary Angle Closure Glaucoma. Am J Ophthalmol. 2017;177:106-115.  https://doi.org/10.1016/j.ajo.2017.02.020
  16. Yu DY, Cringle SJ. Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease. Prog Retin Eye Res. 2001;20:175-208.  https://doi.org/10.1016/S1350-9462(00)00027-6
  17. Kurysheva NI, Sharova GA. The Role of Optical Coherence Tomography in the Diagnosis of Angle Closed Diseases of the Anterior Chamber. Part 1: Visualization of the Anterior Segment of the Eye. Ophthalmology in Russia = Oftal’mologiya. 2021;18(2):208-215 (In Russ.). https://doi.org/10.18008/1816-5095-2021-2-208-215
  18. Kurysheva NI, Sharova GA. The Role of Optical Coherence Tomography in the Diagnosis of Angle Closed Diseases of the Anterior Chamber. Part 1: Visualization of the Posterior Segment of the Eye. Ophthalmology in Russia = Oftal’mologiya. 2021;8(3):381-388 (In Russ.). https://doi.org/10.18008/1816-5095-2021-3-381-388
  19. Guo ZZ, Chang K, Wei X. Intraocular pressure fluctuation and the risk of glaucomatous damage deterioration: a metaanalysis. Int J Ophthalmol. 2019; 12(1):123-128.  https://doi.org/10.18240/ijo.2019.01.19
  20. Zhu L, Zong Y, Yu J, et al. Reduced Retinal Vessel Density in Primary Angle Closure Glaucoma: A Quantitative Study Using Optical Coherence Tomography Angiography. J Glaucoma. 2018;27(4):322-327.  https://doi.org/10.1097/IJG.0000000000000900
  21. Jo YH, Sung KR, Yun SC. The Relationship Between Peripapillary Vascular Density and Visual Field Sensitivity in Primary Open-Angle and Angle-Closure Glaucoma. Invest Ophthalmol Vis Sci. 2018;59(15):5862-5867. https://doi.org/10.1167/iovs.18-25423
  22. Rao HL, Sreenivasaiah S, Riyazuddin M, et al. Choroidal Microvascular Dropout in Primary Angle Closure Glaucoma. Am J Ophthalmol. 2019; 199:184-192.  https://doi.org/10.1016/j.ajo.2018.11.021
  23. Azuara-Blanco A, Burr J, Ramsay C, et al. Effectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (EAGLE): a randomised controlled trial. Lancet. 2016;388(10052):1389-1397. https://doi.org/10.1016/S0140-6736(16)30956-4
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.